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PMC:7696151 / 75834-77846 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2242 822-839 Gene denotes estrogen receptor Gene:2099
2243 55-60 Species denotes human Tax:9606
2244 991-995 Species denotes mice Tax:10090
2245 1082-1086 Species denotes mice Tax:10090
2246 121-124 Chemical denotes HCQ MESH:D006886
2247 385-388 Chemical denotes HCQ MESH:D006886
2248 422-432 Chemical denotes Epirubicin MESH:D015251
2249 652-655 Chemical denotes HCQ MESH:D006886
2250 903-912 Chemical denotes tamoxifen MESH:D013629
2251 975-978 Chemical denotes HCQ MESH:D006886
2252 1008-1013 Chemical denotes water MESH:D014867
2253 1062-1071 Chemical denotes tamoxifen MESH:D013629
2254 1127-1130 Chemical denotes HCQ MESH:D006886
2255 1244-1247 Chemical denotes HCQ MESH:D006886
2256 1277-1288 Chemical denotes vemurafenib MESH:D000077484
2257 1393-1396 Chemical denotes HCQ MESH:D006886
2258 1412-1419 Chemical denotes CCI-779 MESH:C401859
2259 1596-1599 Chemical denotes HCQ MESH:D006886
2260 1839-1842 Chemical denotes HCQ MESH:D006886
2261 9-15 Disease denotes cancer MESH:D009369
2262 31-38 Disease denotes ovarian MESH:D010049
2263 61-74 Disease denotes breast cancer MESH:D001943
2264 143-148 Disease denotes tumor MESH:D009369
2265 304-310 Disease denotes cancer MESH:D009369
2266 392-398 Disease denotes cancer MESH:D009369
2267 452-465 Disease denotes breast cancer MESH:D001943
2268 609-615 Disease denotes cancer MESH:D009369
2269 744-749 Disease denotes tumor MESH:D009369
2270 849-863 Disease denotes breast cancers MESH:D001943
2271 1046-1052 Disease denotes cancer MESH:D009369
2272 1116-1125 Disease denotes carcinoma MESH:D009369
2273 1205-1210 Disease denotes tumor MESH:D009369
2274 1503-1517 Disease denotes melanoma tumor MESH:D008545
2275 1538-1543 Disease denotes tumor MESH:D009369
2276 1639-1665 Disease denotes chemoresistant lung cancer MESH:D008175
2277 1683-1689 Disease denotes cancer MESH:D009369
2278 1695-1702 Disease denotes hypoxic MESH:D000860
2279 1746-1752 Disease denotes cancer MESH:D009369
2280 1905-1910 Disease denotes tumor MESH:D009369
2281 2000-2005 Disease denotes tumor MESH:D009369

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T149 9-15 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T150 61-74 Phenotype denotes breast cancer http://purl.obolibrary.org/obo/HP_0003002
T151 143-148 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T152 304-310 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T153 392-398 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T154 452-465 Phenotype denotes breast cancer http://purl.obolibrary.org/obo/HP_0003002
T155 609-615 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T156 744-749 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T157 849-863 Phenotype denotes breast cancers http://purl.obolibrary.org/obo/HP_0003002
T158 1046-1052 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T159 1116-1125 Phenotype denotes carcinoma http://purl.obolibrary.org/obo/HP_0030731
T160 1205-1210 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T161 1503-1511 Phenotype denotes melanoma http://purl.obolibrary.org/obo/HP_0002861
T162 1512-1517 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T163 1538-1543 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T164 1654-1665 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526
T165 1683-1689 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T166 1746-1752 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T167 1905-1910 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T168 2000-2005 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T486 0-155 Sentence denotes In other cancer types, such as ovarian, prostatic, and human breast cancer, the anticancer or pro-tumorigenic effects of HCQ are determined by tumor stage.
T487 156-326 Sentence denotes In the early stages of the disease, the inhibition of autophagy results in an inhibition of tumorigenesis, while in the advanced phase, it enhances cancer survival [145].
T488 327-421 Sentence denotes Then, it is important in assessing the contextual role of HCQ in cancer resistance mechanisms.
T489 422-528 Sentence denotes Epirubicin in triple-negative breast cancer therapy often lost efficacy, due to chemoresistance acquiring.
T490 529-630 Sentence denotes It has been shown that this cytotoxic agent induced autophagic flux, increasing cancer cell survival.
T491 631-808 Sentence denotes The combination with HCQ (120 mg/kg by i.p.), thanks to the anti-autophagic properties, significantly suppressed tumor growth by up to 50% with respect to the monotherapy [142].
T492 809-950 Sentence denotes In addition, estrogen receptor-positive breast cancers developed resistance to treatment with tamoxifen, due to the enhancement of autophagy.
T493 951-1078 Sentence denotes The coadministration of HCQ (1–2 mg/day/mice in drinking water) restored the susceptibility of cancer cells to tamoxifen [146].
T494 1079-1347 Sentence denotes In mice with thyroid gland xenograft carcinoma, HCQ (150 mg/kg/day p.o. for two weeks) did not provide significant results on tumor growth, while the combination of HCQ with the chemotherapic agent vemurafenib potentiated the anticancer properties of both drugs [147].
T495 1348-1595 Sentence denotes Similarly, the two weeks coadministration of HCQ (65 mg/kg) and CCI-779 resulted in a synergism that significantly enhanced their in vivo activity against melanoma tumor growth, in terms of tumor size, with respect to their single treatment [148].
T496 1596-1666 Sentence denotes HCQ was revealed also to be active against chemoresistant lung cancer.
T497 1667-1838 Sentence denotes In this type of cancer, the hypoxic conditions led to lesser susceptibility of cancer cells towards lymphocyte T-mediated cytolysis, thanks to the activation of autophagy.
T498 1839-2012 Sentence denotes HCQ intake, at doses of 30 mg/kg/day i.p. for 10 days, sensitized tumor cells to lysis and allowed, together with conventional treatment, the eradication of the tumor [149].