PMC:7712180 / 84291-85453 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7712180","sourcedb":"PMC","sourceid":"7712180","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7712180","text":"Historical data indicated that CoVs, which infect humans by using a specific host protein as a primary receptor, including HCoV-229E (APN), HCoV-NL63 (ACE2), SARS-CoV (ACE2), SARS-CoV-2 (ACE2) and MERS-CoV (DDP4), originated from bats, whereas HCoV-OC43 and HCoV-HKU1, which use Neu5,9Ac2, originated from rodents [255]. In contrast, IAVs infecting humans using sialyl glycans are thought to have originated from wild birds. The finding that some H16 HAs isolated from wild birds contain Y98F, being different from HAs of other Sia-binding IAVs but the same as bat non-Sia-binding HAs of H17 and H18 IAVs, and the finding that there are bat α2,3Sia-binding IAV isolates that are phylogenetically different from other identified IAVs with HA closest to mallard H9 viruses indicate the possibility of cross wild bird-to-bat and/or bat-to-wild bird transmission of IAVs [64]. Studies on evolutional changes of wild bird IAVs and bat IAVs may lead to clarification of the host origins of IAVs. An understanding of viral adaptation in the wild animals to recognize distinct receptors may lead to the establishment of strategies for efficient control of CoVs and 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