PMC:7696151 / 9406-9756 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"230","span":{"begin":35,"end":55},"obj":"Gene"},{"id":"231","span":{"begin":57,"end":62},"obj":"Gene"},{"id":"232","span":{"begin":323,"end":328},"obj":"Gene"},{"id":"240","span":{"begin":233,"end":236},"obj":"Species"},{"id":"242","span":{"begin":158,"end":161},"obj":"Chemical"},{"id":"245","span":{"begin":125,"end":138},"obj":"Disease"}],"attributes":[{"id":"A230","pred":"tao:has_database_id","subj":"230","obj":"Gene:7099"},{"id":"A231","pred":"tao:has_database_id","subj":"231","obj":"Gene:7099"},{"id":"A232","pred":"tao:has_database_id","subj":"232","obj":"Gene:3700"},{"id":"A240","pred":"tao:has_database_id","subj":"240","obj":"Tax:12721"},{"id":"A242","pred":"tao:has_database_id","subj":"242","obj":"MESH:D006886"},{"id":"A245","pred":"tao:has_database_id","subj":"245","obj":"MESH:D015658"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ough the binding and activation of Toll-like receptor 4 (TLR-4), is responsible for the immune system activation observed in HIV infection. Although the real HCQ mechanism of action has not been well assessed, it seems that the anti-HIV effects are highly linked to the post-translational modification of glycoprotein 120 (gp120) in monocyte and T ce"}