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PMC:7712180 / 18010-19322 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
724 681-686 Gene denotes Gal-2 Gene:3957
725 1042-1044 Gene denotes α2 Gene:170589
726 40-45 Species denotes human Tax:9606
727 150-155 Species denotes human Tax:9606
728 417-422 Species denotes human Tax:9606
729 810-815 Species denotes human Tax:9606
730 951-956 Species denotes human Tax:9606
731 1152-1157 Species denotes human Tax:9606
732 1216-1222 Species denotes humans Tax:9606
733 1007-1012 Mutation denotes L226Q p.L226Q
734 1224-1229 Mutation denotes L226V p.L226V
735 1234-1239 Mutation denotes V226I p.V226I

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T106 0-487 Sentence denotes Structural comparison of avian-type and human-type receptors interacting with the receptor binding sites of avian H3/1963, pandemic (pdm) H3/1968 and human H3/2007 (Figure 3b) revealed that trisaccharide Neu5Acα2,3Galβ1,3GlcNAc of lactoseries tetrasaccharide a (LSTa) interacts with the avian H3/1963 binding site in a cone-like topology (1mqm [149]), whereas 6′SLNLN interacts with pandemic H3/1968 (6tzb [150]) and human H3/2007 binding sites in an umbrella-like topology (6aov [151]).
T107 488-573 Sentence denotes Residues 226 and 228 are important in determining sialyl linkage binding specificity.
T108 574-893 Sentence denotes As shown in Figure 3b, Q226 in the avian H3/1963 binding site directly forms hydrogen bonds with Sia-1 and Gal-2 of LSTa, whereas S228 in the pdm H3/1968 binding site directly forms a hydrogen bond with Sia-1 of 6′SLNLN and S228 in the human H3/2007 binding site directly forms two hydrogen bonds with Sia-1 of 6′SLNLN.
T109 894-1072 Sentence denotes Although no direct interaction of residue 226 in pdm and human H3 HAs was found, a previous study suggested that L226Q mutation in the HA decreases α2,6Neu5Ac binding preference.
T110 1073-1171 Sentence denotes Both G228 and S228 can be found in H3 avian HAs, whereas only S228 is found in human H3 HAs [149].
T111 1172-1312 Sentence denotes L226 is not conserved during circulation in humans; L226V and V226I substitutions were observed before 2001 and in 2004, respectively [160].