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PMC:7712180 / 80382-82273 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2838 723-727 Gene denotes α2,3 Gene:28923
2839 733-737 Gene denotes α2,6 Gene:28906
2840 772-776 Gene denotes α2,3 Gene:28923
2841 819-823 Gene denotes α2,3 Gene:28923
2842 915-928 Gene denotes neuraminidase Gene:4758
2843 1448-1461 Gene denotes neuraminidase Gene:4758
2844 1644-1647 Gene denotes pdb Gene:5131
2845 1315-1317 Gene denotes α2 Gene:170589
2846 1271-1273 Gene denotes α2 Gene:170589
2847 172-175 Gene denotes NTD Gene:80199
2848 32-37 Species denotes human Tax:9606
2849 61-69 Species denotes MERS-CoV Tax:1335626
2850 128-136 Species denotes MERS-CoV Tax:1335626
2851 702-710 Species denotes MERS-CoV Tax:1335626
2852 891-896 Species denotes human Tax:9606
2853 952-960 Species denotes MERS-CoV Tax:1335626
2854 1044-1052 Species denotes MERS-CoV Tax:1335626
2855 1154-1163 Species denotes dromedary Tax:9838
2856 1164-1169 Species denotes camel Tax:9838
2857 1194-1199 Species denotes human Tax:9606
2858 1344-1355 Species denotes pipistrelle Tax:59474
2859 1518-1526 Species denotes MERS-CoV Tax:1335626
2860 1607-1615 Species denotes MERS-CoV Tax:1335626
2861 1634-1638 Gene denotes α2,3 Gene:28923
2862 1639-1642 Gene denotes SLN Gene:6588
2863 208-214 Chemical denotes glycan MESH:D011134
2864 338-344 Chemical denotes glycan MESH:D011134
2865 425-431 Chemical denotes Neu5Ac
2866 472-478 Chemical denotes Neu5Ac
2867 494-500 Chemical denotes Neu5Gc
2868 512-519 Chemical denotes glycans MESH:D011134
2869 1422-1429 Chemical denotes glycans MESH:D011134
2870 1850-1856 Chemical denotes Neu5Ac
2871 939-948 Disease denotes infection MESH:D007239
2872 999-1017 Disease denotes MERS-CoV infection MESH:D018352
2873 1117-1126 Disease denotes infection MESH:D007239
2874 1540-1548 Disease denotes infected MESH:D007239
2875 884-890 CellLine denotes Calu-3 CVCL:0609

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T424 0-183 Sentence denotes Observation of agglutination of human erythrocytes by intact MERS-CoV particles led to the finding that Sia-binding activity of MERS-CoV is mediated by multivalent S1A (S1-NTD) [112].
T425 184-352 Sentence denotes One hundred thirty-five glycan structures were used for determination of receptor binding specificity of multivalent MERS-S1A-containing nanoparticles by glycan arrays.
T426 353-479 Sentence denotes It appeared that MERS-S1A nanoparticles bind selectively to nonmodified Neu5Ac but not to Neu5Gc or (7,)9-O-acetylated Neu5Ac.
T427 480-669 Sentence denotes No binding to Neu5Gc-terminated glycans was explained by steric hindrance of the extra hydroxyl group of Neu5Gc in the MERS- S1A hydrophobic pocket formed by F39, F101, I131 and I132 [148].
T428 670-867 Sentence denotes For sialyl linkage specificity, MERS-CoV S1A prefers α2,3 over α2,6 linkages, either short, sulfated, α2,3-linked mono-Sia LewisX or long, branched, α2,3-linked tri-Sia with four type 2 LN repeats.
T429 868-1018 Sentence denotes Pretreatment of Calu-3 human airway cells with neuraminidase inhibited infection of MERS-CoV, indicating that Sia is necessary for MERS-CoV infection.
T430 1019-1388 Sentence denotes Accordingly, multivalent MERS-CoV S1A-containing nanoparticles were shown to specifically bind to infection sites in individual hosts: dromedary camel nasal epithelial cells, human type II pneumocytes in the alveolar wall that contains an abundance of α2,3-sialyl type 2 LN and a small amount of α2,3-sialyl-LewisX [19], and pipistrelle bat intestinal epithelial cells.
T431 1389-1581 Sentence denotes Removal of Sia from cell surface glycans by treatment with neuraminidase abolished binding of the nanoparticles, confirming that MERS-CoV S1A binds to infected cells via Sia recognition [108].
T432 1582-1648 Sentence denotes The cryo-EM structure of MERS-CoV S in complex with α2,3-SLN (pdb:
T433 1649-1746 Sentence denotes 6q06) showed Sia binding in a surface-exposed groove (domain A) of each monomer (Figure 9, left).
T434 1747-1891 Sentence denotes Analysis of the structure indicated the five residues Q36, A92, I132, S133 and R307 directly anchoring Neu5Ac as shown in Figure 9, right [148].