> top > docs > PMC:7665489 > spans > 138-1769 > annotations

PMC:7665489 / 138-1769 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
32 413-444 Gene denotes angiotensin converting enzyme 2 Gene:59272
33 446-451 Gene denotes hACE2 Gene:59272
34 524-529 Gene denotes hACE2 Gene:59272
35 763-768 Gene denotes hACE2 Gene:59272
36 1091-1096 Gene denotes hACE2 Gene:59272
37 1200-1205 Gene denotes hACE2 Gene:59272
38 1243-1248 Gene denotes hACE2 Gene:59272
39 1451-1455 Gene denotes ACE2 Gene:59272
40 1522-1526 Gene denotes ACE2 Gene:59272
41 374-375 Gene denotes S Gene:43740568
42 49-59 Species denotes SARS-CoV-2 Tax:2697049
43 245-256 Species denotes coronavirus Tax:11118
44 387-397 Species denotes SARS-CoV-2 Tax:2697049
45 407-412 Species denotes human Tax:9606
46 1622-1630 Species denotes patients Tax:9606
47 574-580 Chemical denotes glycan MESH:D011134
48 628-629 Chemical denotes N MESH:D009584
49 744-750 Chemical denotes glycan MESH:D011134
50 843-854 Chemical denotes sialic acid MESH:D019158
51 891-897 Chemical denotes GlcNAc MESH:D000117
52 918-926 Chemical denotes N-glycan
53 999-1011 Chemical denotes glycopeptide MESH:D006020
54 1016-1022 Chemical denotes glycan MESH:D011134
55 21-29 Disease denotes COVID-19 MESH:C000657245
56 1613-1621 Disease denotes COVID-19 MESH:C000657245
57 543-549 CellLine denotes HEK293 CVCL:0045

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T4 0-127 Sentence denotes The emergence of the COVID-19 pandemic caused by SARS-CoV-2 has created the need for development of new therapeutic strategies.
T5 128-240 Sentence denotes Understanding the mode of viral attachment, entry and replication has become a key aspect of such interventions.
T6 241-369 Sentence denotes The coronavirus surface features a trimeric spike (S) protein that is essential for viral attachment, entry and membrane fusion.
T7 370-463 Sentence denotes The S protein of SARS-CoV-2 binds to human angiotensin converting enzyme 2 (hACE2) for entry.
T8 464-556 Sentence denotes Herein, we describe glycomic and glycoproteomic analysis of hACE2 expressed in HEK293 cells.
T9 557-707 Sentence denotes We observed high glycan occupancy (73.2 to 100%) at all seven possible N-glycosylation sites and surprisingly detected one novel O-glycosylation site.
T10 708-940 Sentence denotes To deduce the detailed structure of glycan epitopes on hACE2 that may be involved in viral binding, we have characterized the terminal sialic acid linkages, the presence of bisecting GlcNAc, and the pattern of N-glycan fucosylation.
T11 941-1111 Sentence denotes We have conducted extensive manual interpretation of each glycopeptide and glycan spectrum, in addition to using bioinformatics tools to validate the hACE2 glycosylation.
T12 1112-1412 Sentence denotes Our elucidation of the site-specific glycosylation and its terminal orientations on the hACE2 receptor, along with the modeling of hACE2 glycosylation sites can aid in understanding the intriguing virus-receptor interactions and assist in the development of novel therapeutics to prevent viral entry.
T13 1413-1631 Sentence denotes The relevance of studying the role of ACE2 is further increased due to some recent reports about the varying ACE2 dependent complications with regard to age, sex, race, and pre-existing conditions of COVID-19 patients.