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PMC:7696151 / 23031-24923 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
698 124-132 Species denotes patients Tax:9606
699 275-292 Species denotes hepatitis C virus Tax:11103
700 452-460 Species denotes patients Tax:9606
701 477-494 Species denotes hepatitis C virus Tax:11103
702 665-673 Species denotes patients Tax:9606
703 959-967 Species denotes patients Tax:9606
704 1378-1385 Species denotes patient Tax:9606
705 1653-1660 Species denotes patient Tax:9606
706 294-297 Species denotes HCV Tax:11103
707 1581-1584 Species denotes HCV Tax:11103
708 264-267 Chemical denotes HCQ MESH:D006886
709 532-535 Chemical denotes HCQ MESH:D006886
710 541-561 Chemical denotes pegylated interferon
711 566-575 Chemical denotes ribavirin MESH:D012254
712 809-829 Chemical denotes pegylated interferon
713 860-869 Chemical denotes ribavirin MESH:D012254
714 905-908 Chemical denotes HCQ MESH:D006886
715 971-976 Chemical denotes HCQ + MESH:D006886
716 1113-1118 Chemical denotes HCQ + MESH:D006886
717 1252-1257 Chemical denotes HCQ + MESH:D006886
718 1473-1476 Chemical denotes HCQ MESH:D006886
719 1788-1796 Chemical denotes steroids MESH:D013256
720 1813-1816 Chemical denotes HCQ MESH:D006886
721 1820-1832 Chemical denotes sulfadiazine MESH:D013411
722 0-15 Disease denotes Hepatitis virus MESH:D006525
723 90-103 Disease denotes liver disease MESH:D008107
724 191-200 Disease denotes cirrhosis MESH:D005355
725 224-236 Disease denotes liver cancer MESH:D006528
726 461-469 Disease denotes infected MESH:D007239
727 631-650 Disease denotes chronic hepatitis C MESH:D019698
728 1401-1440 Disease denotes Porphyria Cutanea Tarda and Hepatitis C MESH:D017119
729 1527-1542 Disease denotes Porphyria Tarda MESH:D017119
730 1666-1708 Disease denotes chronic hepatitis and rheumatoid arthritis MESH:D001172
731 1725-1740 Disease denotes hepatitis virus MESH:D006525

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T26 0-9 Phenotype denotes Hepatitis http://purl.obolibrary.org/obo/HP_0012115
T27 90-103 Phenotype denotes liver disease http://purl.obolibrary.org/obo/HP_0001392
T28 191-200 Phenotype denotes cirrhosis http://purl.obolibrary.org/obo/HP_0001394
T29 224-236 Phenotype denotes liver cancer http://purl.obolibrary.org/obo/HP_0002896
T30 275-284 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T31 477-486 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T32 631-648 Phenotype denotes chronic hepatitis http://purl.obolibrary.org/obo/HP_0200123
T33 1429-1438 Phenotype denotes Hepatitis http://purl.obolibrary.org/obo/HP_0012115
T34 1666-1683 Phenotype denotes chronic hepatitis http://purl.obolibrary.org/obo/HP_0200123
T35 1688-1708 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T36 1725-1734 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T162 0-237 Sentence denotes Hepatitis virus, an RNA virus belonging to the Flaviviridae family, is closely related to liver disease, which in 70–80% of patients becomes chronic, resulting in major complications such as cirrhosis and, in the year, also liver cancer.
T163 238-334 Sentence denotes The antiviral activity of HCQ on the hepatitis C virus (HCV) in monotherapy has not been tested.
T164 335-417 Sentence denotes However, it seems that this drug increases the antiviral effect of standard drugs.
T165 418-660 Sentence denotes In a study including 120 Egyptian patients infected by the hepatitis C virus, it was seen that the combination of HCQ with pegylated interferon and ribavirin could improve biochemical and virological responses in chronic hepatitis C subjects.
T166 661-918 Sentence denotes All patients were randomized and divided into two groups; the control group treated with standard-of-care (SOC) consisted of 160 µg of subcutaneous pegylated interferon and 1000–12000 mg/day of oral ribavirin, and the group treated with 200 mg HCQ plus SOC.
T167 919-1095 Sentence denotes At the end of the treatment (12 weeks), patients of HCQ + SOC group showed a high virological response compared to the control group (54/60 (90%) vs. 43/60 (71.7%); p = 0.011).
T168 1096-1314 Sentence denotes Moreover, in the HCQ + SOC group, there was a normalization of ALT levels, as is also demonstrated by the earlier biochemical response (EBR) highlighted in HCQ + SOC group 58/60 (96.7%) than SOC group 42/60 (70%) [30].
T169 1315-1441 Sentence denotes These results were confirmed by several case reports regarding patient treatment with Porphyria Cutanea Tarda and Hepatitis C.
T170 1442-1634 Sentence denotes It was seen that a low dose of HCQ (100 mg twice weekly) prevented the recurrence of Porphyria Tarda and reduced the viral response during HCV therapy, including ribavirin and interferon [45].
T171 1635-1892 Sentence denotes Furthermore, in a patient with chronic hepatitis and rheumatoid arthritis, a low risk for hepatitis virus reactivation was observed after treatment with steroids (< 7.5 mg/day), HCQ or sulfadiazine [46] in combination with antivirals as prophylaxis [47,48].