PMC:7696151 / 42941-44012 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
1216	434-439	Species	denotes	women	Tax:9606
1217	830-834	Species	denotes	rats	Tax:10116
1218	480-483	Chemical	denotes	HCQ	MESH:D006886
1219	792-795	Chemical	denotes	HCQ	MESH:D006886
1220	0-20	Disease	denotes	Rheumatoid arthritis	MESH:D001172
1221	35-53	Disease	denotes	autoimmune disease	MESH:D001327
1222	80-92	Disease	denotes	inflammation	MESH:D007249
1223	170-190	Disease	denotes	rheumatoid arthritis	MESH:D001172
1224	249-259	Disease	denotes	rheumatoid	MESH:D011695
1225	389-409	Disease	denotes	rheumatoid arthritis	MESH:D001172
1226	537-550	Disease	denotes	hyperactivity	MESH:D006948
1227	674-683	Disease	denotes	Jancinova
1228	849-858	Disease	denotes	arthritis	MESH:D001168
1229	1053-1065	Disease	denotes	inflammation	MESH:D007249

Id	Subject	Object	Predicate	Lexical cue	hp_id
T61	0-20	Phenotype	denotes	Rheumatoid arthritis	http://purl.obolibrary.org/obo/HP_0001370
T62	35-53	Phenotype	denotes	autoimmune disease	http://purl.obolibrary.org/obo/HP_0002960
T63	119-139	Phenotype	denotes	Immune dysregulation	http://purl.obolibrary.org/obo/HP_0002958
T64	170-190	Phenotype	denotes	rheumatoid arthritis	http://purl.obolibrary.org/obo/HP_0001370
T65	389-409	Phenotype	denotes	rheumatoid arthritis	http://purl.obolibrary.org/obo/HP_0001370
T66	537-550	Phenotype	denotes	hyperactivity	http://purl.obolibrary.org/obo/HP_0000752
T67	849-858	Phenotype	denotes	arthritis	http://purl.obolibrary.org/obo/HP_0001369

Id	Subject	Object	Predicate	Lexical cue
T280	0-118	Sentence	denotes	Rheumatoid arthritis is a systemic autoimmune disease, characterized by chronic inflammation and damage to the joints.
T281	119-349	Sentence	denotes	Immune dysregulation underlies the pathogenesis of rheumatoid arthritis, leading to uncontrolled production of antibodies, mainly rheumatoid factor and citrullinate, involved in the autoreactivity against cartilage and bone [117].
T282	350-446	Sentence	denotes	It is estimated that the prevalence of rheumatoid arthritis is around 1%, mainly in women [118].
T283	447-622	Sentence	denotes	The immunosuppressive effects of HCQ are due to the ability to modulate T-cell and B-cell hyperactivity, resulting in a reduction of pro-inflammatory cytokine gene expression.
T284	623-859	Sentence	denotes	As the involvement of neutrophils in this disease, Jancinova, Pazourekova, Lucova, Perecko, Mihalova, Bauerova, Nosal and Drabikova [75] investigated the impact of oral HCQ administration on these cells, in rats with adjuvant arthritis.
T285	860-1071	Sentence	denotes	At doses of 40 mg/kg daily, per oral administration (p.o.), it strongly decreased the blood concentration of neutrophil-derived oxidants, involved in the tissue damage and the onset of chronic inflammation [75].