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PMC:7696151 / 42913-47447 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1201 7-27 Disease denotes Rheumatoid Arthritis MESH:D001172
1216 462-467 Species denotes women Tax:9606
1217 858-862 Species denotes rats Tax:10116
1218 508-511 Chemical denotes HCQ MESH:D006886
1219 820-823 Chemical denotes HCQ MESH:D006886
1220 28-48 Disease denotes Rheumatoid arthritis MESH:D001172
1221 63-81 Disease denotes autoimmune disease MESH:D001327
1222 108-120 Disease denotes inflammation MESH:D007249
1223 198-218 Disease denotes rheumatoid arthritis MESH:D001172
1224 277-287 Disease denotes rheumatoid MESH:D011695
1225 417-437 Disease denotes rheumatoid arthritis MESH:D001172
1226 565-578 Disease denotes hyperactivity MESH:D006948
1227 702-711 Disease denotes Jancinova
1228 877-886 Disease denotes arthritis MESH:D001168
1229 1081-1093 Disease denotes inflammation MESH:D007249
1246 1274-1282 Species denotes patients Tax:9606
1247 1724-1732 Species denotes patients Tax:9606
1248 1933-1941 Species denotes patients Tax:9606
1249 2329-2337 Species denotes patients Tax:9606
1250 1211-1214 Chemical denotes HCQ MESH:D006886
1251 1348-1351 Chemical denotes HCQ MESH:D006886
1252 1512-1515 Chemical denotes HCQ MESH:D006886
1253 1744-1757 Chemical denotes sulfasalazine MESH:D012460
1254 1762-1765 Chemical denotes HCQ MESH:D006886
1255 1789-1792 Chemical denotes HCQ MESH:D006886
1256 1869-1882 Chemical denotes sulfasalazine MESH:D012460
1257 1955-1958 Chemical denotes HCQ MESH:D006886
1258 1288-1308 Disease denotes rheumatoid arthritis MESH:D001172
1259 1426-1435 Disease denotes synovitis MESH:D013585
1260 1440-1450 Disease denotes joint pain MESH:D018771
1261 2110-2114 Disease denotes pain MESH:D010146
1303 2662-2666 Gene denotes IL-6 Gene:3569
1304 2820-2826 Gene denotes leptin Gene:3952
1305 2953-2957 Gene denotes IL-6 Gene:3569
1306 2962-2968 Gene denotes leptin Gene:3952
1307 4131-4138 Gene denotes insulin Gene:3630
1308 4198-4205 Gene denotes insulin Gene:3630
1309 2347-2355 Species denotes patients Tax:9606
1310 3170-3178 Species denotes patients Tax:9606
1311 3533-3541 Species denotes patients Tax:9606
1312 3699-3704 Species denotes women Tax:9606
1313 3801-3806 Species denotes women Tax:9606
1314 4095-4103 Species denotes patients Tax:9606
1315 4471-4479 Species denotes patients Tax:9606
1316 2690-2695 Chemical denotes lipid MESH:D008055
1317 2929-2932 Chemical denotes HCQ MESH:D006886
1318 3000-3003 Chemical denotes HCQ MESH:D006886
1319 3213-3224 Chemical denotes cholesterol MESH:D002784
1320 3277-3289 Chemical denotes triglyceride MESH:D014280
1321 3315-3318 Chemical denotes HCQ MESH:D006886
1322 3403-3414 Chemical denotes cholesterol MESH:D002784
1323 3429-3432 Chemical denotes HCQ MESH:D006886
1324 3598-3601 Chemical denotes HCQ MESH:D006886
1325 3759-3762 Chemical denotes HCQ MESH:D006886
1326 3790-3797 Chemical denotes glucose MESH:D005947
1327 4064-4067 Chemical denotes HCQ MESH:D006886
1328 4440-4443 Chemical denotes HCQ MESH:D006886
1329 2361-2381 Disease denotes rheumatoid arthritis MESH:D001172
1330 2528-2543 Disease denotes atherosclerotic MESH:D050197
1331 2593-2605 Disease denotes hypertension MESH:D006973
1332 2607-2614 Disease denotes obesity MESH:D009765
1333 2620-2638 Disease denotes metabolic syndrome MESH:D024821
1334 2765-2777 Disease denotes inflammation MESH:D007249
1335 3007-3019 Disease denotes dyslipidemia MESH:D050171
1336 3139-3159 Disease denotes rheumatoid arthritis MESH:D001172
1337 3547-3567 Disease denotes rheumatoid arthritis MESH:D001172
1338 3710-3730 Disease denotes rheumatoid arthritis MESH:D001172
1339 3985-3993 Disease denotes diabetic MESH:D003920
1340 4015-4035 Disease denotes rheumatoid arthritis MESH:D001172
1341 4285-4303 Disease denotes insulin metabolism MESH:D008659
1342 4417-4425 Disease denotes diabetic MESH:D003920
1343 4488-4497 Disease denotes arthritis MESH:D001168

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T60 7-27 Phenotype denotes Rheumatoid Arthritis http://purl.obolibrary.org/obo/HP_0001370
T61 28-48 Phenotype denotes Rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T62 63-81 Phenotype denotes autoimmune disease http://purl.obolibrary.org/obo/HP_0002960
T63 147-167 Phenotype denotes Immune dysregulation http://purl.obolibrary.org/obo/HP_0002958
T64 198-218 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T65 417-437 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T66 565-578 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T67 877-886 Phenotype denotes arthritis http://purl.obolibrary.org/obo/HP_0001369
T68 1288-1308 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T69 1426-1435 Phenotype denotes synovitis http://purl.obolibrary.org/obo/HP_0100769
T70 1440-1450 Phenotype denotes joint pain http://purl.obolibrary.org/obo/HP_0002829
T71 2110-2114 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T72 2361-2381 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T73 2593-2605 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T74 2607-2614 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T75 3007-3019 Phenotype denotes dyslipidemia http://purl.obolibrary.org/obo/HP_0003119
T76 3139-3159 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T77 3547-3567 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T78 3710-3730 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T79 4015-4035 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T80 4131-4149 Phenotype denotes insulin resistance http://purl.obolibrary.org/obo/HP_0000855
T81 4488-4497 Phenotype denotes arthritis http://purl.obolibrary.org/obo/HP_0001369

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T278 0-6 Sentence denotes 2.3.1.
T279 7-27 Sentence denotes Rheumatoid Arthritis
T280 28-146 Sentence denotes Rheumatoid arthritis is a systemic autoimmune disease, characterized by chronic inflammation and damage to the joints.
T281 147-377 Sentence denotes Immune dysregulation underlies the pathogenesis of rheumatoid arthritis, leading to uncontrolled production of antibodies, mainly rheumatoid factor and citrullinate, involved in the autoreactivity against cartilage and bone [117].
T282 378-474 Sentence denotes It is estimated that the prevalence of rheumatoid arthritis is around 1%, mainly in women [118].
T283 475-650 Sentence denotes The immunosuppressive effects of HCQ are due to the ability to modulate T-cell and B-cell hyperactivity, resulting in a reduction of pro-inflammatory cytokine gene expression.
T284 651-887 Sentence denotes As the involvement of neutrophils in this disease, Jancinova, Pazourekova, Lucova, Perecko, Mihalova, Bauerova, Nosal and Drabikova [75] investigated the impact of oral HCQ administration on these cells, in rats with adjuvant arthritis.
T285 888-1099 Sentence denotes At doses of 40 mg/kg daily, per oral administration (p.o.), it strongly decreased the blood concentration of neutrophil-derived oxidants, involved in the tissue damage and the onset of chronic inflammation [75].
T286 1100-1309 Sentence denotes A 36-week randomized, double-blind, placebo-controlled trial has evaluated the effect of the administration of HCQ in a dose of up to 7 mg/kg per day (maximum 400 mg/day) in patients with rheumatoid arthritis.
T287 1310-1501 Sentence denotes Within 36 weeks and during the study, HCQ showed statistically significant benefits on physical function, mainly on synovitis and joint pain, without side effects with respect to the control.
T288 1502-1577 Sentence denotes Moreover, HCQ was associated with a decrement of corticosteroid injections.
T289 1578-1661 Sentence denotes By contrast, no improvements in psychological function have been demonstrated [76].
T290 1662-1912 Sentence denotes Two comparative double-blind, randomized trials, involving 60 patients each, with sulfasalazine and HCQ have demonstrated that HCQ showed no significant differences among overall clinical effects respect to sulfasalazine, but presented a later onset.
T291 1913-2343 Sentence denotes In the first study, patients treated with HCQ (400 mg/day for 6 months and 200 mg/day for the next 6 months) experienced time-dependent statistically significant improvements in morning stiffness, pain, swollen joints, together with a decrease in blood levels of immunoglobulin M and erythrocyte sedimentation rate [77], while, in the second study, the same treatment was associated to no erosions in the 12% of the patients [78].
T292 2344-2464 Sentence denotes In patients with rheumatoid arthritis, the cardiovascular risk is more than doubled, compared to the healthy population.
T293 2465-2639 Sentence denotes Chronic inflammatory status leads to an intensification of the atherosclerotic process, resulting in a higher susceptibility to hypertension, obesity, and metabolic syndrome.
T294 2640-2760 Sentence denotes The overproduction of IL-6 is strictly related to lipid profile alterations, given its role in adipose tissue lipolysis.
T295 2761-2838 Sentence denotes The inflammation and endothelial damage are exacerbated by leptin production.
T296 2839-2976 Sentence denotes Batun-Garrido, Salas-Magana and Juarez-Rojop [79] found a significant correlation between HCQ treatment and lower IL-6 and leptin levels.
T297 2977-3342 Sentence denotes The positive effect of HCQ on dyslipidemia was also confirmed by Morris, Wasko, Antohe, Sartorius, Kirchner, Dancea and Bili [80] in a cohort study involving 706 rheumatoid arthritis diagnosed patients, finding a significant and stable cholesterol-lowering, mainly Low-Density Lipoprotein (LDL), and triglyceride decrease associated with HCQ intake (6.5 mg/kg/day).
T298 3343-3573 Sentence denotes A small but statistically significant amelioration in total cholesterol and LDL under HCQ treatment at the same dosage was also highlighted by a randomized, double-blind cross-over trial on patients with rheumatoid arthritis [81].
T299 3574-3731 Sentence denotes The correlation between HCQ and cardiovascular risk was also assessed in a cross-sectional observational study involving 177 women with rheumatoid arthritis.
T300 3732-3868 Sentence denotes At doses of 200 mg/kg/day, HCQ usage led to lower fasting glucose in women, arising as a valuable tool to enhance glycemic control [82].
T301 3869-4084 Sentence denotes However, apparent different outcomes were derived from a randomized double-blind crossover trial, recruiting 23 non-diabetic subjects with stable rheumatoid arthritis to receive 6.5 mg/kg/day of HCQ for eight weeks.
T302 4085-4171 Sentence denotes For these patients, no significant changes in insulin resistance were observable [81].
T303 4172-4304 Sentence denotes This study evaluated only insulin sensitivity, by Homeostatic Model Assessment (HOMA) index, without considering insulin metabolism.
T304 4305-4407 Sentence denotes Thus, inconsistency should be explained by this factor, together with the short duration of treatment.
T305 4408-4534 Sentence denotes The anti-diabetic properties of HCQ have been also assessed in patients without arthritis, as reported in the next paragraphs.