> top > docs > PMC:7696151 > spans > 5161-7082 > annotations

PMC:7696151 / 5161-7082 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
162 1376-1379 Species denotes HIV Tax:12721
163 1205-1208 Chemical denotes HCQ MESH:D006886
164 1288-1291 Chemical denotes HCQ MESH:D006886
165 1259-1267 Disease denotes COVID-19 MESH:C000657245
166 1364-1374 Disease denotes infections MESH:D007239
167 1384-1392 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T42 0-4 Sentence denotes 2.1.
T43 5-19 Sentence denotes Study Analysis
T44 20-120 Sentence denotes The initial survey of the literature identified 2756 reports (2066 from Scopus and 690 from PubMed).
T45 121-255 Sentence denotes Then, 293 the duplicates between the two databases were eliminated and were considered only one at a time, resulting in 2463 articles.
T46 256-412 Sentence denotes After the primary screening based on titles and abstracts, 959 manuscripts were excluded since they did not fulfil the inclusion criteria or were off-topic.
T47 413-497 Sentence denotes Finally, 1504 articles were thoroughly analyzed and among these, 1442 were excluded.
T48 498-662 Sentence denotes The analysis of the reference lists from some selected items led to the inclusion of an extra 71 appropriate articles, after titles, abstracts, and full-text study.
T49 663-718 Sentence denotes In total, 133 papers were selected for data extraction.
T50 719-798 Sentence denotes A flowchart illustrating the steps of the study selection is shown in Figure 2.
T51 799-926 Sentence denotes In our review, the articles included were also analyzed in relation to the year of publication and the experimental model used.
T52 927-1028 Sentence denotes Regarding the chronology of the publications, most of the articles were published in the last decade.
T53 1029-1287 Sentence denotes The high peaks correspond to the proportional number of papers on antiviral activity in 2020; this result is consistent with the actual increasing interest towards the role of HCQ as a possible therapeutic strategy in the current COVID-19 sanitary emergency.
T54 1288-1375 Sentence denotes HCQ alone, or in combination with other drugs, was used in various types of infections.
T55 1376-1455 Sentence denotes HIV and COVID-19 were the most cited, with 10 and 7 reports each, respectively.
T56 1456-1533 Sentence denotes Our systematic review included 49 preclinical studies and 84 clinical trials.
T57 1534-1618 Sentence denotes The considered in vivo studies were carried out using allograft or xenograft models.
T58 1619-1701 Sentence denotes The most important outcomes of the review are graphically illustrated in Figure 3.
T59 1702-1850 Sentence denotes The assessment of bias risk based on a checklist adapted from the Cochrane Handbook for Systematic Reviews of Interventions is reported in Figure 4.
T60 1851-1921 Sentence denotes The number of high-risk reports is due to the case reports considered.