> top > docs > PMC:7692688 > spans > 15605-16670 > annotations

PMC:7692688 / 15605-16670 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
370 79-86 Gene denotes TMPRSS2 Gene:7113
371 382-388 Gene denotes SPINT1 Gene:6692
372 390-422 Gene denotes Kunitz-type protease inhibitor 1 Gene:6692
373 425-431 Gene denotes SPINT2 Gene:10653
374 433-465 Gene denotes Kunitz-type protease inhibitor 2 Gene:10653
375 472-480 Gene denotes SERPINA1 Gene:5265
376 482-501 Gene denotes alpha-1-antitrypsin Gene:5265
377 706-714 Gene denotes SERPINA1 Gene:5265
378 719-725 Gene denotes SPINT2 Gene:10653
379 743-749 Gene denotes SPINT1 Gene:6692
380 167-168 Gene denotes S Gene:43740568
381 108-118 Species denotes SARS-CoV-2 Tax:2697049
382 920-930 Species denotes SARS-CoV-2 Tax:2697049
383 217-237 Disease denotes SARS-CoV-2 infection MESH:C000657245
384 298-317 Disease denotes SARS-CoV-2-infected MESH:C000657245
385 534-553 Disease denotes SARS-CoV-2-infected MESH:C000657245
386 572-580 Disease denotes infected MESH:D007239
387 605-614 Disease denotes infection MESH:D007239
388 770-789 Disease denotes SARS-CoV-2-infected MESH:C000657245
389 816-836 Disease denotes SARS-CoV-2 infection MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T133 0-187 Sentence denotes Host cell protease inhibitors interfere with the activity of proteases such as TMPRSS2 [33,34] that mediate SARS-CoV-2 cell entry by cleaving and activating the viral S protein [9,11,12].
T134 188-627 Sentence denotes An analysis of the effect of SARS-CoV-2 infection on host cell protease inhibitors using proteomics data from SARS-CoV-2-infected Caco2 cells [35] showed that the endogenous protease inhibitors SPINT1 (Kunitz-type protease inhibitor 1), SPINT2 (Kunitz-type protease inhibitor 2), and SERPINA1 (alpha-1-antitrypsin) are present at lower levels in SARS-CoV-2-infected cells than in non-infected control cells 24 h post-infection (Figure 4A).
T135 628-808 Sentence denotes Translatome data from the same dataset [35] indicated that the translation of SERPINA1 and SPINT2 (but not that of SPINT1) is also reduced in SARS-CoV-2-infected cells (Figure 4B).
T136 809-943 Sentence denotes Hence, SARS-CoV-2 infection results in the downregulation of endogenous protease inhibitors, which may support SARS-CoV-2 replication.
T137 944-1065 Sentence denotes Thus, compensation for downregulated endogenous protease inhibitors may contribute to the antiviral effects of aprotinin.