PMC:7723248 / 39226-40329 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7723248","sourcedb":"PMC","sourceid":"7723248","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7723248","text":"To conclude, we demonstrated that both the chemical composition of droplets and RH strongly affect the viability of non-enveloped and enveloped viruses. The effects of sodium chloride and SDS varied by RH level and virus type. pH did not affect the viability of MS2 but effectively inactivated Φ6 in solutions at pHs of 4 and 10. BSA generally preserved the viability of MS2 and Φ6 in droplets. We also found that the viability of viruses in droplets of certain compositions was RH-dependent at most conditions. Our results reveal that two factors contribute to the inactivation of viruses in droplets: (1) droplet evaporation kinetics, which are controlled by RH; and (2) inactivation or protective effects induced by chemicals. Additionally, the physical behavior of viruses, such as forming aggregates and partitioning to the air-liquid interface, resulting from changes in droplets’ characteristics may also affect inactivation. Results from our study are meaningful in predicting the persistence of viruses in droplets of various compositions in the environment and infectious disease transmission.","tracks":[]}