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PMC:7696151 / 96155-97932 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2823 81-84 Chemical denotes HCQ MESH:D006886
2824 230-233 Chemical denotes HCQ MESH:D006886
2825 366-369 Chemical denotes HCQ MESH:D006886
2826 766-769 Chemical denotes HCQ MESH:D006886
2827 923-926 Chemical denotes HCQ MESH:D006886
2828 1004-1007 Chemical denotes HCQ MESH:D006886
2829 1090-1107 Chemical denotes 4-aminoquinolines MESH:C001920
2830 1117-1119 Chemical denotes CQ MESH:D002738
2831 1138-1141 Chemical denotes HCQ MESH:D006886
2832 1307-1319 Chemical denotes methotrexate MESH:D008727
2833 1406-1413 Chemical denotes glucose MESH:D005947
2834 1418-1423 Chemical denotes lipid MESH:D008055
2835 1754-1757 Chemical denotes HCQ MESH:D006886
2836 399-411 Disease denotes inflammation MESH:D007249
2837 413-423 Disease denotes infections MESH:D007239
2838 425-444 Disease denotes autoimmune diseases MESH:D001327
2839 446-472 Disease denotes cardiovascular pathologies MESH:D002318
2840 478-486 Disease denotes diabetes MESH:D003920
2841 582-590 Disease denotes COVID-19 MESH:C000657245
2842 637-653 Disease denotes viral infections MESH:D001102
2843 790-798 Disease denotes COVID-19 MESH:C000657245
2844 799-808 Disease denotes infection MESH:D007239
2845 963-971 Disease denotes COVID-19 MESH:C000657245
2846 1187-1206 Disease denotes autoimmune diseases MESH:D001327
2847 1215-1235 Disease denotes rheumatoid arthritis MESH:D001172
2848 1237-1256 Disease denotes lupus erythematosus MESH:D008180
2849 1262-1278 Disease denotes Sjögren syndrome MESH:D012859

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T242 425-444 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960
T243 1187-1206 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960
T244 1215-1235 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T614 0-2 Sentence denotes 4.
T615 3-14 Sentence denotes Conclusions
T616 15-110 Sentence denotes The bubble map of Figure 8 summarizes the pleiotropic activity of HCQ evaluated in this review.
T617 111-271 Sentence denotes As highlighted by the colorimetric variation, the research, in the early 2000s, has been focused on the application of HCQ as an antimalarial drug (blue color).
T618 272-509 Sentence denotes In contrast, in the last few years, scientists have moved their attention to the influence of HCQ on many pathways involved in inflammation, infections, autoimmune diseases, cardiovascular pathologies, and diabetes (blue to green color).
T619 510-669 Sentence denotes Finally, in the last months, it is evident that the rapid spread of the COVID-19 pandemic has led to the revaluation of HCQ in viral infections (yellow color).
T620 670-980 Sentence denotes However, the analysis of currently available clinical studies showed that the administration of HCQ to prevent and cure COVID-19 infection is questionable, since results from clinical trials are contrasting, and the last data did not support the use of HCQ for the treatment and prevention of COVID-19 disease.
T621 981-1120 Sentence denotes Despite these results, HCQ is considered to be a safe drug since it is generally better tolerated than other 4-aminoquinolines, such as CQ.
T622 1121-1388 Sentence denotes Hence, nowadays, HCQ arises as a first-line treatment in managing autoimmune diseases such as rheumatoid arthritis, lupus erythematosus, and Sjögren syndrome, mainly in association with methotrexate or corticosteroids, showing a synergistic effect on disease control.
T623 1389-1508 Sentence denotes It also improves glucose and lipid homeostasis and revealed significant antibacterial activity in combination with DXC.
T624 1509-1673 Sentence denotes To better characterize HCQ activity, computational models should be useful for targeting and docking the molecular features responsible for its mechanism of action.
T625 1674-1777 Sentence denotes Based on this work, it should be possible to hypothesize future applications of HCQ in medical therapy.