> top > docs > PMC:7696151 > spans > 4066-4517 > annotations

PMC:7696151 / 4066-4517 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
116 106-134 Chemical denotes 4-aminoquinolinesderivatives
117 436-443 Chemical denotes carbons MESH:D002244
118 147-155 Disease denotes toxicity MESH:D064420
119 361-369 Disease denotes toxicity MESH:D064420

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T33 0-206 Sentence denotes Studies of structure-activity relationships have demonstrated that the halogen substitutions of different 4-aminoquinolinesderivatives reduced the toxicity, but it also reduced the pharmacological activity.
T34 207-310 Sentence denotes Instead, the therapeutic ratio is decreased by substitution of the alkyl side chain with an aryl chain.
T35 311-451 Sentence denotes Nevertheless, the therapeutic ratio decreases and toxicity increases with an increase of the alkyl side-chain length above 5 carbons [7,10].