PMC:7696151 / 92846-93674 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
2786	429-432	Species	denotes	SAR	Tax:2698737
2787	332-335	Chemical	denotes	HCQ	MESH:D006886
2788	524-532	Disease	denotes	COVID-19	MESH:C000657245
2789	536-541	Disease	denotes	fever	MESH:D005334
2790	543-560	Disease	denotes	Whipple’s disease	MESH:D008061
2791	639-647	Disease	denotes	toxicity	MESH:D064420

Id	Subject	Object	Predicate	Lexical cue	hp_id
T241	536-541	Phenotype	denotes	fever	http://purl.obolibrary.org/obo/HP_0001945

Id	Subject	Object	Predicate	Lexical cue
T592	0-4	Sentence	denotes	3.1.
T593	5-20	Sentence	denotes	Search Strategy
T594	21-229	Sentence	denotes	According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature search was performed in May 2020 and included all reports published to August 2020.
T595	230-720	Sentence	denotes	The search was performed on specialized databases (PubMed and Scopus) using different combinations of HCQ and the following keywords: history, discovery, ethnomedical, synthesis, chemical structure, SAR, RAS, biological activity, approved biological activities, antiviral, antiviral mechanism, COVID-19, Q fever, Whipple’s disease, synergistic effects, synergic effects, toxicological effects, toxic effects, toxicity, animal model and antiviral activity, clinical study, preclinical study.
T596	721-828	Sentence	denotes	We did not request full-text to investigators if not available and we did not try to find unpublished data.