PMC:7712180 / 25938-27023 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
909	570-577	Gene	denotes	α2,3Sia	Gene:170589
910	582-589	Gene	denotes	α2,6Sia	Gene:170589
911	737-744	Gene	denotes	α2,3Sia	Gene:170589
912	749-756	Gene	denotes	α2,6Sia	Gene:170589
913	706-708	Gene	denotes	α2	Gene:170589
914	247-249	Gene	denotes	α2	Gene:170589
915	236-241	Species	denotes	human	Tax:9606
916	512-519	Gene	denotes	α2,6Sia	Gene:170589
917	449-456	Gene	denotes	α2,6Sia	Gene:170589
918	500-502	Gene	denotes	α2	Gene:170589
919	52-67	Disease	denotes	virus infection	MESH:D001102
920	810-826	Disease	denotes	bronchopneumonia	MESH:D001996
921	831-856	Disease	denotes	gastrointestinal symptoms	MESH:D012817

Id	Subject	Object	Predicate	Lexical cue
T153	0-68	Sentence	denotes	Receptor binding specificity determines the site of virus infection.
T154	69-268	Sentence	denotes	It appears that wild-type influenza B/Victoria HAs possessing G141, R162 and D196 [67] and B/Yamagata HAs with F95 and N194 [68] clearly exhibit binding preference to human-type α2,6Neu5Ac receptors.
T155	269-714	Sentence	denotes	Investigation of receptor binding preference of IBV clinical isolates in Taiwan during the period from 2001 to 2007 (Table 1) revealed that (i) 83% of Yamagata-like strains prefer α2,6Sia receptors, whereas 17% of them prefer both α2,3Sia and α2,6Sia and (ii) 54% of Victoria-like strains prefer both α2,3Sia and α2,6Sia, whereas 25% of them prefer sulfated glycan, either β-Gal-3-sulfate or 6-HSO3-Galβ1,4GlcNAc, and 21% of them prefer α2,6Sia.
T156	715-862	Sentence	denotes	The viruses with dual α2,3Sia and α2,6Sia-binding preferences were shown to be associated with bronchopneumonia and gastrointestinal symptoms [66].
T157	863-1085	Sentence	denotes	These findings indicate that the evolution of receptor binding specificity in IBVs in circulation is different from that in IAVs and indicate tissue tropism and pathogenicity of IBVs, possibly affecting virus transmission.