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PMC:7717252 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 76-84 Disease denotes COVID-19 MESH:C000657245
13 251-257 Species denotes people Tax:9606
14 272-282 Species denotes SARS-CoV-2 Tax:2697049
15 1024-1032 Species denotes patients Tax:9606
16 696-697 Chemical denotes N MESH:D009584
17 916-917 Chemical denotes N MESH:D009584
18 985-1004 Chemical denotes N-acetylglucosamine MESH:D000117
19 1006-1012 Chemical denotes GlcNAc MESH:D000117
20 194-202 Disease denotes COVID-19 MESH:C000657245
21 258-266 Disease denotes infected MESH:D007239
22 522-530 Disease denotes COVID-19 MESH:C000657245
23 739-747 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-84 Sentence denotes Composition of the immunoglobulin G glycome associates with the severity of COVID-19
T2 86-94 Sentence denotes Abstract
T3 95-103 Sentence denotes Abstract
T4 104-213 Sentence denotes A large variation in the severity of disease symptoms is one of the key open questions in COVID-19 pandemics.
T5 214-445 Sentence denotes The fact that only a small subset of people infected with SARS-CoV-2 develop severe disease suggests that there have to be some predisposing factors, but biomarkers that reliably predict disease severity have not been found so far.
T6 446-748 Sentence denotes Since overactivation of the immune system is implicated in a severe form of COVID-19 and the IgG glycosylation is known to be involved in the regulation of different immune processes, we evaluated the association of inter-individual variation in IgG N-glycome composition with the severity of COVID-19.
T7 749-926 Sentence denotes The analysis of 166 severe and 167 mild cases from hospitals in Spain, Italy and Portugal revealed statistically significant differences in the composition of the IgG N-glycome.
T8 927-1056 Sentence denotes The most notable difference was the decrease in bisecting N-acetylglucosamine (GlcNAc) in severe patients from all three cohorts.
T9 1057-1234 Sentence denotes IgG galactosylation was also lower in severe cases in all cohorts, but the difference in galactosylation was not statistically significant after correction for multiple testing.