PMC:7696151 / 77847-78501 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
2289	292-296	Species	denotes	mice	Tax:10090
2290	335-338	Chemical	denotes	HCQ	MESH:D006886
2291	388-403	Chemical	denotes	3-bromopyruvate	MESH:C017092
2292	181-187	Disease	denotes	cancer	MESH:D009369
2293	267-283	Disease	denotes	ascites hepatoma	MESH:D001201
2294	438-443	Disease	denotes	tumor	MESH:D009369
2295	595-601	Disease	denotes	cancer	MESH:D009369

Id	Subject	Object	Predicate	Lexical cue	hp_id
T169	181-187	Phenotype	denotes	cancer	http://purl.obolibrary.org/obo/HP_0002664
T170	267-274	Phenotype	denotes	ascites	http://purl.obolibrary.org/obo/HP_0001541
T171	438-443	Phenotype	denotes	tumor	http://purl.obolibrary.org/obo/HP_0002664
T172	595-601	Phenotype	denotes	cancer	http://purl.obolibrary.org/obo/HP_0002664

Id	Subject	Object	Predicate	Lexical cue
T499	0-102	Sentence	denotes	Together with autophagy, glycolysis plays a pivotal role in satisfying the increased energetic demand.
T500	103-194	Sentence	denotes	The dual targeting of the processes may provide a new therapeutic approach in cancer cells.
T501	195-462	Sentence	denotes	Emonet, et al. [150] performed a randomized preclinical study on Earlic ascites hepatoma-bearing mice, showing that the coadministration of HCQ (60 mg/kg i.p.) and the antiglycolytic inhibitor 3-bromopyruvate possessed a synergistic effect on tumor growth inhibition.
T502	463-654	Sentence	denotes	Moreover, this treatment is associated with an improvement of oxidative status in hepatic tissue, with a decrement in the number of cancer cells, without affecting the total cell count [151].