> top > docs > PMC:7665489 > annotations

PMC:7665489 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 61-71 Species denotes SARS-CoV-2 Tax:2697049
4 72-77 Species denotes human Tax:9606
5 34-35 Chemical denotes N MESH:D009584
32 551-582 Gene denotes angiotensin converting enzyme 2 Gene:59272
33 584-589 Gene denotes hACE2 Gene:59272
34 662-667 Gene denotes hACE2 Gene:59272
35 901-906 Gene denotes hACE2 Gene:59272
36 1229-1234 Gene denotes hACE2 Gene:59272
37 1338-1343 Gene denotes hACE2 Gene:59272
38 1381-1386 Gene denotes hACE2 Gene:59272
39 1589-1593 Gene denotes ACE2 Gene:59272
40 1660-1664 Gene denotes ACE2 Gene:59272
41 512-513 Gene denotes S Gene:43740568
42 187-197 Species denotes SARS-CoV-2 Tax:2697049
43 383-394 Species denotes coronavirus Tax:11118
44 525-535 Species denotes SARS-CoV-2 Tax:2697049
45 545-550 Species denotes human Tax:9606
46 1760-1768 Species denotes patients Tax:9606
47 712-718 Chemical denotes glycan MESH:D011134
48 766-767 Chemical denotes N MESH:D009584
49 882-888 Chemical denotes glycan MESH:D011134
50 981-992 Chemical denotes sialic acid MESH:D019158
51 1029-1035 Chemical denotes GlcNAc MESH:D000117
52 1056-1064 Chemical denotes N-glycan
53 1137-1149 Chemical denotes glycopeptide MESH:D006020
54 1154-1160 Chemical denotes glycan MESH:D011134
55 159-167 Disease denotes COVID-19 MESH:C000657245
56 1751-1759 Disease denotes COVID-19 MESH:C000657245
57 681-687 CellLine denotes HEK293 CVCL:0045

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes Comprehensive characterization of N- and O- glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2
T2 120-128 Sentence denotes Abstract
T3 129-137 Sentence denotes Abstract
T4 138-265 Sentence denotes The emergence of the COVID-19 pandemic caused by SARS-CoV-2 has created the need for development of new therapeutic strategies.
T5 266-378 Sentence denotes Understanding the mode of viral attachment, entry and replication has become a key aspect of such interventions.
T6 379-507 Sentence denotes The coronavirus surface features a trimeric spike (S) protein that is essential for viral attachment, entry and membrane fusion.
T7 508-601 Sentence denotes The S protein of SARS-CoV-2 binds to human angiotensin converting enzyme 2 (hACE2) for entry.
T8 602-694 Sentence denotes Herein, we describe glycomic and glycoproteomic analysis of hACE2 expressed in HEK293 cells.
T9 695-845 Sentence denotes We observed high glycan occupancy (73.2 to 100%) at all seven possible N-glycosylation sites and surprisingly detected one novel O-glycosylation site.
T10 846-1078 Sentence denotes To deduce the detailed structure of glycan epitopes on hACE2 that may be involved in viral binding, we have characterized the terminal sialic acid linkages, the presence of bisecting GlcNAc, and the pattern of N-glycan fucosylation.
T11 1079-1249 Sentence denotes We have conducted extensive manual interpretation of each glycopeptide and glycan spectrum, in addition to using bioinformatics tools to validate the hACE2 glycosylation.
T12 1250-1550 Sentence denotes Our elucidation of the site-specific glycosylation and its terminal orientations on the hACE2 receptor, along with the modeling of hACE2 glycosylation sites can aid in understanding the intriguing virus-receptor interactions and assist in the development of novel therapeutics to prevent viral entry.
T13 1551-1769 Sentence denotes The relevance of studying the role of ACE2 is further increased due to some recent reports about the varying ACE2 dependent complications with regard to age, sex, race, and pre-existing conditions of COVID-19 patients.