PMC:7692688 / 15605-16670
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
370 | 79-86 | Gene | denotes | TMPRSS2 | Gene:7113 |
371 | 382-388 | Gene | denotes | SPINT1 | Gene:6692 |
372 | 390-422 | Gene | denotes | Kunitz-type protease inhibitor 1 | Gene:6692 |
373 | 425-431 | Gene | denotes | SPINT2 | Gene:10653 |
374 | 433-465 | Gene | denotes | Kunitz-type protease inhibitor 2 | Gene:10653 |
375 | 472-480 | Gene | denotes | SERPINA1 | Gene:5265 |
376 | 482-501 | Gene | denotes | alpha-1-antitrypsin | Gene:5265 |
377 | 706-714 | Gene | denotes | SERPINA1 | Gene:5265 |
378 | 719-725 | Gene | denotes | SPINT2 | Gene:10653 |
379 | 743-749 | Gene | denotes | SPINT1 | Gene:6692 |
380 | 167-168 | Gene | denotes | S | Gene:43740568 |
381 | 108-118 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
382 | 920-930 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
383 | 217-237 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
384 | 298-317 | Disease | denotes | SARS-CoV-2-infected | MESH:C000657245 |
385 | 534-553 | Disease | denotes | SARS-CoV-2-infected | MESH:C000657245 |
386 | 572-580 | Disease | denotes | infected | MESH:D007239 |
387 | 605-614 | Disease | denotes | infection | MESH:D007239 |
388 | 770-789 | Disease | denotes | SARS-CoV-2-infected | MESH:C000657245 |
389 | 816-836 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T133 | 0-187 | Sentence | denotes | Host cell protease inhibitors interfere with the activity of proteases such as TMPRSS2 [33,34] that mediate SARS-CoV-2 cell entry by cleaving and activating the viral S protein [9,11,12]. |
T134 | 188-627 | Sentence | denotes | An analysis of the effect of SARS-CoV-2 infection on host cell protease inhibitors using proteomics data from SARS-CoV-2-infected Caco2 cells [35] showed that the endogenous protease inhibitors SPINT1 (Kunitz-type protease inhibitor 1), SPINT2 (Kunitz-type protease inhibitor 2), and SERPINA1 (alpha-1-antitrypsin) are present at lower levels in SARS-CoV-2-infected cells than in non-infected control cells 24 h post-infection (Figure 4A). |
T135 | 628-808 | Sentence | denotes | Translatome data from the same dataset [35] indicated that the translation of SERPINA1 and SPINT2 (but not that of SPINT1) is also reduced in SARS-CoV-2-infected cells (Figure 4B). |
T136 | 809-943 | Sentence | denotes | Hence, SARS-CoV-2 infection results in the downregulation of endogenous protease inhibitors, which may support SARS-CoV-2 replication. |
T137 | 944-1065 | Sentence | denotes | Thus, compensation for downregulated endogenous protease inhibitors may contribute to the antiviral effects of aprotinin. |