PMC:7696151 / 24924-25693 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
751	558-561	Gene	denotes	p62	Gene:23636
752	55-65	Species	denotes	Zika virus	Tax:64320
753	67-71	Species	denotes	ZIKV	Tax:64320
754	309-313	Species	denotes	ZIKV	Tax:64320
755	381-385	Species	denotes	mice	Tax:10090
756	475-479	Species	denotes	ZIKV	Tax:64320
757	612-616	Species	denotes	ZIKV	Tax:64320
758	743-751	Species	denotes	patients	Tax:9606
759	764-768	Species	denotes	ZIKV	Tax:64320
760	37-40	Chemical	denotes	HCQ	MESH:D006886
761	267-270	Chemical	denotes	HCQ	MESH:D006886
762	417-420	Chemical	denotes	HCQ	MESH:D006886
763	508-511	Chemical	denotes	HCQ	MESH:D006886
764	718-721	Chemical	denotes	HCQ	MESH:D006886
765	340-355	Disease	denotes	fetal infection	MESH:D005315
766	480-489	Disease	denotes	infection	MESH:D007239
767	617-626	Disease	denotes	infection	MESH:D007239
768	631-651	Disease	denotes	fetal growth defects	MESH:D005317
769	752-760	Disease	denotes	infected	MESH:D007239

Id	Subject	Object	Predicate	Lexical cue
T172	0-168	Sentence	denotes	Another possible antiviral effect of HCQ is exerted on Zika virus (ZIKV), an RNA virus of the Flaviviridae family transmitted by numerous mosquitoes of the genus Aedes.
T173	169-356	Sentence	denotes	No clinical studies have been conducted yet, but an in vivo study has demonstrated the ability of HCQ to attenuate vertical transmission of ZIKV by reducing placental and fetal infection.
T174	357-490	Sentence	denotes	In this study, pregnant mice were treated with 40 mg/kg/day HCQ via intraperitoneal injection beginning one day after ZIKV infection.
T175	491-657	Sentence	denotes	It was seen that HCQ acted as an autophagy inhibitor by increasing p62 levels in trophoblast and thus reducing placental ZIKV infection and fetal growth defects [31].
T176	658-769	Sentence	denotes	To date, no clinical trials have been conducted to evaluate HCQ antiviral effects in patients infected by ZIKV.