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PMC:7712180 / 24233-27023 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
847 29-38 Gene denotes Siaα2,3/2
872 1446-1450 Gene denotes Neu1 Gene:4758
873 1451-1455 Gene denotes Neu4 Gene:129807
874 81-98 Species denotes influenza viruses Tax:11308
875 741-745 Species denotes H3N2 Tax:119210
876 763-767 Species denotes H1N1 Tax:114727
877 817-823 Species denotes humans Tax:9606
878 888-892 Species denotes pigs Tax:9823
879 894-900 Species denotes horses Tax:9796
880 916-920 Species denotes dogs Tax:9615
881 1440-1445 Species denotes human Tax:9606
882 644-653 Species denotes influenza Tax:11520
883 1363-1372 Species denotes influenza Tax:11520
884 1620-1629 Species denotes influenza Tax:11520
885 241-247 Species denotes humans Tax:9606
886 1172-1181 Chemical denotes zanamivir MESH:D053243
887 1183-1194 Chemical denotes oseltamivir MESH:D053139
888 1196-1207 Chemical denotes laninamivir MESH:C546918
889 1212-1221 Chemical denotes peramivir MESH:C414210
890 1586-1601 Chemical denotes povidone-iodine MESH:D011206
891 218-237 Disease denotes respiratory disease MESH:D012140
892 614-623 Disease denotes mortality MESH:D003643
893 864-877 Disease denotes IBV infection MESH:D007239
894 1253-1262 Disease denotes infection MESH:D007239
895 1542-1562 Disease denotes Psidium guajava Linn
909 2275-2282 Gene denotes α2,3Sia Gene:170589
910 2287-2294 Gene denotes α2,6Sia Gene:170589
911 2442-2449 Gene denotes α2,3Sia Gene:170589
912 2454-2461 Gene denotes α2,6Sia Gene:170589
913 2411-2413 Gene denotes α2 Gene:170589
914 1952-1954 Gene denotes α2 Gene:170589
915 1941-1946 Species denotes human Tax:9606
916 2217-2224 Gene denotes α2,6Sia Gene:170589
917 2154-2161 Gene denotes α2,6Sia Gene:170589
918 2205-2207 Gene denotes α2 Gene:170589
919 1757-1772 Disease denotes virus infection MESH:D001102
920 2515-2531 Disease denotes bronchopneumonia MESH:D001996
921 2536-2561 Disease denotes gastrointestinal symptoms MESH:D012817

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T142 0-4 Sentence denotes 3.3.
T143 5-53 Sentence denotes Influenza B Viruses Use Siaα2,3/2,6Gal Receptors
T144 54-134 Sentence denotes In 1940, a new serotype of influenza viruses was isolated and designated type B.
T145 135-173 Sentence denotes The first strain was named B/Lee/1940.
T146 174-270 Sentence denotes Influenza B viruses have continued to cause respiratory disease in humans with antigenic change.
T147 271-585 Sentence denotes Although HA and NA antigenic differences within influenza B viruses (IBVs) are not sufficient to separate antigenic subtypes, there were sufficient antigenic differences to classify IBVs into two lineages: (i) Victoria lineage B/Victoria/2/1987-like and (ii) Yamagata lineage B/Yamagata/16/1988-like viruses [170].
T148 586-776 Sentence denotes Consequently, morbidity and mortality-associated seasonal influenza is currently caused by the two lineages of IBVs and two subtypes of IAVs, 1968-derived H3N2 and 2009-derived H1N1 viruses.
T149 777-926 Sentence denotes In contrast to IAVs, IBVs infect mainly humans, although there are sporadic reports of IBV infection in seals, pigs, horses, pheasants and dogs [65].
T150 927-1119 Sentence denotes Similar to IAVs, IBVs have eight (-)ssRNA genome segments and possess receptor-binding and -destroying activities on different molecules, homo-trimeric HA and homo-tetrameric NA glycoproteins.
T151 1120-1302 Sentence denotes Clinically approved NA inhibitors (NAIs), including zanamivir, oseltamivir, laninamivir and peramivir, are now used for treatment of infection with not only IAVs but also IBVs [171].
T152 1303-1704 Sentence denotes Several chemical compounds that have been developed as anti-influenza A NAs, including Neu5Ac2en mimetics for minimizing side effects on human Neu1-Neu4 enzymes [172,173] and NA covalent inhibitors for irreversible NA inhibition [174] and Psidium guajava Linn. (guava) tea [175] and povidone-iodine that possess anti-influenza A sialidase activities [176] might be able to inhibit influenza B viruses.
T153 1705-1773 Sentence denotes Receptor binding specificity determines the site of virus infection.
T154 1774-1973 Sentence denotes It appears that wild-type influenza B/Victoria HAs possessing G141, R162 and D196 [67] and B/Yamagata HAs with F95 and N194 [68] clearly exhibit binding preference to human-type α2,6Neu5Ac receptors.
T155 1974-2419 Sentence denotes Investigation of receptor binding preference of IBV clinical isolates in Taiwan during the period from 2001 to 2007 (Table 1) revealed that (i) 83% of Yamagata-like strains prefer α2,6Sia receptors, whereas 17% of them prefer both α2,3Sia and α2,6Sia and (ii) 54% of Victoria-like strains prefer both α2,3Sia and α2,6Sia, whereas 25% of them prefer sulfated glycan, either β-Gal-3-sulfate or 6-HSO3-Galβ1,4GlcNAc, and 21% of them prefer α2,6Sia.
T156 2420-2567 Sentence denotes The viruses with dual α2,3Sia and α2,6Sia-binding preferences were shown to be associated with bronchopneumonia and gastrointestinal symptoms [66].
T157 2568-2790 Sentence denotes These findings indicate that the evolution of receptor binding specificity in IBVs in circulation is different from that in IAVs and indicate tissue tropism and pathogenicity of IBVs, possibly affecting virus transmission.