PMC:7723248 / 29008-30408 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7723248","sourcedb":"PMC","sourceid":"7723248","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7723248","text":"The relative viability of MS2 and Φ6 was elevated in droplets containing BSA at RHs of 50% and 80%. Previous studies have found that the decay of viruses was greatly reduced in both aerosols and droplets supplemented with human respiratory fluid or fetal calf serum [17, 18]; protein may provide a protective effect. For example, influenza virus retained its viability in aerosols across a wide range of RHs after 1 h when the aerosolization media was supplemented with extracellular matrix from human bronchial epithelial cells. Here, we suspended viruses in media containing BSA and observed a similar protective effect. The detailed mechanism by which proteins protect viruses from decay remains unknown. Researchers have proposed that the inactivation of viruses in aerosols and droplets mainly happens at the air-water interface [61, 62]. The presence of proteins in droplets may reduce the solution surface tension, which inhibits viruses from reaching the air-water interface [63, 64]. Another possible mechanism is that potentially damaging compounds may first act on free proteins in droplets instead of those on the surfaces of viruses. Quantitative information on residual “free protein” in droplets over the course of exposure would be useful to test this hypothesis. It is also possible that proteins in solution may interact with those on the surface of viruses and help stabilize them.","tracks":[]}