PMC:7665480 / 27616-29476 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"558","span":{"begin":104,"end":114},"obj":"Species"},{"id":"559","span":{"begin":403,"end":411},"obj":"Species"},{"id":"560","span":{"begin":89,"end":98},"obj":"Disease"},{"id":"561","span":{"begin":247,"end":262},"obj":"Disease"},{"id":"562","span":{"begin":349,"end":362},"obj":"Disease"},{"id":"563","span":{"begin":481,"end":489},"obj":"Disease"},{"id":"565","span":{"begin":1449,"end":1462},"obj":"Disease"},{"id":"637","span":{"begin":1744,"end":1752},"obj":"Disease"},{"id":"639","span":{"begin":1753,"end":1777},"obj":"Disease"}],"attributes":[{"id":"A558","pred":"tao:has_database_id","subj":"558","obj":"Tax:2697049"},{"id":"A559","pred":"tao:has_database_id","subj":"559","obj":"Tax:9606"},{"id":"A560","pred":"tao:has_database_id","subj":"560","obj":"MESH:D007239"},{"id":"A561","pred":"tao:has_database_id","subj":"561","obj":"MESH:D001102"},{"id":"A562","pred":"tao:has_database_id","subj":"562","obj":"MESH:D006333"},{"id":"A563","pred":"tao:has_database_id","subj":"563","obj":"MESH:C000657245"},{"id":"A637","pred":"tao:has_database_id","subj":"637","obj":"MESH:C000657245"},{"id":"A639","pred":"tao:has_database_id","subj":"639","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"CONCLUSION\nTo date, few anecdotal results have been reported in the literature regarding infection with SARS-CoV-2 in heart transplant recipients. Our strategy primarily consisted of lowering the dose of their immunosuppressive therapy facing the viral infection and introducing corticosteroids to reduce the hyperinflammatory state and the risk of graft failure. Despite the limited number of affected patients, this report suggests that special considerations should be given to COVID-19 in the heart transplant population. Given the information available in the literature, the case fatality rate for this vulnerable cohort is doubled that of the overall population and the best therapeutic strategy remains unclear. Prompt referral to a transplant centre following onset of first symptoms is required in order to treat the disease immediately and avoid progression to severe forms.\nConflict of interest: none declared.\n\nAuthor contributions\nRaphael Caraffa: Writing—original draft. Lorenzo Bagozzi: Data curation. Alessandro Fiocco: Writing—original draft. Olimpia Bifulco: Formal analysis. Matteo Nadali: Methodology. Matteo Ponzoni: Data curation. Massimiliano Carrozzini: Supervision. Giuseppe Toscano: Validation. Angela Pompea Fraiese: Validation. Marco Metra: Writing—review \u0026 editing. Carlo Maria Lombardi: Writing—review \u0026 editing. Francesco Serafini: Data curation. Angela Ribola: Data curation. Vjola Jorgji: Writing—review \u0026 editing. Tomaso Bottio: Conceptualization; Writing—review \u0026 editing. Gino Gerosa: Conceptualization.\n\nReviewer information\nEuropean Journal of Cardio-Thoracic Surgery thanks Sai Bhagra and the other, anonymous reviewer(s) for their contribution to the peer review process of this article. Abbreviations\nCOVID-19 Coronavirus disease 2019\nIQR Interquartile range\nSARS-CoV-2 Severe acute respiratory syndrome coronavirus-2"}

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{"project":"testtesttest","denotations":[{"id":"T146","span":{"begin":118,"end":123},"obj":"Body_part"},{"id":"T150","span":{"begin":497,"end":502},"obj":"Body_part"},{"id":"T154","span":{"begin":1704,"end":1711},"obj":"Body_part"}],"attributes":[{"id":"A146","pred":"uberon_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A147","pred":"uberon_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"A148","pred":"uberon_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"A149","pred":"uberon_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/UBERON_0015230"},{"id":"A150","pred":"uberon_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A151","pred":"uberon_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"A152","pred":"uberon_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"A153","pred":"uberon_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/UBERON_0015230"},{"id":"A154","pred":"uberon_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/UBERON_0004529"}],"text":"CONCLUSION\nTo date, few anecdotal results have been reported in the literature regarding infection with SARS-CoV-2 in heart transplant recipients. Our strategy primarily consisted of lowering the dose of their immunosuppressive therapy facing the viral infection and introducing corticosteroids to reduce the hyperinflammatory state and the risk of graft failure. Despite the limited number of affected patients, this report suggests that special considerations should be given to COVID-19 in the heart transplant population. Given the information available in the literature, the case fatality rate for this vulnerable cohort is doubled that of the overall population and the best therapeutic strategy remains unclear. Prompt referral to a transplant centre following onset of first symptoms is required in order to treat the disease immediately and avoid progression to severe forms.\nConflict of interest: none declared.\n\nAuthor contributions\nRaphael Caraffa: Writing—original draft. Lorenzo Bagozzi: Data curation. Alessandro Fiocco: Writing—original draft. Olimpia Bifulco: Formal analysis. Matteo Nadali: Methodology. Matteo Ponzoni: Data curation. Massimiliano Carrozzini: Supervision. Giuseppe Toscano: Validation. Angela Pompea Fraiese: Validation. Marco Metra: Writing—review \u0026 editing. Carlo Maria Lombardi: Writing—review \u0026 editing. Francesco Serafini: Data curation. Angela Ribola: Data curation. Vjola Jorgji: Writing—review \u0026 editing. Tomaso Bottio: Conceptualization; Writing—review \u0026 editing. Gino Gerosa: Conceptualization.\n\nReviewer information\nEuropean Journal of Cardio-Thoracic Surgery thanks Sai Bhagra and the other, anonymous reviewer(s) for their contribution to the peer review process of this article. Abbreviations\nCOVID-19 Coronavirus disease 2019\nIQR Interquartile range\nSARS-CoV-2 Severe acute respiratory syndrome coronavirus-2"}