PMC:7696151 / 39693-40123 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1147","span":{"begin":209,"end":219},"obj":"Species"},{"id":"1153","span":{"begin":83,"end":86},"obj":"Chemical"},{"id":"1154","span":{"begin":201,"end":204},"obj":"Chemical"},{"id":"1155","span":{"begin":290,"end":293},"obj":"Chemical"}],"attributes":[{"id":"A1147","pred":"tao:has_database_id","subj":"1147","obj":"Tax:2697049"},{"id":"A1153","pred":"tao:has_database_id","subj":"1153","obj":"MESH:D006886"},{"id":"A1154","pred":"tao:has_database_id","subj":"1154","obj":"MESH:D006886"},{"id":"A1155","pred":"tao:has_database_id","subj":"1155","obj":"MESH:D006886"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"e of 200 mg administered twice daily for four days [50]. However, this recommended HCQ dosage regimen was based only on the ratio of free lung trough concentration to in vitro EC50 values (the EC50 of HCQ for SARS-CoV-2 ranged between 0.72 and 17.31µM) and did not consider the tendency of HCQ to accumulate within acidic cellular organelles like endosomes, lysosomes, and Golgi apparatus [69]. In fact, it has been demonstrated t"}

{"project":"LitCovid-sentences","denotations":[{"id":"T259","span":{"begin":57,"end":394},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"e of 200 mg administered twice daily for four days [50]. However, this recommended HCQ dosage regimen was based only on the ratio of free lung trough concentration to in vitro EC50 values (the EC50 of HCQ for SARS-CoV-2 ranged between 0.72 and 17.31µM) and did not consider the tendency of HCQ to accumulate within acidic cellular organelles like endosomes, lysosomes, and Golgi apparatus [69]. In fact, it has been demonstrated t"}