PMC:7696151 / 69991-70330 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
2028	283-288	Gene	denotes	IFN-α	Gene:111654
2030	30-36	Species	denotes	murine	Tax:10090
2037	64-67	Chemical	denotes	HCQ	MESH:D006886
2046	46-51	Disease	denotes	lupus	MESH:D008180
2047	320-325	Disease	denotes	lupus	MESH:D008180

Id	Subject	Object	Predicate	Lexical cue
T446	0-339	Sentence	denotes	In vivo studies on a NZB/W F1 murine model of lupus showed that HCQ in combination with PRD (2.5 mg/kg/day and 1 mg/kg/day p.o.) decreased autoantibody production, as well as being able to inhibit toll-like receptor activation, resulting in the down-regulation of type I interferon (IFN-α) which is deeply implicated in lupus pathogenesis.