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PMC:7696151 / 63004-66061 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1878 140-148 Species denotes patients Tax:9606
1879 189-192 Species denotes rat Tax:10116
1880 711-714 Species denotes rat Tax:10116
1881 1152-1156 Species denotes rats Tax:10116
1882 1307-1311 Species denotes mice Tax:10090
1883 1723-1728 Species denotes mouse Tax:10090
1884 2287-2291 Species denotes rats Tax:10116
1885 2679-2684 Species denotes mouse Tax:10090
1886 97-100 Chemical denotes HCQ MESH:D006886
1887 173-176 Chemical denotes HCQ MESH:D006886
1888 418-421 Chemical denotes HCQ MESH:D006886
1889 546-549 Chemical denotes HCQ MESH:D006886
1890 910-916 Chemical denotes lipids MESH:D008055
1891 1059-1062 Chemical denotes HCQ MESH:D006886
1892 1078-1089 Chemical denotes fatty acids MESH:D005227
1893 1091-1104 Chemical denotes triglycerides MESH:D014280
1894 1112-1123 Chemical denotes cholesterol MESH:D002784
1895 1203-1206 Chemical denotes HCQ MESH:D006886
1896 1602-1605 Chemical denotes HCQ MESH:D006886
1897 1752-1755 Chemical denotes HCQ MESH:D006886
1898 2095-2098 Chemical denotes HCQ MESH:D006886
1899 2354-2357 Chemical denotes HCQ MESH:D006886
1900 2523-2526 Chemical denotes HCQ MESH:D006886
1901 2715-2718 Chemical denotes HCQ MESH:D006886
1902 2997-3000 Chemical denotes HCQ MESH:D006886
1903 341-349 Disease denotes ischemia MESH:D007511
1904 466-493 Disease denotes ischemia-reperfusion injury MESH:D015427
1905 571-586 Disease denotes cardiac infarct MESH:D006331
1906 693-698 Disease denotes death MESH:D003643
1907 735-750 Disease denotes atherosclerotic MESH:D050197
1908 797-810 Disease denotes heart failure MESH:D006333
1909 952-967 Disease denotes atherosclerotic MESH:D050197
1910 1025-1031 Disease denotes stress MESH:D000079225
1911 1037-1057 Disease denotes platelet aggregation MESH:D001791
1912 1143-1151 Disease denotes diabetic MESH:D003920
1913 1325-1340 Disease denotes atherosclerotic MESH:D050197
1914 1532-1562 Disease denotes gastrointestinal inflammations MESH:D005767
1915 1574-1600 Disease denotes inflammatory bowel disease MESH:D015212
1916 1739-1746 Disease denotes colitis MESH:D003092
1917 1974-1986 Disease denotes Inflammation MESH:D007249
1918 2056-2078 Disease denotes pulmonary hypertension MESH:D006976
1919 2259-2282 Disease denotes ventricular hypertrophy MESH:D002312
1920 2297-2319 Disease denotes pulmonary hypertension MESH:D006976
1921 2390-2403 Disease denotes endometriosis MESH:D004715
1922 2695-2708 Disease denotes endometriosis MESH:D004715
1923 2860-2885 Disease denotes impairment of the disease MESH:D060825

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T113 797-810 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T114 1532-1562 Phenotype denotes gastrointestinal inflammations http://purl.obolibrary.org/obo/HP_0004386
T115 1574-1600 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T116 1739-1746 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583
T117 2066-2078 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T118 2259-2282 Phenotype denotes ventricular hypertrophy http://purl.obolibrary.org/obo/HP_0001714
T119 2307-2319 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T120 2390-2403 Phenotype denotes endometriosis http://purl.obolibrary.org/obo/HP_0030127
T121 2695-2708 Phenotype denotes endometriosis http://purl.obolibrary.org/obo/HP_0030127

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T403 0-149 Sentence denotes Regarding the cardioprotective effect, this review has already focused on the positive impact of HCQ on cardiovascular issues in autoimmune patients.
T404 150-376 Sentence denotes A protective effect of HCQ on neonatal rat cardiomyocytes was proven by Bourke, McCormick, Taylor, Pericleous, Blanchet, Costedoat-Chalumeau, Stuckey, Lythgoe, Stephanou and Ioannou [112] in ischemia-reperfusion animal models.
T405 377-494 Sentence denotes The pharmacological preconditioning with HCQ seems to be a good strategy to protect from ischemia-reperfusion injury.
T406 495-599 Sentence denotes The pretreatment with daily gavage of 200 mg/kg of HCQ, indeed, reduced the cardiac infarct size by 47%.
T407 600-730 Sentence denotes The mechanism underlying this effect is linked to the inhibition of apoptosis and total cell death in neonatal rat cardiomyocytes.
T408 731-811 Sentence denotes The atherosclerotic process contributes to increasing the risk of heart failure.
T409 812-862 Sentence denotes The etiology of this condition is still not clear.
T410 863-1058 Sentence denotes A hypothesis supposes that the accumulation of lipids in vessels caused the formation of atherosclerotic plaques that are responsible for vessel narrowing, shear stress, and platelet aggregation.
T411 1059-1192 Sentence denotes HCQ decreased free-fatty acids, triglycerides, total cholesterol, and LDL levels in diabetic rats under doses of 200 mg/kg/day [106].
T412 1193-1387 Sentence denotes Moreover, HCQ (10 mg/kg/day) was demonstrated to exhibit functional and structural protection in 40 high-fat diet mice, by reducing atherosclerotic area by 60% with respect to the control [114].
T413 1388-1528 Sentence denotes These favorable effects at the metabolic level might be due to its anti-inflammatory power that influences many other biological activities.
T414 1529-1719 Sentence denotes In gastrointestinal inflammations, mainly in inflammatory bowel disease, HCQ suppressed pro-inflammatory cytokines and enhanced the expression of ILs involved in anti-inflammatory processes.
T415 1720-1973 Sentence denotes In mouse models of colitis, the HCQ methacryloylated form (30 mg/kg) avoided systemic absorption, accumulating in the gastrointestinal tract, where alterations in the immune homeostasis of the intestinal mucosa had a positive impact on the disease [74].
T416 1974-2079 Sentence denotes Inflammation, together with alterations in the immune system, are at the basis of pulmonary hypertension.
T417 2080-2376 Sentence denotes The ability of HCQ to interfere with the production of pro-inflammatory cytokines from monocytes and lymphocytes might underlie the observed improvements in systolic pressure and ventricular hypertrophy, in rats with pulmonary hypertension treated with 50 mg/kg/day i.p. of HCQ for 20 days [115].
T418 2377-2540 Sentence denotes Likewise, in endometriosis, the abnormal presence of endometrium in other organs leads to a chronic inflammatory status that could be affected by HCQ intervention.
T419 2541-2735 Sentence denotes Ruiz, Rockfield, Taran, Haller, Engelman, Flores, Panina-Bordignon and Nanjundan [116] observed an increment of peritoneal macrophages in mouse models of endometriosis under HCQ (60 mg/kg i.p.).
T420 2736-2886 Sentence denotes In their role of scavengers, abnormalities in these cell populations may lead to an accumulation of endometrial cells, with impairment of the disease.
T421 2887-3057 Sentence denotes Moreover, histopathologic improvement of lesions was observed, probably due to the inhibition of autophagy by HCQ that alters anoikis response of endometrial cells [116].