PMC:7696151 / 5960-6862 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
162	577-580	Species	denotes	HIV	Tax:12721
163	406-409	Chemical	denotes	HCQ	MESH:D006886
164	489-492	Chemical	denotes	HCQ	MESH:D006886
165	460-468	Disease	denotes	COVID-19	MESH:C000657245
166	565-575	Disease	denotes	infections	MESH:D007239
167	585-593	Disease	denotes	COVID-19	MESH:C000657245

Id	Subject	Object	Predicate	Lexical cue
T51	0-127	Sentence	denotes	In our review, the articles included were also analyzed in relation to the year of publication and the experimental model used.
T52	128-229	Sentence	denotes	Regarding the chronology of the publications, most of the articles were published in the last decade.
T53	230-488	Sentence	denotes	The high peaks correspond to the proportional number of papers on antiviral activity in 2020; this result is consistent with the actual increasing interest towards the role of HCQ as a possible therapeutic strategy in the current COVID-19 sanitary emergency.
T54	489-576	Sentence	denotes	HCQ alone, or in combination with other drugs, was used in various types of infections.
T55	577-656	Sentence	denotes	HIV and COVID-19 were the most cited, with 10 and 7 reports each, respectively.
T56	657-734	Sentence	denotes	Our systematic review included 49 preclinical studies and 84 clinical trials.
T57	735-819	Sentence	denotes	The considered in vivo studies were carried out using allograft or xenograft models.
T58	820-902	Sentence	denotes	The most important outcomes of the review are graphically illustrated in Figure 3.