PMC:7712180 / 105638-106570 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7712180","sourcedb":"PMC","sourceid":"7712180","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7712180","text":"Binding of MERS-CoV S1-CTD to human DDP4 receptor (pdb: 4l72) and S1-NTD to Siaα2,3Gal receptor (pdb: 6q06). Middle: Cartoon diagram of MERS-CoV S1-CTD (pale green) in complex with human DDP4 (magenta) and surface diagram (red) of MERS-CoV S1-NTD in complex with Siaα2,3Gal receptor (Sia in magenta stick and Gal in yellow stick). Amino acids in the bright orange area of S1-CTD and in the red area of S1-NTD being a DDP4 binding site and a Sia binding site, respectively, are shown in the lower panel. Right: Direct interactions between amino acids of the DDP4 binding site and those of the DDP4 receptor and between amino acids of the Sia binding site and those of a Siaα2,3Gal receptor. The bond distance in angstroms of each direct interaction is shown on the dash lines. Amino acids involved in indirect interactions are highlighted in gray in the lower panel. 4l72, 6q06 and 5x5f are from [251], [148] and [205], respectively.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"4613","span":{"begin":23,"end":26},"obj":"Gene"},{"id":"4614","span":{"begin":263,"end":282},"obj":"Gene"},{"id":"4615","span":{"begin":669,"end":688},"obj":"Gene"},{"id":"4616","span":{"begin":51,"end":54},"obj":"Gene"},{"id":"4617","span":{"begin":148,"end":151},"obj":"Gene"},{"id":"4618","span":{"begin":69,"end":72},"obj":"Gene"},{"id":"4619","span":{"begin":11,"end":19},"obj":"Species"},{"id":"4620","span":{"begin":30,"end":35},"obj":"Species"},{"id":"4621","span":{"begin":136,"end":144},"obj":"Species"},{"id":"4622","span":{"begin":181,"end":186},"obj":"Species"},{"id":"4623","span":{"begin":231,"end":239},"obj":"Species"},{"id":"4624","span":{"begin":405,"end":408},"obj":"Gene"},{"id":"4625","span":{"begin":243,"end":246},"obj":"Gene"}],"attributes":[{"id":"A4613","pred":"tao:has_database_id","subj":"4613","obj":"Gene:1283"},{"id":"A4616","pred":"tao:has_database_id","subj":"4616","obj":"Gene:5131"},{"id":"A4617","pred":"tao:has_database_id","subj":"4617","obj":"Gene:1283"},{"id":"A4618","pred":"tao:has_database_id","subj":"4618","obj":"Gene:80199"},{"id":"A4619","pred":"tao:has_database_id","subj":"4619","obj":"Tax:1335626"},{"id":"A4620","pred":"tao:has_database_id","subj":"4620","obj":"Tax:9606"},{"id":"A4621","pred":"tao:has_database_id","subj":"4621","obj":"Tax:1335626"},{"id":"A4622","pred":"tao:has_database_id","subj":"4622","obj":"Tax:9606"},{"id":"A4623","pred":"tao:has_database_id","subj":"4623","obj":"Tax:1335626"},{"id":"A4624","pred":"tao:has_database_id","subj":"4624","obj":"Gene:80199"},{"id":"A4625","pred":"tao:has_database_id","subj":"4625","obj":"Gene:80199"},{"subj":"4613","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4614","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4615","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4616","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4617","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4618","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4619","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4620","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4621","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4622","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4623","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4624","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4625","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T573","span":{"begin":56,"end":101},"obj":"Sentence"},{"id":"T574","span":{"begin":102,"end":108},"obj":"Sentence"},{"id":"T575","span":{"begin":109,"end":116},"obj":"Sentence"},{"id":"T576","span":{"begin":117,"end":330},"obj":"Sentence"},{"id":"T577","span":{"begin":331,"end":502},"obj":"Sentence"},{"id":"T578","span":{"begin":503,"end":509},"obj":"Sentence"},{"id":"T579","span":{"begin":510,"end":689},"obj":"Sentence"},{"id":"T580","span":{"begin":690,"end":775},"obj":"Sentence"},{"id":"T581","span":{"begin":776,"end":865},"obj":"Sentence"},{"id":"T582","span":{"begin":866,"end":932},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T573","pred":"source","obj":"LitCovid-sentences"},{"subj":"T574","pred":"source","obj":"LitCovid-sentences"},{"subj":"T575","pred":"source","obj":"LitCovid-sentences"},{"subj":"T576","pred":"source","obj":"LitCovid-sentences"},{"subj":"T577","pred":"source","obj":"LitCovid-sentences"},{"subj":"T578","pred":"source","obj":"LitCovid-sentences"},{"subj":"T579","pred":"source","obj":"LitCovid-sentences"},{"subj":"T580","pred":"source","obj":"LitCovid-sentences"},{"subj":"T581","pred":"source","obj":"LitCovid-sentences"},{"subj":"T582","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#9f93ec","default":true},{"id":"LitCovid-sentences","color":"#a0ec93"}]}]}}