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PMC:7696151 / 61783-66061 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1791 15-21 Disease denotes Cancer MESH:D009369
1792 23-35 Disease denotes Inflammation MESH:D007249
1793 37-60 Disease denotes Cardiovascular Diseases MESH:D002318
1813 521-525 Species denotes mice Tax:10090
1814 102-105 Chemical denotes HCQ MESH:D006886
1815 332-335 Chemical denotes HCQ MESH:D006886
1816 539-551 Chemical denotes azoxymethane MESH:D001397
1817 556-578 Chemical denotes dextran sodium sulfate
1818 662-665 Chemical denotes HCQ MESH:D006886
1819 819-822 Chemical denotes HCQ MESH:D006886
1820 1034-1037 Chemical denotes ROS MESH:D017382
1821 1111-1114 Chemical denotes HCQ MESH:D006886
1822 114-126 Disease denotes inflammation MESH:D007249
1823 208-214 Disease denotes cancer MESH:D009369
1824 226-257 Disease denotes Chronic intestinal inflammation MESH:D007249
1825 285-321 Disease denotes colitis-associated colorectal cancer MESH:D015179
1826 371-377 Disease denotes cancer MESH:D009369
1827 486-491 Disease denotes tumor MESH:D009369
1828 589-595 Disease denotes cancer MESH:D009369
1829 785-790 Disease denotes tumor MESH:D009369
1830 949-954 Disease denotes tumor MESH:D009369
1831 979-991 Disease denotes inflammation MESH:D007249
1878 1361-1369 Species denotes patients Tax:9606
1879 1410-1413 Species denotes rat Tax:10116
1880 1932-1935 Species denotes rat Tax:10116
1881 2373-2377 Species denotes rats Tax:10116
1882 2528-2532 Species denotes mice Tax:10090
1883 2944-2949 Species denotes mouse Tax:10090
1884 3508-3512 Species denotes rats Tax:10116
1885 3900-3905 Species denotes mouse Tax:10090
1886 1318-1321 Chemical denotes HCQ MESH:D006886
1887 1394-1397 Chemical denotes HCQ MESH:D006886
1888 1639-1642 Chemical denotes HCQ MESH:D006886
1889 1767-1770 Chemical denotes HCQ MESH:D006886
1890 2131-2137 Chemical denotes lipids MESH:D008055
1891 2280-2283 Chemical denotes HCQ MESH:D006886
1892 2299-2310 Chemical denotes fatty acids MESH:D005227
1893 2312-2325 Chemical denotes triglycerides MESH:D014280
1894 2333-2344 Chemical denotes cholesterol MESH:D002784
1895 2424-2427 Chemical denotes HCQ MESH:D006886
1896 2823-2826 Chemical denotes HCQ MESH:D006886
1897 2973-2976 Chemical denotes HCQ MESH:D006886
1898 3316-3319 Chemical denotes HCQ MESH:D006886
1899 3575-3578 Chemical denotes HCQ MESH:D006886
1900 3744-3747 Chemical denotes HCQ MESH:D006886
1901 3936-3939 Chemical denotes HCQ MESH:D006886
1902 4218-4221 Chemical denotes HCQ MESH:D006886
1903 1562-1570 Disease denotes ischemia MESH:D007511
1904 1687-1714 Disease denotes ischemia-reperfusion injury MESH:D015427
1905 1792-1807 Disease denotes cardiac infarct MESH:D006331
1906 1914-1919 Disease denotes death MESH:D003643
1907 1956-1971 Disease denotes atherosclerotic MESH:D050197
1908 2018-2031 Disease denotes heart failure MESH:D006333
1909 2173-2188 Disease denotes atherosclerotic MESH:D050197
1910 2246-2252 Disease denotes stress MESH:D000079225
1911 2258-2278 Disease denotes platelet aggregation MESH:D001791
1912 2364-2372 Disease denotes diabetic MESH:D003920
1913 2546-2561 Disease denotes atherosclerotic MESH:D050197
1914 2753-2783 Disease denotes gastrointestinal inflammations MESH:D005767
1915 2795-2821 Disease denotes inflammatory bowel disease MESH:D015212
1916 2960-2967 Disease denotes colitis MESH:D003092
1917 3195-3207 Disease denotes Inflammation MESH:D007249
1918 3277-3299 Disease denotes pulmonary hypertension MESH:D006976
1919 3480-3503 Disease denotes ventricular hypertrophy MESH:D002312
1920 3518-3540 Disease denotes pulmonary hypertension MESH:D006976
1921 3611-3624 Disease denotes endometriosis MESH:D004715
1922 3916-3929 Disease denotes endometriosis MESH:D004715
1923 4081-4106 Disease denotes impairment of the disease MESH:D060825

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T103 15-21 Phenotype denotes Cancer http://purl.obolibrary.org/obo/HP_0002664
T104 37-60 Phenotype denotes Cardiovascular Diseases http://purl.obolibrary.org/obo/HP_0001626
T105 208-214 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T106 285-292 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583
T107 315-321 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T108 371-377 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T109 486-491 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T110 589-595 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T111 785-790 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T112 949-954 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T113 2018-2031 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T114 2753-2783 Phenotype denotes gastrointestinal inflammations http://purl.obolibrary.org/obo/HP_0004386
T115 2795-2821 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T116 2960-2967 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583
T117 3287-3299 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T118 3480-3503 Phenotype denotes ventricular hypertrophy http://purl.obolibrary.org/obo/HP_0001714
T119 3528-3540 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T120 3611-3624 Phenotype denotes endometriosis http://purl.obolibrary.org/obo/HP_0030127
T121 3916-3929 Phenotype denotes endometriosis http://purl.obolibrary.org/obo/HP_0030127

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T395 0-6 Sentence denotes 2.3.6.
T396 7-61 Sentence denotes Others (Cancer, Inflammation, Cardiovascular Diseases)
T397 62-225 Sentence denotes Given the well-recognized properties of HCQ against inflammation, it is easily intuitable that this agent could possess interesting insights into cancer treatment.
T398 226-322 Sentence denotes Chronic intestinal inflammation predisposes to the risk of colitis-associated colorectal cancer.
T399 323-596 Sentence denotes In vivo, HCQ was demonstrated to interfere with cancer growth at different stages of development, both preventing tumorigenesis in the early phases and inhibiting tumor growth in the late phases in mice treated with azoxymethane and dextran sodium sulfate to induce cancer.
T400 597-791 Sentence denotes In terms of animal survival, 120 days treatment with 50 mg/kg of HCQ intraperitoneal injection (i.p.) almost restored the survival rate to pre-treatment values and reduced the size of the tumor.
T401 792-1070 Sentence denotes The therapeutic effects of HCQ may be attributed to the significant inhibition of pro-tumorigenic and pro-inflammatory cytokines, which not only limited the tumor progression by reducing inflammation of lamina propria, but also decreased the ROS production in macrophages [111].
T402 1071-1220 Sentence denotes Many others are the mechanisms by which HCQ exerts anticancer effects, mainly in synergism with conventional chemotherapic drugs, as discussed later.
T403 1221-1370 Sentence denotes Regarding the cardioprotective effect, this review has already focused on the positive impact of HCQ on cardiovascular issues in autoimmune patients.
T404 1371-1597 Sentence denotes A protective effect of HCQ on neonatal rat cardiomyocytes was proven by Bourke, McCormick, Taylor, Pericleous, Blanchet, Costedoat-Chalumeau, Stuckey, Lythgoe, Stephanou and Ioannou [112] in ischemia-reperfusion animal models.
T405 1598-1715 Sentence denotes The pharmacological preconditioning with HCQ seems to be a good strategy to protect from ischemia-reperfusion injury.
T406 1716-1820 Sentence denotes The pretreatment with daily gavage of 200 mg/kg of HCQ, indeed, reduced the cardiac infarct size by 47%.
T407 1821-1951 Sentence denotes The mechanism underlying this effect is linked to the inhibition of apoptosis and total cell death in neonatal rat cardiomyocytes.
T408 1952-2032 Sentence denotes The atherosclerotic process contributes to increasing the risk of heart failure.
T409 2033-2083 Sentence denotes The etiology of this condition is still not clear.
T410 2084-2279 Sentence denotes A hypothesis supposes that the accumulation of lipids in vessels caused the formation of atherosclerotic plaques that are responsible for vessel narrowing, shear stress, and platelet aggregation.
T411 2280-2413 Sentence denotes HCQ decreased free-fatty acids, triglycerides, total cholesterol, and LDL levels in diabetic rats under doses of 200 mg/kg/day [106].
T412 2414-2608 Sentence denotes Moreover, HCQ (10 mg/kg/day) was demonstrated to exhibit functional and structural protection in 40 high-fat diet mice, by reducing atherosclerotic area by 60% with respect to the control [114].
T413 2609-2749 Sentence denotes These favorable effects at the metabolic level might be due to its anti-inflammatory power that influences many other biological activities.
T414 2750-2940 Sentence denotes In gastrointestinal inflammations, mainly in inflammatory bowel disease, HCQ suppressed pro-inflammatory cytokines and enhanced the expression of ILs involved in anti-inflammatory processes.
T415 2941-3194 Sentence denotes In mouse models of colitis, the HCQ methacryloylated form (30 mg/kg) avoided systemic absorption, accumulating in the gastrointestinal tract, where alterations in the immune homeostasis of the intestinal mucosa had a positive impact on the disease [74].
T416 3195-3300 Sentence denotes Inflammation, together with alterations in the immune system, are at the basis of pulmonary hypertension.
T417 3301-3597 Sentence denotes The ability of HCQ to interfere with the production of pro-inflammatory cytokines from monocytes and lymphocytes might underlie the observed improvements in systolic pressure and ventricular hypertrophy, in rats with pulmonary hypertension treated with 50 mg/kg/day i.p. of HCQ for 20 days [115].
T418 3598-3761 Sentence denotes Likewise, in endometriosis, the abnormal presence of endometrium in other organs leads to a chronic inflammatory status that could be affected by HCQ intervention.
T419 3762-3956 Sentence denotes Ruiz, Rockfield, Taran, Haller, Engelman, Flores, Panina-Bordignon and Nanjundan [116] observed an increment of peritoneal macrophages in mouse models of endometriosis under HCQ (60 mg/kg i.p.).
T420 3957-4107 Sentence denotes In their role of scavengers, abnormalities in these cell populations may lead to an accumulation of endometrial cells, with impairment of the disease.
T421 4108-4278 Sentence denotes Moreover, histopathologic improvement of lesions was observed, probably due to the inhibition of autophagy by HCQ that alters anoikis response of endometrial cells [116].