PMC:7696151 / 22333-23009 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
655	360-371	Species	denotes	chikungunya	Tax:37124
656	497-500	Chemical	denotes	HCQ	MESH:D006886
657	79-94	Disease	denotes	virus infection	MESH:D001102
658	145-161	Disease	denotes	CHIKV infections	MESH:D007239
659	191-198	Disease	denotes	viremia	MESH:D014766
660	372-381	Disease	denotes	arthritis	MESH:D001168
661	517-534	Disease	denotes	viremia reduction	MESH:D007022
662	598-607	Disease	denotes	infection	MESH:D007239
663	663-675	Disease	denotes	inflammation	MESH:D007249

Id	Subject	Object	Predicate	Lexical cue	hp_id
T23	191-198	Phenotype	denotes	viremia	http://purl.obolibrary.org/obo/HP_0020071
T24	372-381	Phenotype	denotes	arthritis	http://purl.obolibrary.org/obo/HP_0001369
T25	517-524	Phenotype	denotes	viremia	http://purl.obolibrary.org/obo/HP_0020071

Id	Subject	Object	Predicate	Lexical cue
T157	0-102	Sentence	denotes	The results obtained could be explained with the different characterization of virus infection phases.
T158	103-387	Sentence	denotes	It is known that while the acute phase of CHIKV infections is due to the development of viremia, the chronic phase is closely related to an immune-mediated phenomenon, as pro-inflammatory cytokines and chemokines play important roles in the pathogenesis of chikungunya arthritis [44].
T159	388-676	Sentence	denotes	Therefore, considering the results obtained from these clinical studies, it is possible to say that although HCQ does not affect viremia reduction, as demonstrated by the lack of activity in the first phase of infection, it can improve the chronic phase diseases by reducing inflammation.