PMC:7712180 / 50972-51239 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7712180","sourcedb":"PMC","sourceid":"7712180","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7712180","text":"Mutations in hAPN, D288A, Y289A, V290G, I309A and L318A, resulted in hAPN binding affinity to HCoV-229E RBD, and the V290G mutant showed the greatest reduction (30-fold reduction) of binding affinity, indicating receptor binding specificity of the HCoV-229E RBD [83].","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1642","span":{"begin":13,"end":17},"obj":"Gene"},{"id":"1643","span":{"begin":69,"end":73},"obj":"Gene"},{"id":"1661","span":{"begin":94,"end":103},"obj":"Species"},{"id":"1662","span":{"begin":248,"end":257},"obj":"Species"},{"id":"1668","span":{"begin":19,"end":24},"obj":"Mutation"},{"id":"1669","span":{"begin":26,"end":31},"obj":"Mutation"},{"id":"1670","span":{"begin":117,"end":122},"obj":"Mutation"},{"id":"1671","span":{"begin":40,"end":45},"obj":"Mutation"},{"id":"1672","span":{"begin":50,"end":55},"obj":"Mutation"},{"id":"1673","span":{"begin":33,"end":38},"obj":"Mutation"}],"attributes":[{"id":"A1642","pred":"tao:has_database_id","subj":"1642","obj":"Gene:290"},{"id":"A1643","pred":"tao:has_database_id","subj":"1643","obj":"Gene:290"},{"id":"A1661","pred":"tao:has_database_id","subj":"1661","obj":"Tax:11137"},{"id":"A1662","pred":"tao:has_database_id","subj":"1662","obj":"Tax:11137"},{"id":"A1668","pred":"tao:has_standard_notation","subj":"1668","obj":"p.D288A"},{"id":"A1669","pred":"tao:has_standard_notation","subj":"1669","obj":"p.Y289A"},{"id":"A1670","pred":"tao:has_standard_notation","subj":"1670","obj":"p.V290G"},{"id":"A1671","pred":"tao:has_standard_notation","subj":"1671","obj":"p.I309A"},{"id":"A1672","pred":"tao:has_standard_notation","subj":"1672","obj":"p.L318A"},{"id":"A1673","pred":"tao:has_standard_notation","subj":"1673","obj":"p.V290G"},{"subj":"1642","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1643","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1661","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1662","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1668","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1669","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1670","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1671","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1672","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1673","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T270","span":{"begin":0,"end":267},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T270","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#afec93","default":true},{"id":"LitCovid-sentences","color":"#ec93c9"}]}]}}