PMC:7696151 / 4109-4397 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"116","span":{"begin":63,"end":91},"obj":"Chemical"},{"id":"118","span":{"begin":104,"end":112},"obj":"Disease"}],"attributes":[{"id":"A118","pred":"tao:has_database_id","subj":"118","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" have demonstrated that the halogen substitutions of different 4-aminoquinolinesderivatives reduced the toxicity, but it also reduced the pharmacological activity. Instead, the therapeutic ratio is decreased by substitution of the alkyl side chain with an aryl chain. Nevertheless, the th"}

{"project":"LitCovid-sentences","denotations":[{"id":"T34","span":{"begin":164,"end":267},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" have demonstrated that the halogen substitutions of different 4-aminoquinolinesderivatives reduced the toxicity, but it also reduced the pharmacological activity. Instead, the therapeutic ratio is decreased by substitution of the alkyl side chain with an aryl chain. Nevertheless, the th"}