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PMC:7665489 / 129-1769 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
32 422-453 Gene denotes angiotensin converting enzyme 2 Gene:59272
33 455-460 Gene denotes hACE2 Gene:59272
34 533-538 Gene denotes hACE2 Gene:59272
35 772-777 Gene denotes hACE2 Gene:59272
36 1100-1105 Gene denotes hACE2 Gene:59272
37 1209-1214 Gene denotes hACE2 Gene:59272
38 1252-1257 Gene denotes hACE2 Gene:59272
39 1460-1464 Gene denotes ACE2 Gene:59272
40 1531-1535 Gene denotes ACE2 Gene:59272
41 383-384 Gene denotes S Gene:43740568
42 58-68 Species denotes SARS-CoV-2 Tax:2697049
43 254-265 Species denotes coronavirus Tax:11118
44 396-406 Species denotes SARS-CoV-2 Tax:2697049
45 416-421 Species denotes human Tax:9606
46 1631-1639 Species denotes patients Tax:9606
47 583-589 Chemical denotes glycan MESH:D011134
48 637-638 Chemical denotes N MESH:D009584
49 753-759 Chemical denotes glycan MESH:D011134
50 852-863 Chemical denotes sialic acid MESH:D019158
51 900-906 Chemical denotes GlcNAc MESH:D000117
52 927-935 Chemical denotes N-glycan
53 1008-1020 Chemical denotes glycopeptide MESH:D006020
54 1025-1031 Chemical denotes glycan MESH:D011134
55 30-38 Disease denotes COVID-19 MESH:C000657245
56 1622-1630 Disease denotes COVID-19 MESH:C000657245
57 552-558 CellLine denotes HEK293 CVCL:0045

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-8 Sentence denotes Abstract
T4 9-136 Sentence denotes The emergence of the COVID-19 pandemic caused by SARS-CoV-2 has created the need for development of new therapeutic strategies.
T5 137-249 Sentence denotes Understanding the mode of viral attachment, entry and replication has become a key aspect of such interventions.
T6 250-378 Sentence denotes The coronavirus surface features a trimeric spike (S) protein that is essential for viral attachment, entry and membrane fusion.
T7 379-472 Sentence denotes The S protein of SARS-CoV-2 binds to human angiotensin converting enzyme 2 (hACE2) for entry.
T8 473-565 Sentence denotes Herein, we describe glycomic and glycoproteomic analysis of hACE2 expressed in HEK293 cells.
T9 566-716 Sentence denotes We observed high glycan occupancy (73.2 to 100%) at all seven possible N-glycosylation sites and surprisingly detected one novel O-glycosylation site.
T10 717-949 Sentence denotes To deduce the detailed structure of glycan epitopes on hACE2 that may be involved in viral binding, we have characterized the terminal sialic acid linkages, the presence of bisecting GlcNAc, and the pattern of N-glycan fucosylation.
T11 950-1120 Sentence denotes We have conducted extensive manual interpretation of each glycopeptide and glycan spectrum, in addition to using bioinformatics tools to validate the hACE2 glycosylation.
T12 1121-1421 Sentence denotes Our elucidation of the site-specific glycosylation and its terminal orientations on the hACE2 receptor, along with the modeling of hACE2 glycosylation sites can aid in understanding the intriguing virus-receptor interactions and assist in the development of novel therapeutics to prevent viral entry.
T13 1422-1640 Sentence denotes The relevance of studying the role of ACE2 is further increased due to some recent reports about the varying ACE2 dependent complications with regard to age, sex, race, and pre-existing conditions of COVID-19 patients.