PMC:7665480 / 14776-15620 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"339","span":{"begin":55,"end":63},"obj":"Species"},{"id":"340","span":{"begin":102,"end":112},"obj":"Species"},{"id":"341","span":{"begin":270,"end":278},"obj":"Species"},{"id":"342","span":{"begin":375,"end":383},"obj":"Species"},{"id":"343","span":{"begin":475,"end":483},"obj":"Species"},{"id":"344","span":{"begin":706,"end":713},"obj":"Species"},{"id":"345","span":{"begin":88,"end":96},"obj":"Disease"},{"id":"346","span":{"begin":155,"end":170},"obj":"Disease"},{"id":"347","span":{"begin":250,"end":266},"obj":"Disease"},{"id":"348","span":{"begin":389,"end":397},"obj":"Disease"},{"id":"349","span":{"begin":514,"end":522},"obj":"Disease"},{"id":"350","span":{"begin":540,"end":547},"obj":"Disease"},{"id":"351","span":{"begin":615,"end":630},"obj":"Disease"}],"attributes":[{"id":"A339","pred":"tao:has_database_id","subj":"339","obj":"Tax:9606"},{"id":"A340","pred":"tao:has_database_id","subj":"340","obj":"Tax:2697049"},{"id":"A341","pred":"tao:has_database_id","subj":"341","obj":"Tax:9606"},{"id":"A342","pred":"tao:has_database_id","subj":"342","obj":"Tax:9606"},{"id":"A343","pred":"tao:has_database_id","subj":"343","obj":"Tax:9606"},{"id":"A344","pred":"tao:has_database_id","subj":"344","obj":"Tax:9606"},{"id":"A345","pred":"tao:has_database_id","subj":"345","obj":"MESH:D007239"},{"id":"A346","pred":"tao:has_database_id","subj":"346","obj":"MESH:D001102"},{"id":"A347","pred":"tao:has_database_id","subj":"347","obj":"MESH:D001102"},{"id":"A348","pred":"tao:has_database_id","subj":"348","obj":"MESH:C000657245"},{"id":"A349","pred":"tao:has_database_id","subj":"349","obj":"MESH:C000657245"},{"id":"A350","pred":"tao:has_database_id","subj":"350","obj":"MESH:D000860"},{"id":"A351","pred":"tao:has_database_id","subj":"351","obj":"MESH:D008231"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Lacking any strong evidence regarding the treatment of patients with a heart transplant infected with SARS-CoV-2, we faced a new challenge in managing the viral infection in this immunosuppressed population. Strengthened by our experience with other viral infections in patients with heart transplants, especially cytomegalovirus, we followed the same management protocol in patients with COVID-19 [17]. Our first steps consisted of reducing immunosuppressive therapy in the patients with severe clinical forms of COVID-19, i.e. those with hypoxia who required hospitalization. This strategy was adopted due to the lymphocytopenia characterizing this syndrome. For the milder form of the disease (i.e. the patient in self-quarantine at home), we opted not to reduce immunosuppression, instead implementing a close telephone monitoring protocol."}

{"project":"TEST0","denotations":[{"id":"33084868-191-197-8433","span":{"begin":399,"end":401},"obj":"[\"27340928\"]"}],"text":"Lacking any strong evidence regarding the treatment of patients with a heart transplant infected with SARS-CoV-2, we faced a new challenge in managing the viral infection in this immunosuppressed population. Strengthened by our experience with other viral infections in patients with heart transplants, especially cytomegalovirus, we followed the same management protocol in patients with COVID-19 [17]. Our first steps consisted of reducing immunosuppressive therapy in the patients with severe clinical forms of COVID-19, i.e. those with hypoxia who required hospitalization. This strategy was adopted due to the lymphocytopenia characterizing this syndrome. For the milder form of the disease (i.e. the patient in self-quarantine at home), we opted not to reduce immunosuppression, instead implementing a close telephone monitoring protocol."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T37","span":{"begin":540,"end":547},"obj":"Phenotype"},{"id":"T38","span":{"begin":615,"end":630},"obj":"Phenotype"}],"attributes":[{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0001888"}],"text":"Lacking any strong evidence regarding the treatment of patients with a heart transplant infected with SARS-CoV-2, we faced a new challenge in managing the viral infection in this immunosuppressed population. Strengthened by our experience with other viral infections in patients with heart transplants, especially cytomegalovirus, we followed the same management protocol in patients with COVID-19 [17]. Our first steps consisted of reducing immunosuppressive therapy in the patients with severe clinical forms of COVID-19, i.e. those with hypoxia who required hospitalization. This strategy was adopted due to the lymphocytopenia characterizing this syndrome. For the milder form of the disease (i.e. the patient in self-quarantine at home), we opted not to reduce immunosuppression, instead implementing a close telephone monitoring protocol."}

{"project":"LitCovid-sentences","denotations":[{"id":"T181","span":{"begin":0,"end":207},"obj":"Sentence"},{"id":"T182","span":{"begin":208,"end":403},"obj":"Sentence"},{"id":"T183","span":{"begin":404,"end":577},"obj":"Sentence"},{"id":"T184","span":{"begin":578,"end":660},"obj":"Sentence"},{"id":"T185","span":{"begin":661,"end":844},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Lacking any strong evidence regarding the treatment of patients with a heart transplant infected with SARS-CoV-2, we faced a new challenge in managing the viral infection in this immunosuppressed population. Strengthened by our experience with other viral infections in patients with heart transplants, especially cytomegalovirus, we followed the same management protocol in patients with COVID-19 [17]. Our first steps consisted of reducing immunosuppressive therapy in the patients with severe clinical forms of COVID-19, i.e. those with hypoxia who required hospitalization. This strategy was adopted due to the lymphocytopenia characterizing this syndrome. For the milder form of the disease (i.e. the patient in self-quarantine at home), we opted not to reduce immunosuppression, instead implementing a close telephone monitoring protocol."}