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PMC:7717252 / 104-1234 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
13 147-153 Species denotes people Tax:9606
14 168-178 Species denotes SARS-CoV-2 Tax:2697049
15 920-928 Species denotes patients Tax:9606
16 592-593 Chemical denotes N MESH:D009584
17 812-813 Chemical denotes N MESH:D009584
18 881-900 Chemical denotes N-acetylglucosamine MESH:D000117
19 902-908 Chemical denotes GlcNAc MESH:D000117
20 90-98 Disease denotes COVID-19 MESH:C000657245
21 154-162 Disease denotes infected MESH:D007239
22 418-426 Disease denotes COVID-19 MESH:C000657245
23 635-643 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T4 0-109 Sentence denotes A large variation in the severity of disease symptoms is one of the key open questions in COVID-19 pandemics.
T5 110-341 Sentence denotes The fact that only a small subset of people infected with SARS-CoV-2 develop severe disease suggests that there have to be some predisposing factors, but biomarkers that reliably predict disease severity have not been found so far.
T6 342-644 Sentence denotes Since overactivation of the immune system is implicated in a severe form of COVID-19 and the IgG glycosylation is known to be involved in the regulation of different immune processes, we evaluated the association of inter-individual variation in IgG N-glycome composition with the severity of COVID-19.
T7 645-822 Sentence denotes The analysis of 166 severe and 167 mild cases from hospitals in Spain, Italy and Portugal revealed statistically significant differences in the composition of the IgG N-glycome.
T8 823-952 Sentence denotes The most notable difference was the decrease in bisecting N-acetylglucosamine (GlcNAc) in severe patients from all three cohorts.
T9 953-1130 Sentence denotes IgG galactosylation was also lower in severe cases in all cohorts, but the difference in galactosylation was not statistically significant after correction for multiple testing.