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PMC:7736111 / 10142-13075 JSONTXT

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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T8 58-66 Phenotype denotes melanoma http://purl.obolibrary.org/obo/HP_0002861

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
238 51-56 Gene denotes RIG-I Gene:23586
239 58-100 Gene denotes melanoma differentiation-associated gene 5 Gene:64135
240 102-106 Gene denotes MDA5 Gene:64135
241 178-183 Gene denotes DHX58 Gene:79132
242 199-203 Gene denotes LGP2 Gene:79132
243 254-259 Gene denotes RIG-I Gene:23586
244 303-307 Gene denotes MDA5 Gene:64135
245 421-426 Gene denotes RIG-I Gene:23586
246 431-435 Gene denotes MDA5 Gene:64135
247 523-528 Gene denotes RIG-I Gene:23586
248 584-590 Gene denotes TRIM25 Gene:7706
249 655-659 Gene denotes MDA5 Gene:64135
250 729-756 Gene denotes poly (rC) binding protein 2 Gene:5094
251 758-763 Gene denotes PCBP2 Gene:5094
252 786-790 Gene denotes AIP4 Gene:83737
253 791-795 Gene denotes ITCH Gene:83737
254 797-829 Gene denotes Atrophin 1 Interacting Protein 4 Gene:83737
255 843-847 Gene denotes ITCH Gene:83737
256 869-873 Gene denotes LGP2 Gene:79132
257 924-929 Gene denotes RIG-1 Gene:5920
258 934-938 Gene denotes MDA5 Gene:64135
259 971-976 Gene denotes RIG-I Gene:23586
260 981-985 Gene denotes MDA5 Gene:64135
261 1051-1092 Gene denotes mitochondrial antiviral signaling protein Gene:57506
262 1094-1098 Gene denotes MAVS Gene:57506
263 1153-1157 Gene denotes IRF3 Gene:3661
264 1158-1162 Gene denotes IRF7 Gene:3665
265 1207-1213 Gene denotes IRF3/7 Gene:3661
266 1277-1280 Gene denotes IFN Gene:3439
267 1401-1405 Gene denotes MAVS Gene:57506
268 1439-1442 Gene denotes IFN Gene:3439
269 1453-1457 Gene denotes IRF3 Gene:3661
270 1462-1466 Gene denotes IRF7 Gene:3665
271 1572-1577 Gene denotes NF κB Gene:4790
272 1749-1754 Gene denotes NF κB Gene:4790
273 1803-1809 Gene denotes IRF3/7 Gene:3661
274 1813-1818 Gene denotes NF κB Gene:4790
275 2148-2152 Gene denotes TLR3 Gene:142980
276 2157-2161 Gene denotes TLR4 Gene:21898
277 2357-2362 Gene denotes MYD88 Gene:17874
278 2552-2556 Gene denotes TLR7 Gene:51284
279 2558-2562 Gene denotes TLR8 Gene:51311
280 2568-2572 Gene denotes TLR9 Gene:54106
281 2599-2603 Gene denotes TLR4 Gene:7099
282 2021-2025 Species denotes mice Tax:10090
283 2171-2175 Species denotes mice Tax:10090
284 2288-2292 Species denotes Mice Tax:10090
285 2077-2086 Disease denotes infection MESH:D007239
286 2128-2146 Disease denotes SARS-CoV infection MESH:C000657245
287 2225-2236 Disease denotes lung damage MESH:D008171
288 2250-2259 Disease denotes mortality MESH:D003643
289 2459-2468 Disease denotes mortality MESH:D003643
290 2679-2701 Disease denotes attenuated lung damage MESH:C538265
291 2738-2755 Disease denotes SARS-CoV infected MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T54 0-253 Sentence denotes RLRs are a complex of sensor proteins that include RIG-I, melanoma differentiation-associated gene 5 (MDA5), and the more recently discovered probable ATP-dependent RNA helicase DHX58 (also known as LGP2) (Jiang et al., 2011; Leiva-Juárez et al., 2018).
T55 254-359 Sentence denotes RIG-I binds to 5’-PPP RNA and short dsRNA, while MDA5 binds to longer RNA fragments (Huang et al., 2014).
T56 360-509 Sentence denotes Binding of pathogenic RNAs induces conformational changes in RIG-I and MDA5, and after that post-translational modifications activate these proteins.
T57 510-868 Sentence denotes Importantly, RIG-I is activated by E3 ligase tripartite motif protein 25 (TRIM25) via polyubiquitination at K172 residue (Sanchez et al., 2016); MDA5 is proteolytically inactivated by the polyubiquitination mediated by poly (rC) binding protein 2 (PCBP2) with assistance from AIP4/ITCH (Atrophin 1 Interacting Protein 4; also called ITCH) (You et al., 2009).
T58 869-960 Sentence denotes LGP2 acts as a facilitator to enhance viral sensing by RIG-1 and MDA5 (Satoh et al., 2010).
T59 961-1196 Sentence denotes Activated RIG-I and MDA5 then mount the downstream signaling cascade via centrally placed mitochondrial antiviral signaling protein (MAVS) and eventually lead to the coordinated activation of IRF3/IRF7 transcription factors (Figure 2).
T60 1197-1377 Sentence denotes Activated IRF3/7 translocates to the nucleus and induces expression of IFNs via IFN-stimulated response element (ISRE) reviewed by West et al. (2011) and Rehwinkel and Gack (2020).
T61 1378-1599 Sentence denotes Thus, centrally placed MAVS activation induces expression of IFN genes via IRF3 and IRF7 pathways and recruitment of other innate immune cells, majorly by proinflammatory molecules secreted via NF κB signaling (Figure 2).
T62 1600-1783 Sentence denotes Similarly, activation of endogenous TLR pathway induces expression of IFN type I, type III, and more specifically, proinflammatory molecules via the NF κB pathway (Gong et al., 2020).
T63 1784-2001 Sentence denotes Blocking of either IRF3/7 or NF κB pathway has a detrimental effect on host cells that invariably allows propagation of the virus (Lazear et al., 2013; Schmitz et al., 2014; Totura et al., 2015; Chiang and Liu, 2019).
T64 2002-2147 Sentence denotes In animal studies, mice that are deficient in TLR signaling exhibit robust infection and severe pathological condition during SARS-CoV infection.
T65 2148-2287 Sentence denotes TLR3 and TLR4 knockout mice exhibited increased viral titers associated with lung damage and a higher mortality rate (Totura et al., 2015).
T66 2288-2497 Sentence denotes Mice with a knockout of myeloid differentiation primary response 88 (MYD88), which acts downstream of TLR signaling had increased damage to the lung parenchyma with a 90% mortality rate (Sheahan et al., 2008).
T67 2498-2784 Sentence denotes Conversely, activation of endogenous TLR signaling by TLR7, TLR8, and TLR9 or cell surface-expressed TLR4 signaling was associated with a significant decrease in viral propagation, attenuated lung damage, and increased the survival rate in SARS-CoV infected animals (Zhao et al., 2012).
T68 2785-2933 Sentence denotes These findings thus point to an integral role of these molecular sensors in mounting early protective antiviral response and aiding viral clearance.