PMC:7736111 / 103535-104306 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2413 108-116 Species denotes patients Tax:9606
2414 343-353 Species denotes SARS-CoV-2 Tax:2697049
2415 603-613 Species denotes SARS-CoV-2 Tax:2697049
2416 243-250 Chemical denotes BD-368-
2417 99-107 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T611 0-117 Sentence denotes In an elegant recent study, Cao et al. (2020) performed sc-RNA-seq of B cells from 60 convalescent COVID-19 patients.
T612 118-242 Sentence denotes The study led to the identification of 14 neutralizing antibodies, among which one (BD-368-2) showed the most potent effect.
T613 243-373 Sentence denotes BD-368-2 was further explored for its efficacy in animal models and showed therapeutic potential in SARS-CoV-2 transgenic animals.
T614 374-614 Sentence denotes Further, the study suggested the use of two different monoclonal antibodies targeting different epitopes as a more viable therapeutic intervention than a single antibody, which is impressive considering the emerging mutations in SARS-CoV-2.
T615 615-771 Sentence denotes Thus, more research in this direction is needed to find antibodies with potent neutralization property for targeted therapy to alleviate the disease burden.