PMC:7712180 / 42179-43632 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1396","span":{"begin":423,"end":431},"obj":"Gene"},{"id":"1397","span":{"begin":162,"end":167},"obj":"Species"},{"id":"1398","span":{"begin":182,"end":187},"obj":"Species"},{"id":"1399","span":{"begin":205,"end":210},"obj":"Species"},{"id":"1400","span":{"begin":379,"end":388},"obj":"Species"},{"id":"1401","span":{"begin":786,"end":790},"obj":"Species"},{"id":"1402","span":{"begin":795,"end":799},"obj":"Species"},{"id":"1403","span":{"begin":809,"end":817},"obj":"Species"},{"id":"1404","span":{"begin":910,"end":914},"obj":"Species"},{"id":"1405","span":{"begin":920,"end":926},"obj":"Species"},{"id":"1406","span":{"begin":997,"end":1001},"obj":"Species"},{"id":"1407","span":{"begin":1140,"end":1146},"obj":"Species"},{"id":"1408","span":{"begin":1188,"end":1194},"obj":"Species"},{"id":"1409","span":{"begin":1219,"end":1223},"obj":"Species"},{"id":"1410","span":{"begin":1228,"end":1235},"obj":"Species"},{"id":"1411","span":{"begin":9,"end":14},"obj":"Species"},{"id":"1412","span":{"begin":226,"end":232},"obj":"Disease"},{"id":"1413","span":{"begin":547,"end":563},"obj":"Disease"},{"id":"1414","span":{"begin":688,"end":704},"obj":"Disease"},{"id":"1415","span":{"begin":861,"end":876},"obj":"Disease"},{"id":"1416","span":{"begin":897,"end":906},"obj":"Disease"},{"id":"1417","span":{"begin":1147,"end":1156},"obj":"Disease"},{"id":"1418","span":{"begin":168,"end":174},"obj":"CellLine"},{"id":"1419","span":{"begin":188,"end":194},"obj":"CellLine"}],"attributes":[{"id":"A1396","pred":"tao:has_database_id","subj":"1396","obj":"Gene:3122"},{"id":"A1397","pred":"tao:has_database_id","subj":"1397","obj":"Tax:9606"},{"id":"A1398","pred":"tao:has_database_id","subj":"1398","obj":"Tax:9606"},{"id":"A1399","pred":"tao:has_database_id","subj":"1399","obj":"Tax:9606"},{"id":"A1400","pred":"tao:has_database_id","subj":"1400","obj":"Tax:9606"},{"id":"A1401","pred":"tao:has_database_id","subj":"1401","obj":"Tax:9823"},{"id":"A1402","pred":"tao:has_database_id","subj":"1402","obj":"Tax:10090"},{"id":"A1403","pred":"tao:has_database_id","subj":"1403","obj":"Tax:9031"},{"id":"A1404","pred":"tao:has_database_id","subj":"1404","obj":"Tax:10090"},{"id":"A1405","pred":"tao:has_database_id","subj":"1405","obj":"Tax:1249503"},{"id":"A1406","pred":"tao:has_database_id","subj":"1406","obj":"Tax:10090"},{"id":"A1407","pred":"tao:has_database_id","subj":"1407","obj":"Tax:1249503"},{"id":"A1408","pred":"tao:has_database_id","subj":"1408","obj":"Tax:1249503"},{"id":"A1409","pred":"tao:has_database_id","subj":"1409","obj":"Tax:10090"},{"id":"A1410","pred":"tao:has_database_id","subj":"1410","obj":"Tax:9669"},{"id":"A1411","pred":"tao:has_database_id","subj":"1411","obj":"Tax:9606"},{"id":"A1412","pred":"tao:has_database_id","subj":"1412","obj":"MESH:D009369"},{"id":"A1413","pred":"tao:has_database_id","subj":"1413","obj":"MESH:D001102"},{"id":"A1414","pred":"tao:has_database_id","subj":"1414","obj":"MESH:D001102"},{"id":"A1415","pred":"tao:has_database_id","subj":"1415","obj":"MESH:D001102"},{"id":"A1416","pred":"tao:has_database_id","subj":"1416","obj":"MESH:D007239"},{"id":"A1417","pred":"tao:has_database_id","subj":"1417","obj":"MESH:D007239"},{"id":"A1418","pred":"tao:has_database_id","subj":"1418","obj":"CVCL:0022"},{"id":"A1419","pred":"tao:has_database_id","subj":"1419","obj":"CVCL:0609"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In 2019, human leukocyte antigen DR (HLA-DR) isotype, one of the three major MHC class II isotypes, found on susceptible cell lines including MDCKII clone no. 1, human U-87MG cells, human Calu-3 cells and human haematopoietic cancer cells was shown by the following findings to be required for mediating entry of pseudotyped viruses harboring H17 HAs [63] or H18 HAs [62] into a mammalian cell: (i) knockdown of HLA-DRA or HLA-DR α-chain or cell preincubation with an HLA-DRA-targeting antibody significantly reduced both H17- and H18-pseudotyped virus infections, (ii) ectopic expression of HLA-DR in non-susceptible cell lines rendered them susceptible to both H17- and H18-pseudotyped virus infections, (iii) expression of HLA-DR from other mammals, including different bat species, pigs and mice, or from chickens makes cells susceptible to H18-pseudotyped virus infection and (iv) intranasal infection of mice with H18N11 virus led to viral replication in the upper respiratory tracts of the mice. While these findings suggested possible spread of bat H17 and H18 viruses to other vertebrates, recent studies have shown that wild-type H18N11 infection is restricted to bats and that H18N11 has poor replication in mice and ferrets [199]. The potential of these viruses to spread to and infect other animals and the tissue tropism within other animals remain unclear. Characterization of direct binding of H17 and H18 HAs to MHC-II is also required."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T9","span":{"begin":226,"end":232},"obj":"Phenotype"}],"attributes":[{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"In 2019, human leukocyte antigen DR (HLA-DR) isotype, one of the three major MHC class II isotypes, found on susceptible cell lines including MDCKII clone no. 1, human U-87MG cells, human Calu-3 cells and human haematopoietic cancer cells was shown by the following findings to be required for mediating entry of pseudotyped viruses harboring H17 HAs [63] or H18 HAs [62] into a mammalian cell: (i) knockdown of HLA-DRA or HLA-DR α-chain or cell preincubation with an HLA-DRA-targeting antibody significantly reduced both H17- and H18-pseudotyped virus infections, (ii) ectopic expression of HLA-DR in non-susceptible cell lines rendered them susceptible to both H17- and H18-pseudotyped virus infections, (iii) expression of HLA-DR from other mammals, including different bat species, pigs and mice, or from chickens makes cells susceptible to H18-pseudotyped virus infection and (iv) intranasal infection of mice with H18N11 virus led to viral replication in the upper respiratory tracts of the mice. While these findings suggested possible spread of bat H17 and H18 viruses to other vertebrates, recent studies have shown that wild-type H18N11 infection is restricted to bats and that H18N11 has poor replication in mice and ferrets [199]. The potential of these viruses to spread to and infect other animals and the tissue tropism within other animals remain unclear. Characterization of direct binding of H17 and H18 HAs to MHC-II is also required."}

{"project":"LitCovid-sentences","denotations":[{"id":"T234","span":{"begin":0,"end":158},"obj":"Sentence"},{"id":"T235","span":{"begin":159,"end":1002},"obj":"Sentence"},{"id":"T236","span":{"begin":1003,"end":1242},"obj":"Sentence"},{"id":"T237","span":{"begin":1243,"end":1371},"obj":"Sentence"},{"id":"T238","span":{"begin":1372,"end":1453},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In 2019, human leukocyte antigen DR (HLA-DR) isotype, one of the three major MHC class II isotypes, found on susceptible cell lines including MDCKII clone no. 1, human U-87MG cells, human Calu-3 cells and human haematopoietic cancer cells was shown by the following findings to be required for mediating entry of pseudotyped viruses harboring H17 HAs [63] or H18 HAs [62] into a mammalian cell: (i) knockdown of HLA-DRA or HLA-DR α-chain or cell preincubation with an HLA-DRA-targeting antibody significantly reduced both H17- and H18-pseudotyped virus infections, (ii) ectopic expression of HLA-DR in non-susceptible cell lines rendered them susceptible to both H17- and H18-pseudotyped virus infections, (iii) expression of HLA-DR from other mammals, including different bat species, pigs and mice, or from chickens makes cells susceptible to H18-pseudotyped virus infection and (iv) intranasal infection of mice with H18N11 virus led to viral replication in the upper respiratory tracts of the mice. While these findings suggested possible spread of bat H17 and H18 viruses to other vertebrates, recent studies have shown that wild-type H18N11 infection is restricted to bats and that H18N11 has poor replication in mice and ferrets [199]. The potential of these viruses to spread to and infect other animals and the tissue tropism within other animals remain unclear. Characterization of direct binding of H17 and H18 HAs to MHC-II is also required."}