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PMC:7692688 / 52-1243 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
17 242-247 Gene denotes spike Gene:43740568
18 371-379 Gene denotes SERPINA1 Gene:5265
19 380-399 Gene denotes alpha-1 antitrypsin Gene:5265
20 0-39 Species denotes Severe acute respiratory syndrome virus Tax:694009
21 43-53 Species denotes SARS-CoV-2 Tax:2697049
22 230-241 Species denotes coronavirus Tax:11118
23 411-421 Species denotes SARS-CoV-2 Tax:2697049
24 542-552 Species denotes SARS-CoV-2 Tax:2697049
25 1095-1105 Species denotes SARS-CoV-2 Tax:2697049
26 769-779 Species denotes SARS-CoV-2 Tax:2697049
27 994-1004 Species denotes SARS-CoV-2 Tax:2697049
28 814-819 Chemical denotes Caco2
29 83-105 Disease denotes coronavirus disease 19 MESH:C000657245
30 107-115 Disease denotes COVID-19 MESH:C000657245
31 1140-1148 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-126 Sentence denotes Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current coronavirus disease 19 (COVID-19) pandemic.
T4 127-282 Sentence denotes Protease inhibitors are under consideration as virus entry inhibitors that prevent the cleavage of the coronavirus spike (S) protein by cellular proteases.
T5 283-479 Sentence denotes Herein, we showed that the protease inhibitor aprotinin (but not the protease inhibitor SERPINA1/alpha-1 antitrypsin) inhibited SARS-CoV-2 replication in therapeutically achievable concentrations.
T6 480-634 Sentence denotes An analysis of proteomics and translatome data indicated that SARS-CoV-2 replication is associated with a downregulation of host cell protease inhibitors.
T7 635-743 Sentence denotes Hence, aprotinin may compensate for downregulated host cell proteases during later virus replication cycles.
T8 744-930 Sentence denotes Aprotinin displayed anti-SARS-CoV-2 activity in different cell types (Caco2, Calu-3, and primary bronchial epithelial cell air–liquid interface cultures) and against four virus isolates.
T9 931-1014 Sentence denotes In conclusion, therapeutic aprotinin concentrations exert anti-SARS-CoV-2 activity.
T10 1015-1191 Sentence denotes An approved aprotinin aerosol may have potential for the early local control of SARS-CoV-2 replication and the prevention of COVID-19 progression to a severe, systemic disease.