PMC:7712180 / 45444-46611 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1503","span":{"begin":432,"end":437},"obj":"Gene"},{"id":"1504","span":{"begin":20,"end":29},"obj":"Species"},{"id":"1505","span":{"begin":267,"end":270},"obj":"Species"},{"id":"1506","span":{"begin":334,"end":343},"obj":"Species"},{"id":"1507","span":{"begin":361,"end":364},"obj":"Species"},{"id":"1508","span":{"begin":566,"end":569},"obj":"Species"},{"id":"1509","span":{"begin":890,"end":895},"obj":"Species"},{"id":"1510","span":{"begin":900,"end":905},"obj":"Species"},{"id":"1511","span":{"begin":58,"end":62},"obj":"Species"},{"id":"1512","span":{"begin":262,"end":266},"obj":"Species"},{"id":"1513","span":{"begin":356,"end":360},"obj":"Species"},{"id":"1514","span":{"begin":285,"end":317},"obj":"Disease"},{"id":"1515","span":{"begin":378,"end":405},"obj":"Disease"},{"id":"1516","span":{"begin":985,"end":994},"obj":"Disease"},{"id":"1517","span":{"begin":1123,"end":1166},"obj":"Disease"}],"attributes":[{"id":"A1503","pred":"tao:has_database_id","subj":"1503","obj":"Gene:43740568"},{"id":"A1504","pred":"tao:has_database_id","subj":"1504","obj":"Tax:277944"},{"id":"A1505","pred":"tao:has_database_id","subj":"1505","obj":"Tax:11118"},{"id":"A1506","pred":"tao:has_database_id","subj":"1506","obj":"Tax:11137"},{"id":"A1507","pred":"tao:has_database_id","subj":"1507","obj":"Tax:11118"},{"id":"A1508","pred":"tao:has_database_id","subj":"1508","obj":"Tax:11118"},{"id":"A1509","pred":"tao:has_database_id","subj":"1509","obj":"Tax:9838"},{"id":"A1510","pred":"tao:has_database_id","subj":"1510","obj":"Tax:9606"},{"id":"A1511","pred":"tao:has_database_id","subj":"1511","obj":"Tax:11137"},{"id":"A1512","pred":"tao:has_database_id","subj":"1512","obj":"Tax:11137"},{"id":"A1513","pred":"tao:has_database_id","subj":"1513","obj":"Tax:11137"},{"id":"A1514","pred":"tao:has_database_id","subj":"1514","obj":"MESH:D004067"},{"id":"A1515","pred":"tao:has_database_id","subj":"1515","obj":"MESH:D012141"},{"id":"A1516","pred":"tao:has_database_id","subj":"1516","obj":"MESH:D007239"},{"id":"A1517","pred":"tao:has_database_id","subj":"1517","obj":"MESH:D012818"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"As in the case of α HCoV-NL63 virus shown in Figure 6a, α 229E viruses use their S1-CTDs on the top center of each S1 monomer of the S trimer to bind to host receptors. It is notable that about 396 amino acids at the N-terminus of the S protein of ancestral bat-229E CoV, which causes gastrointestinal tract infection, are deleted in HCoV-229E and camelid-229E CoV, which cause respiratory tract infection. Although this N-terminal spike deletion is not involved in the receptor binding site (RBS), it was presumed that the deletion is associated with the change in CoV tissue tropism from the gastrointestinal tract to the respiratory tract [203]. Further studies on its location on the spike 3D structure and on the mechanism of its function, which is thought to support virus replication in the bat gastrointestinal tract, as well as how the deletion helps the virus to replicate in the camel and human respiratory tracts may lead to an understanding of the molecular mechanisms of infection in the gastrointestinal and respiratory tracts. An understanding of the molecular mechanisms might lead to future prevention of gastrointestinal and respiratory infections."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T11","span":{"begin":378,"end":405},"obj":"Phenotype"},{"id":"T12","span":{"begin":1144,"end":1166},"obj":"Phenotype"}],"attributes":[{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0011947"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0011947"}],"text":"As in the case of α HCoV-NL63 virus shown in Figure 6a, α 229E viruses use their S1-CTDs on the top center of each S1 monomer of the S trimer to bind to host receptors. It is notable that about 396 amino acids at the N-terminus of the S protein of ancestral bat-229E CoV, which causes gastrointestinal tract infection, are deleted in HCoV-229E and camelid-229E CoV, which cause respiratory tract infection. Although this N-terminal spike deletion is not involved in the receptor binding site (RBS), it was presumed that the deletion is associated with the change in CoV tissue tropism from the gastrointestinal tract to the respiratory tract [203]. Further studies on its location on the spike 3D structure and on the mechanism of its function, which is thought to support virus replication in the bat gastrointestinal tract, as well as how the deletion helps the virus to replicate in the camel and human respiratory tracts may lead to an understanding of the molecular mechanisms of infection in the gastrointestinal and respiratory tracts. An understanding of the molecular mechanisms might lead to future prevention of gastrointestinal and respiratory infections."}

{"project":"LitCovid-sentences","denotations":[{"id":"T246","span":{"begin":0,"end":168},"obj":"Sentence"},{"id":"T247","span":{"begin":169,"end":406},"obj":"Sentence"},{"id":"T248","span":{"begin":407,"end":648},"obj":"Sentence"},{"id":"T249","span":{"begin":649,"end":1042},"obj":"Sentence"},{"id":"T250","span":{"begin":1043,"end":1167},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"As in the case of α HCoV-NL63 virus shown in Figure 6a, α 229E viruses use their S1-CTDs on the top center of each S1 monomer of the S trimer to bind to host receptors. It is notable that about 396 amino acids at the N-terminus of the S protein of ancestral bat-229E CoV, which causes gastrointestinal tract infection, are deleted in HCoV-229E and camelid-229E CoV, which cause respiratory tract infection. Although this N-terminal spike deletion is not involved in the receptor binding site (RBS), it was presumed that the deletion is associated with the change in CoV tissue tropism from the gastrointestinal tract to the respiratory tract [203]. Further studies on its location on the spike 3D structure and on the mechanism of its function, which is thought to support virus replication in the bat gastrointestinal tract, as well as how the deletion helps the virus to replicate in the camel and human respiratory tracts may lead to an understanding of the molecular mechanisms of infection in the gastrointestinal and respiratory tracts. An understanding of the molecular mechanisms might lead to future prevention of gastrointestinal and respiratory infections."}