PMC:7696151 / 61845-63003 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
1813	459-463	Species	denotes	mice	Tax:10090
1814	40-43	Chemical	denotes	HCQ	MESH:D006886
1815	270-273	Chemical	denotes	HCQ	MESH:D006886
1816	477-489	Chemical	denotes	azoxymethane	MESH:D001397
1817	494-516	Chemical	denotes	dextran sodium sulfate
1818	600-603	Chemical	denotes	HCQ	MESH:D006886
1819	757-760	Chemical	denotes	HCQ	MESH:D006886
1820	972-975	Chemical	denotes	ROS	MESH:D017382
1821	1049-1052	Chemical	denotes	HCQ	MESH:D006886
1822	52-64	Disease	denotes	inflammation	MESH:D007249
1823	146-152	Disease	denotes	cancer	MESH:D009369
1824	164-195	Disease	denotes	Chronic intestinal inflammation	MESH:D007249
1825	223-259	Disease	denotes	colitis-associated colorectal cancer	MESH:D015179
1826	309-315	Disease	denotes	cancer	MESH:D009369
1827	424-429	Disease	denotes	tumor	MESH:D009369
1828	527-533	Disease	denotes	cancer	MESH:D009369
1829	723-728	Disease	denotes	tumor	MESH:D009369
1830	887-892	Disease	denotes	tumor	MESH:D009369
1831	917-929	Disease	denotes	inflammation	MESH:D007249

Id	Subject	Object	Predicate	Lexical cue	hp_id
T105	146-152	Phenotype	denotes	cancer	http://purl.obolibrary.org/obo/HP_0002664
T106	223-230	Phenotype	denotes	colitis	http://purl.obolibrary.org/obo/HP_0002583
T107	253-259	Phenotype	denotes	cancer	http://purl.obolibrary.org/obo/HP_0002664
T108	309-315	Phenotype	denotes	cancer	http://purl.obolibrary.org/obo/HP_0002664
T109	424-429	Phenotype	denotes	tumor	http://purl.obolibrary.org/obo/HP_0002664
T110	527-533	Phenotype	denotes	cancer	http://purl.obolibrary.org/obo/HP_0002664
T111	723-728	Phenotype	denotes	tumor	http://purl.obolibrary.org/obo/HP_0002664
T112	887-892	Phenotype	denotes	tumor	http://purl.obolibrary.org/obo/HP_0002664

Id	Subject	Object	Predicate	Lexical cue
T397	0-163	Sentence	denotes	Given the well-recognized properties of HCQ against inflammation, it is easily intuitable that this agent could possess interesting insights into cancer treatment.
T398	164-260	Sentence	denotes	Chronic intestinal inflammation predisposes to the risk of colitis-associated colorectal cancer.
T399	261-534	Sentence	denotes	In vivo, HCQ was demonstrated to interfere with cancer growth at different stages of development, both preventing tumorigenesis in the early phases and inhibiting tumor growth in the late phases in mice treated with azoxymethane and dextran sodium sulfate to induce cancer.
T400	535-729	Sentence	denotes	In terms of animal survival, 120 days treatment with 50 mg/kg of HCQ intraperitoneal injection (i.p.) almost restored the survival rate to pre-treatment values and reduced the size of the tumor.
T401	730-1008	Sentence	denotes	The therapeutic effects of HCQ may be attributed to the significant inhibition of pro-tumorigenic and pro-inflammatory cytokines, which not only limited the tumor progression by reducing inflammation of lamina propria, but also decreased the ROS production in macrophages [111].
T402	1009-1158	Sentence	denotes	Many others are the mechanisms by which HCQ exerts anticancer effects, mainly in synergism with conventional chemotherapic drugs, as discussed later.