PMC:7712180 / 34439-35855 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1185","span":{"begin":0,"end":9},"obj":"Species"},{"id":"1186","span":{"begin":104,"end":121},"obj":"Species"},{"id":"1187","span":{"begin":125,"end":131},"obj":"Species"},{"id":"1188","span":{"begin":132,"end":135},"obj":"Species"},{"id":"1189","span":{"begin":143,"end":152},"obj":"Species"},{"id":"1190","span":{"begin":177,"end":182},"obj":"Species"},{"id":"1191","span":{"begin":365,"end":374},"obj":"Species"},{"id":"1192","span":{"begin":379,"end":388},"obj":"Species"},{"id":"1193","span":{"begin":668,"end":677},"obj":"Species"},{"id":"1194","span":{"begin":682,"end":691},"obj":"Species"},{"id":"1195","span":{"begin":899,"end":905},"obj":"Species"},{"id":"1196","span":{"begin":1012,"end":1021},"obj":"Species"},{"id":"1197","span":{"begin":1026,"end":1035},"obj":"Species"},{"id":"1198","span":{"begin":1039,"end":1044},"obj":"Species"},{"id":"1199","span":{"begin":1206,"end":1211},"obj":"Species"},{"id":"1200","span":{"begin":1345,"end":1354},"obj":"Species"},{"id":"1201","span":{"begin":1359,"end":1368},"obj":"Species"},{"id":"1202","span":{"begin":801,"end":805},"obj":"Species"},{"id":"1203","span":{"begin":857,"end":861},"obj":"Species"},{"id":"1204","span":{"begin":1139,"end":1143},"obj":"Species"},{"id":"1205","span":{"begin":1148,"end":1152},"obj":"Species"},{"id":"1206","span":{"begin":1159,"end":1163},"obj":"Species"},{"id":"1207","span":{"begin":397,"end":411},"obj":"Chemical"},{"id":"1208","span":{"begin":419,"end":426},"obj":"Chemical"},{"id":"1209","span":{"begin":478,"end":493},"obj":"Disease"},{"id":"1210","span":{"begin":1045,"end":1061},"obj":"Disease"},{"id":"1211","span":{"begin":1332,"end":1341},"obj":"Disease"}],"attributes":[{"id":"A1185","pred":"tao:has_database_id","subj":"1185","obj":"Tax:31631"},{"id":"A1186","pred":"tao:has_database_id","subj":"1186","obj":"Tax:11552"},{"id":"A1187","pred":"tao:has_database_id","subj":"1187","obj":"Tax:9913"},{"id":"A1188","pred":"tao:has_database_id","subj":"1188","obj":"Tax:11118"},{"id":"A1189","pred":"tao:has_database_id","subj":"1189","obj":"Tax:290028"},{"id":"A1190","pred":"tao:has_database_id","subj":"1190","obj":"Tax:9606"},{"id":"A1191","pred":"tao:has_database_id","subj":"1191","obj":"Tax:31631"},{"id":"A1192","pred":"tao:has_database_id","subj":"1192","obj":"Tax:290028"},{"id":"A1193","pred":"tao:has_database_id","subj":"1193","obj":"Tax:31631"},{"id":"A1194","pred":"tao:has_database_id","subj":"1194","obj":"Tax:290028"},{"id":"A1195","pred":"tao:has_database_id","subj":"1195","obj":"Tax:9606"},{"id":"A1196","pred":"tao:has_database_id","subj":"1196","obj":"Tax:31631"},{"id":"A1197","pred":"tao:has_database_id","subj":"1197","obj":"Tax:290028"},{"id":"A1198","pred":"tao:has_database_id","subj":"1198","obj":"Tax:9606"},{"id":"A1199","pred":"tao:has_database_id","subj":"1199","obj":"Tax:11145"},{"id":"A1200","pred":"tao:has_database_id","subj":"1200","obj":"Tax:31631"},{"id":"A1201","pred":"tao:has_database_id","subj":"1201","obj":"Tax:290028"},{"id":"A1202","pred":"tao:has_database_id","subj":"1202","obj":"Tax:31631"},{"id":"A1203","pred":"tao:has_database_id","subj":"1203","obj":"Tax:290028"},{"id":"A1204","pred":"tao:has_database_id","subj":"1204","obj":"Tax:290028"},{"id":"A1205","pred":"tao:has_database_id","subj":"1205","obj":"Tax:31631"},{"id":"A1206","pred":"tao:has_database_id","subj":"1206","obj":"Tax:11128"},{"id":"A1208","pred":"tao:has_database_id","subj":"1208","obj":"MESH:D011134"},{"id":"A1209","pred":"tao:has_database_id","subj":"1209","obj":"MESH:D001102"},{"id":"A1210","pred":"tao:has_database_id","subj":"1210","obj":"MESH:D012208"},{"id":"A1211","pred":"tao:has_database_id","subj":"1211","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"HCoV-OC43 does not bind to and agglutinate erythrocytes pretreated with 9-O-acetyl esterase from either influenza C virus or bovine CoV [190]. HCoV-HKU1 does not infect primary human ciliated airway epithelial cells pretreated with an expressed HKU1 hemagglutinin-esterase (HE) protein possessing 9-O-acetylesterase activity [191]. These findings suggest that both HCoV-OC43 and HCoV-HKU1 bind to 9-O-acetylated sialyl glycans (Figure 4a) on the host cell surface for mediating virus infection. As shown in Table 2, the 9-O-Ac-Sia receptor-binding function of homodimeric HE proteins, comprised of a receptor-binding (lectin) domain and receptor-destroying domain, of HCoV-OC43 and HCoV-HKU1 was reported to be lost, and its loss was reported to be associated with an accumulation of mutations in the OC43-HE lectin domain or massive deletions found in the HKU1-HE lectin domain during evolution in humans [94]. Binding of the S1 subunit of another type of spike, a homotrimeric spike (S) protein (Figure 2), of HCoV-OC43 and HCoV-HKU1 on human rhabdomyosarcoma cells was shown and was reported to be reduced by pretreating the cells with HKU1-HE, OC43-HE or BCoV-HE, but not by pretreating the cells with MHV-S-HE, possessing 4-O-acetylesterase activity [191]. These findings suggested that 9-O-Ac-Sia is an essential receptor for infection of HCoV-OC43 and HCoV-HKU1 mediated by the S1 subunit of their S proteins."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T8","span":{"begin":1045,"end":1061},"obj":"Phenotype"}],"attributes":[{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002859"}],"text":"HCoV-OC43 does not bind to and agglutinate erythrocytes pretreated with 9-O-acetyl esterase from either influenza C virus or bovine CoV [190]. HCoV-HKU1 does not infect primary human ciliated airway epithelial cells pretreated with an expressed HKU1 hemagglutinin-esterase (HE) protein possessing 9-O-acetylesterase activity [191]. These findings suggest that both HCoV-OC43 and HCoV-HKU1 bind to 9-O-acetylated sialyl glycans (Figure 4a) on the host cell surface for mediating virus infection. As shown in Table 2, the 9-O-Ac-Sia receptor-binding function of homodimeric HE proteins, comprised of a receptor-binding (lectin) domain and receptor-destroying domain, of HCoV-OC43 and HCoV-HKU1 was reported to be lost, and its loss was reported to be associated with an accumulation of mutations in the OC43-HE lectin domain or massive deletions found in the HKU1-HE lectin domain during evolution in humans [94]. Binding of the S1 subunit of another type of spike, a homotrimeric spike (S) protein (Figure 2), of HCoV-OC43 and HCoV-HKU1 on human rhabdomyosarcoma cells was shown and was reported to be reduced by pretreating the cells with HKU1-HE, OC43-HE or BCoV-HE, but not by pretreating the cells with MHV-S-HE, possessing 4-O-acetylesterase activity [191]. These findings suggested that 9-O-Ac-Sia is an essential receptor for infection of HCoV-OC43 and HCoV-HKU1 mediated by the S1 subunit of their S proteins."}

{"project":"LitCovid-sentences","denotations":[{"id":"T199","span":{"begin":0,"end":142},"obj":"Sentence"},{"id":"T200","span":{"begin":143,"end":331},"obj":"Sentence"},{"id":"T201","span":{"begin":332,"end":494},"obj":"Sentence"},{"id":"T202","span":{"begin":495,"end":911},"obj":"Sentence"},{"id":"T203","span":{"begin":912,"end":1261},"obj":"Sentence"},{"id":"T204","span":{"begin":1262,"end":1416},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"HCoV-OC43 does not bind to and agglutinate erythrocytes pretreated with 9-O-acetyl esterase from either influenza C virus or bovine CoV [190]. HCoV-HKU1 does not infect primary human ciliated airway epithelial cells pretreated with an expressed HKU1 hemagglutinin-esterase (HE) protein possessing 9-O-acetylesterase activity [191]. These findings suggest that both HCoV-OC43 and HCoV-HKU1 bind to 9-O-acetylated sialyl glycans (Figure 4a) on the host cell surface for mediating virus infection. As shown in Table 2, the 9-O-Ac-Sia receptor-binding function of homodimeric HE proteins, comprised of a receptor-binding (lectin) domain and receptor-destroying domain, of HCoV-OC43 and HCoV-HKU1 was reported to be lost, and its loss was reported to be associated with an accumulation of mutations in the OC43-HE lectin domain or massive deletions found in the HKU1-HE lectin domain during evolution in humans [94]. Binding of the S1 subunit of another type of spike, a homotrimeric spike (S) protein (Figure 2), of HCoV-OC43 and HCoV-HKU1 on human rhabdomyosarcoma cells was shown and was reported to be reduced by pretreating the cells with HKU1-HE, OC43-HE or BCoV-HE, but not by pretreating the cells with MHV-S-HE, possessing 4-O-acetylesterase activity [191]. These findings suggested that 9-O-Ac-Sia is an essential receptor for infection of HCoV-OC43 and HCoV-HKU1 mediated by the S1 subunit of their S proteins."}