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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
321 48-56 Species denotes patients Tax:9606
322 218-227 Species denotes mammalian Tax:9606
323 187-193 Chemical denotes purine MESH:C030985
324 239-248 Chemical denotes rapamycin MESH:D020123
325 394-410 Disease denotes viral infections MESH:D001102
339 467-475 Species denotes patients Tax:9606
340 514-524 Species denotes SARS-CoV-2 Tax:2697049
341 682-690 Species denotes patients Tax:9606
342 787-795 Species denotes patients Tax:9606
343 887-895 Species denotes patients Tax:9606
344 1118-1125 Species denotes patient Tax:9606
345 500-508 Disease denotes infected MESH:D007239
346 567-582 Disease denotes viral infection MESH:D001102
347 662-678 Disease denotes viral infections MESH:D001102
348 801-809 Disease denotes COVID-19 MESH:C000657245
349 926-934 Disease denotes COVID-19 MESH:C000657245
350 952-959 Disease denotes hypoxia MESH:D000860
351 1027-1042 Disease denotes lymphocytopenia MESH:D008231
356 1321-1329 Species denotes patients Tax:9606
357 1358-1366 Disease denotes COVID-19 MESH:C000657245
358 1452-1465 Disease denotes graft failure MESH:D006333
359 1495-1515 Disease denotes immunological memory MESH:D007153
361 1907-1918 Disease denotes lung damage MESH:D008171
369 2325-2344 Gene denotes cytochrome-P450-3A4 Gene:1576
370 2486-2505 Gene denotes cytochrome-P450-3A4 Gene:1576
371 2624-2643 Gene denotes cytochrome-P450-3A4 Gene:1576
372 2660-2679 Gene denotes cytochrome-P450-2C8 Gene:1558
373 2146-2156 Species denotes SARS-CoV-2 Tax:2697049
374 2385-2394 Chemical denotes lopinavir MESH:D061466
375 2544-2562 Chemical denotes hydroxychloroquine MESH:D006886
389 3728-3736 Species denotes patients Tax:9606
390 4525-4533 Species denotes patients Tax:9606
391 3667-3685 Chemical denotes hydroxychloroquine MESH:D006886
392 3855-3873 Chemical denotes hydroxychloroquine MESH:D006886
393 4308-4326 Chemical denotes hydroxychloroquine MESH:D006886
394 4437-4455 Chemical denotes hydroxychloroquine MESH:D006886
395 3066-3078 Disease denotes inflammation MESH:D007249
396 3129-3149 Disease denotes SARS-CoV-2 infection MESH:C000657245
397 3167-3202 Disease denotes acute respiratory distress syndrome MESH:D012128
398 3562-3569 Disease denotes hypoxia MESH:D000860
399 3762-3770 Disease denotes COVID-19 MESH:C000657245
400 4490-4499 Disease denotes mortality MESH:D003643
401 4516-4524 Disease denotes COVID-19 MESH:C000657245
414 4601-4609 Species denotes patients Tax:9606
415 4845-4853 Species denotes patients Tax:9606
416 5098-5106 Species denotes patients Tax:9606
417 4628-4637 Chemical denotes ritonavir MESH:D019438
418 4638-4647 Chemical denotes lopinavir MESH:D061466
419 5052-5061 Chemical denotes ritonavir MESH:D019438
420 5062-5071 Chemical denotes lopinavir MESH:D061466
421 5179-5197 Chemical denotes hydroxychloroquine MESH:D006886
422 5202-5214 Chemical denotes azithromycin MESH:D017963
423 4972-4980 Disease denotes COVID-19 MESH:C000657245
424 5123-5131 Disease denotes toxicity MESH:D064420
425 5243-5251 Disease denotes COVID-19 MESH:C000657245
428 5421-5434 Disease denotes graft failure MESH:D006333
429 5808-5816 Disease denotes COVID-19 MESH:C000657245
434 6131-6143 Chemical denotes beta-lactams MESH:D047090
435 6148-6158 Chemical denotes macrolides MESH:D018942
436 5921-5941 Disease denotes bacterial infections MESH:D001424
437 6079-6094 Disease denotes lymphocytopenia MESH:D008231
447 6164-6171 Species denotes patient Tax:9606
448 6400-6407 Species denotes patient Tax:9606
449 6574-6584 Species denotes SARS-CoV-2 Tax:2697049
450 6428-6438 Chemical denotes everolimus MESH:D000068338
451 6686-6696 Chemical denotes everolimus MESH:D000068338
452 6279-6288 Disease denotes infection MESH:D007239
453 6463-6488 Disease denotes Epstein-Barr virus copies MESH:D020031
454 6712-6720 Disease denotes COVID-19 MESH:C000657245
455 6894-6914 Disease denotes SARS-CoV-2 infection MESH:C000657245
459 7100-7110 Species denotes SARS-COV-2 Tax:2697049
460 7281-7289 Species denotes patients Tax:9606
461 7111-7121 Disease denotes infections MESH:D007239
464 7500-7510 Species denotes SARS-COV-2 Tax:2697049
465 7511-7521 Disease denotes infections MESH:D007239
480 9830-9835 Gene denotes IFN-b Gene:3456
481 7785-7793 Species denotes patients Tax:9606
482 9553-9572 Chemical denotes Lopinavir/ritonavir MESH:C558899
483 9614-9624 Chemical denotes Remdesivir MESH:C000606551
484 9984-9991 Chemical denotes Steroid MESH:D013256
485 8197-8209 Disease denotes hypertension MESH:D006973
486 8256-8273 Disease denotes Diabetes mellitus MESH:D003920
487 8320-8343 Disease denotes Chronic kidney diseasea MESH:D051436
488 8559-8567 Disease denotes COVID-19 MESH:C000657245
489 8584-8589 Disease denotes Fever MESH:D005334
490 8641-8645 Disease denotes pain MESH:D010146
491 8690-8709 Disease denotes Shortness of breath MESH:D004417
492 8713-8718 Disease denotes cough MESH:D003371
493 9470-9478 Disease denotes COVID-19 MESH:C000657245
499 10823-10828 Gene denotes IFN-b Gene:3456
500 10830-10845 Gene denotes interferon-beta Gene:3456
501 10967-10977 Species denotes SARS-CoV-2 Tax:2697049
502 10979-11026 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
503 10768-10798 Disease denotes cardiac allograft vasculopathy MESH:D006331
505 11121-11130 Disease denotes mortality MESH:D003643
520 11441-11451 Species denotes SARS-CoV-2 Tax:2697049
521 11457-11464 Species denotes patient Tax:9606
522 11662-11670 Species denotes patients Tax:9606
523 11727-11737 Species denotes SARS-CoV-2 Tax:2697049
524 11996-12003 Species denotes patient Tax:9606
525 11351-11360 Disease denotes mortality MESH:D003643
526 11422-11431 Disease denotes infection MESH:D007239
527 11508-11538 Disease denotes cardiac allograft vasculopathy MESH:D006331
528 11630-11639 Disease denotes mortality MESH:D003643
529 11676-11690 Disease denotes cardiovascular MESH:D002318
530 11713-11721 Disease denotes infected MESH:D007239
531 11921-11926 Disease denotes death MESH:D003643
532 12055-12061 Disease denotes sepsis MESH:D018805
533 12115-12124 Disease denotes infection MESH:D007239
540 12433-12441 Species denotes patients Tax:9606
541 12556-12564 Species denotes patients Tax:9606
542 12273-12292 Disease denotes respiratory disease MESH:D012140
543 12366-12382 Disease denotes ischaemic stroke MESH:D002544
544 12447-12455 Disease denotes COVID-19 MESH:C000657245
545 12528-12546 Disease denotes hypercoagulability MESH:D019851
549 13200-13208 Species denotes patients Tax:9606
550 12927-12935 Disease denotes COVID-19 MESH:C000657245
551 12936-12946 Disease denotes infections MESH:D007239

TEST0

Id Subject Object Predicate Lexical cue
33084868-191-197-8433 811-813 ["27340928"] denotes 17
33084868-111-117-8434 1368-1370 ["32233067"] denotes 18
33084868-115-121-8435 1372-1374 ["32181990"] denotes 19
33084868-232-238-8436 1862-1864 ["32362390"] denotes 20
33084868-236-242-8437 1866-1868 ["32243698"] denotes 21
33084868-29-35-8438 3490-3492 ["32362390"] denotes 20
33084868-138-144-8439 4131-4133 ["32379955"] denotes 24
33084868-125-131-8440 6759-6761 ["32574238"] denotes 27
33084868-123-129-8441 7182-7184 ["32362394"] denotes 13
33084868-11-16-8442 7564-7565 ["32362394"] denotes 3
33084868-29-34-8443 7584-7585 ["32319218"] denotes 5
33084868-64-69-8444 7623-7624 ["32315122"] denotes 7
33084868-111-117-8445 7676-7678 ["32330356"] denotes 10
33084868-156-162-8446 7725-7727 ["32301155"] denotes 12
33084868-171-177-8447 7742-7744 ["32542914"] denotes 13
33084868-118-124-8448 12502-12504 ["32268022"] denotes 28
33084868-200-206-8449 12584-12586 ["32316063"] denotes 29

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T37 952-959 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T38 1027-1042 Phenotype denotes lymphocytopenia http://purl.obolibrary.org/obo/HP_0001888
T39 1759-1773 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T40 3173-3193 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T41 3562-3569 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T42 6079-6094 Phenotype denotes lymphocytopenia http://purl.obolibrary.org/obo/HP_0001888
T43 8197-8209 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T44 8256-8273 Phenotype denotes Diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T45 8390-8402 Phenotype denotes Lung disease http://purl.obolibrary.org/obo/HP_0002088
T46 8584-8589 Phenotype denotes Fever http://purl.obolibrary.org/obo/HP_0001945
T47 8635-8645 Phenotype denotes Chest pain http://purl.obolibrary.org/obo/HP_0100749
T48 8690-8709 Phenotype denotes Shortness of breath http://purl.obolibrary.org/obo/HP_0002098
T49 8713-8718 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T50 12055-12061 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T51 12366-12382 Phenotype denotes ischaemic stroke http://purl.obolibrary.org/obo/HP_0002140
T52 12528-12546 Phenotype denotes hypercoagulability http://purl.obolibrary.org/obo/HP_0100724

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T178 0-10 Sentence denotes DISCUSSION
T179 11-260 Sentence denotes Chronic immunosuppressive therapy in patients with heart transplants is framed in a well-established protocol that includes calcineurin inhibitors possibly in combination with purine synthesis inhibitors or mammalian targets of rapamycin inhibitors.
T180 261-411 Sentence denotes This therapeutic scheme is effective in deactivating the lymphocytes of the adaptive immune response, which is primarily involved in viral infections.
T181 412-619 Sentence denotes Lacking any strong evidence regarding the treatment of patients with a heart transplant infected with SARS-CoV-2, we faced a new challenge in managing the viral infection in this immunosuppressed population.
T182 620-815 Sentence denotes Strengthened by our experience with other viral infections in patients with heart transplants, especially cytomegalovirus, we followed the same management protocol in patients with COVID-19 [17].
T183 816-989 Sentence denotes Our first steps consisted of reducing immunosuppressive therapy in the patients with severe clinical forms of COVID-19, i.e. those with hypoxia who required hospitalization.
T184 990-1072 Sentence denotes This strategy was adopted due to the lymphocytopenia characterizing this syndrome.
T185 1073-1256 Sentence denotes For the milder form of the disease (i.e. the patient in self-quarantine at home), we opted not to reduce immunosuppression, instead implementing a close telephone monitoring protocol.
T186 1257-1376 Sentence denotes Total suspension of immunosuppression has been proposed in some patients with kidney transplants and COVID-19 [18, 19].
T187 1377-1572 Sentence denotes However, we were concerned that suspending immunosuppression could lead to graft failure due to rebound activation of immunological memory, potentially exacerbated by the hyperinflammatory state.
T188 1573-1870 Sentence denotes Furthermore, we do not yet know if the anti-inflammatory effect of chronic immunosuppressive therapy plays an undetermined role in the ‘cell damage cascade’ triggered by an uncontrolled cytokine storm and lymphocyte–macrophage activation, as has already been speculated in the literature [20, 21].
T189 1871-2041 Sentence denotes Indeed, some evidence suggests that lung damage in the severe forms of the disease is essentially due to immune hyperactivation rather than viral pathogenesis per se [6].
T190 2042-2189 Sentence denotes Conversely, we know that pharmacological interferences occurs between the antiviral drugs used to treat SARS-CoV-2 and calcineurin inhibitors [16].
T191 2190-2345 Sentence denotes The main issue of drug–drug interactions is an increased in immunosuppressant plasma concentrations due to their shared metabolism via cytochrome-P450-3A4.
T192 2346-2506 Sentence denotes In particular, the interaction between lopinavir and calcineurin inhibitors has already been characterized as being based on suppression of cytochrome-P450-3A4.
T193 2507-2604 Sentence denotes In contrast, the interaction between hydroxychloroquine and calcineurin inhibitors is less clear.
T194 2605-2760 Sentence denotes Its metabolism via cytochrome-P450-3A4, as well as via cytochrome-P450-2C8, might theoretically increase the plasma concentration of the immunosuppressant.
T195 2761-2833 Sentence denotes Consequently, close monitoring of immunosuppressant levels is warranted.
T196 2834-2985 Sentence denotes Therefore, on one hand we chose to reduce chronic immunosuppressive therapy; on the other, we introduced corticosteroid therapy for 2 critical reasons.
T197 2986-3089 Sentence denotes First, we tried to reduce the hyperinflammatory state and the overproduction of inflammation mediators.
T198 3090-3230 Sentence denotes However, the use of corticosteroids in SARS-CoV-2 infection for treatment of acute respiratory distress syndrome remains controversial [22].
T199 3231-3460 Sentence denotes A retrospective analysis by Wang et al. in a Wuhan cohort showed that administration of early, low-dose and short-term corticosteroids was associated with faster improvement of clinical symptoms and absorption of lung focus [23].
T200 3461-3626 Sentence denotes Moreover, Siddiqi and Mehra [20] proposed the use of corticosteroids in immunosuppressed states when hypoxia is highlighted in moderate to severe clinical scenarios.
T201 3627-3737 Sentence denotes In this regard, supportive therapy with hydroxychloroquine was also administered in all hospitalized patients.
T202 3738-3992 Sentence denotes At the beginning of the COVID-19 pandemic, first reports and many national treatment guidelines suggested the use of hydroxychloroquine due to the anti-inflammatory and broad-spectrum antiviral effects observed with the severe acute respiratory syndrome.
T203 3993-4135 Sentence denotes However, despite its common use, efficacy and safety were not confirmed by several dedicated observational studies and randomized trials [24].
T204 4136-4144 Sentence denotes The U.S.
T205 4145-4241 Sentence denotes Food and Drug Administration subsequently revoked emergency use authorization for the drug [25].
T206 4242-4373 Sentence denotes On 17 June 2020, the World Health Organization announced that the hydroxychloroquine arm of the Solidarity Trial was being stopped.
T207 4374-4571 Sentence denotes Data from major ongoing randomized clinical trials showed that hydroxychloroquine does not result in a reduction in mortality of hospitalized COVID-19 patients, when compared with standard of care.
T208 4572-4656 Sentence denotes Only 2 of our 5 hospitalized patients were treated with ritonavir/lopinavir therapy.
T209 4657-4836 Sentence denotes At the beginning of the Northern Italy pandemic, the Italian government agency for the regulation of drugs developed several protocols for off-label usage of antiretrovirals [26].
T210 4837-4981 Sentence denotes These 2 patients had fulfilled inclusion criteria for enrolment in one of the first randomized clinical trials for these drugs against COVID-19.
T211 4982-5280 Sentence denotes With increasing evidence of both the absence of clinical benefit from ritonavir/lopinavir in the more seriously ill patients and the risk of toxicity associated with the combined administration of hydroxychloroquine and azithromycin, their usage in the general COVID-19 population has been limited.
T212 5281-5357 Sentence denotes As a result, we have abandoned their use in our heart transplant population.
T213 5358-5490 Sentence denotes Second, by introducing corticosteroids, we lowered the risk of graft failure due to the reduction in the dose of immunosuppressants.
T214 5491-5623 Sentence denotes Nevertheless, given the debated effects of corticosteroids, the dose introduced was of medium proportion, as already suggested [23].
T215 5624-5817 Sentence denotes Therefore, we hypothesize that the broad-spectrum immunomodulatory effect of corticosteroids can help in the clinical management of transplant recipients affected with severe forms of COVID-19.
T216 5818-6095 Sentence denotes Not least, we considered the administration of broad-spectrum antibiotic therapy to avoid superimposed bacterial infections that would have a detrimental effect on the prognosis due to immunosuppression and corticosteroids, and the reduction of defenses due to lymphocytopenia.
T217 6096-6159 Sentence denotes We mainly opted for broad spectrum beta-lactams and macrolides.
T218 6160-6309 Sentence denotes The patient who self-quarantined at home, despite presenting with similar onset symptoms, experienced a mild course of infection of shorter duration.
T219 6310-6394 Sentence denotes The nasopharyngeal swab test was performed when the person was already asymptomatic.
T220 6395-6489 Sentence denotes This patient was the only one on everolimus due to a high number of Epstein-Barr virus copies.
T221 6490-6633 Sentence denotes Although there are speculations about this drug’s antiviral activity in relation to SARS-CoV-2, no conclusions can be drawn from a single case.
T222 6634-6763 Sentence denotes Some authors claim a possible beneficial effect for everolimus as therapy for COVID-19 due to its immunomodulatory activity [27].
T223 6764-7058 Sentence denotes Moreover, the anti-replicative effect of controlling the spread of Epstein–Barr virus or cytomegalovirus can also be promising in SARS-CoV-2 infection on the basis of its ability to reduce mRNA translation, ribosome biogenesis, protein synthesis, mitochondrial metabolism and viral replication.
T224 7059-7186 Sentence denotes Table 2 summarizes the available data on SARS-COV-2 infections in heart transplant recipients from reported case series [3–13].
T225 7187-7259 Sentence denotes When we analysed the overall data, the case-fatality-rate was about 20%.
T226 7260-7350 Sentence denotes More than 80% of the patients were hospitalized, and half required intensive care support.
T227 7351-7460 Sentence denotes The best immunosuppressive strategy is still being debated, in accordance with 60% of dosage reduction cases.
T228 7461-7469 Sentence denotes Table 2:
T229 7471-7552 Sentence denotes Summary of available data on SARS-COV-2 infections in heart transplant recipients
T230 7553-7774 Sentence denotes Li et al. [3] Mathies et al. [5] Holzhauser et al. [6] Hsu et al. [7] Latif et al. [8] Hoek et al. [9] Kates et al. [10] Decker et al. [11] Fernandez- Ruiz et al. [12] Lee et al. [13] Caraffa et al Total, n (%)
T231 7775-7831 Sentence denotes Number of patients 2 1 2 1 28 4 1 1 4 4 6 54
T232 7832-7856 Sentence denotes Baseline characteristics
T233 7857-7985 Sentence denotes  Age (years) 51; 43 77 59; 75 39 64 (53.3–70.5) 75; 65; 51; 50 74 62 64; 67; 63; 38 15; 25; 1.1; 2.4 67 (59–74) 59.1
T234 7986-8130 Sentence denotes  Time from HTx (years) 16.2; 2.6 17 8; 20 3 8.6 (4.2–14.5) 21; 10; 10; 6 23 0.4 13.8; 10; 17.9; 8.7 0.4; 3; 0.5; 2 12 (4.0–17.5) 9.4
T235 8131-8186 Sentence denotes  Male gender 2 1 1 1 22 3 1 1 4 1 5 42 (78)
T236 8187-8254 Sentence denotes  Arterial hypertension 0 1 2 1 20 NA NA 0 2 0 5 31 (63)
T237 8255-8318 Sentence denotes  Diabetes mellitus 0 1 2 1 17 NA NA 0 1 0 0 22 (45)
T238 8319-8388 Sentence denotes  Chronic kidney diseasea 0 1 2 0 10 NA NA 0 0 0 0 13 (27)
T239 8389-8447 Sentence denotes  Lung disease 0 0 0 1 10 NA NA 1 1 0 0 13 (27)
T240 8448-8504 Sentence denotes  PCI for CAV 0 1 0 0 NA NA NA 0 1 0 1 3 (14)
T241 8505-8558 Sentence denotes  BMI >30 0 0 0 1 NA NA NA 0 NA 0 1 2 (12)
T242 8559-8582 Sentence denotes COVID-19 onset symptoms
T243 8583-8633 Sentence denotes  Fever 2 0 2 0 19 NA 1 1 4 3 6 38 (78)
T244 8634-8688 Sentence denotes  Chest pain 0 0 0 1 5 NA 0 0 0 1 NA 7 (16)
T245 8689-8762 Sentence denotes  Shortness of breath or cough 0 1 2 1 21 NA 1 1 4 2 6 39 (80)
T246 8763-8833 Sentence denotes  Gastrointestinal symptoms 1 0 2 0 11 NA 0 0 1 1 2 18 (37)
T247 8834-8852 Sentence denotes Treatment regimens
T248 8853-8883 Sentence denotes  Maintenance immunosuppression
T249 8884-8940 Sentence denotes   Cyclosporine 0 0 1 0 5 1 0 1 3 2 6 19 (35)
T250 8941-9008 Sentence denotes   Mycophenolate  mofetil 2 1 2 1 19 2 0 1 4 1 4 37 (69)
T251 9009-9064 Sentence denotes   Tacrolimus 2 0 1 1 22 3 1 0 1 1 0 32 (59)
T252 9065-9142 Sentence denotes   Proliferation sig-  nal inhibitors 0 1 0 0 5 1 0 0 0 0 1 8 (15)
T253 9143-9197 Sentence denotes   Azathioprine 0 0 0 0 0 0 0 0 0 2 0 2 (4)
T254 9198-9253 Sentence denotes   Prednisone 0 0 0 1 19 2 0 1 4 2 0 29 (54)
T255 9254-9293 Sentence denotes Number of immunosuppressive medications
T256 9294-9336 Sentence denotes  1 0 0 0 0 3 0 1 0 0 0 1 2 (8)
T257 9337-9381 Sentence denotes  2 2 1 2 0 8 3 0 0 0 1 5 14 (14)
T258 9382-9426 Sentence denotes  3 0 0 0 1 16 1 0 1 4 2 0 9 (35)
T259 9427-9469 Sentence denotes  4 0 0 0 0 1 0 0 0 0 0 0 0 (0)
T260 9470-9488 Sentence denotes COVID-19 treatment
T261 9489-9551 Sentence denotes  Hydroxychloroquine 0 1 2 1 18 3 0 1 4 1 5 36 (67)
T262 9552-9612 Sentence denotes  Lopinavir/ritonavir 0 0 1 0 0 0 0 0 2 0 2 5 (9)
T263 9613-9672 Sentence denotes  Remdesivir/placebo 0 0 0 1 0 0 0 0 0 0 0 1 (2)
T264 9673-9724 Sentence denotes  Umifenovir 1 0 0 0 0 0 0 0 0 0 0 1 (2)
T265 9725-9777 Sentence denotes  Oseltamivir 0 0 1 0 0 0 0 0 0 0 0 1 (2)
T266 9778-9828 Sentence denotes  Ribavirin 1 0 0 0 0 0 0 0 0 0 0 1 (2)
T267 9829-9875 Sentence denotes  IFN-b 0 0 0 0 0 0 0 0 1 0 0 1 (2)
T268 9876-9928 Sentence denotes  Ganciclovir 2 1 0 0 0 0 0 0 0 0 0 3 (6)
T269 9929-9982 Sentence denotes  Tocilizumab 0 0 2 0 6 0 0 0 0 0 0 8 (15)
T270 9983-10039 Sentence denotes  Steroid bolus 1 0 1 0 8 0 0 1 0 1 5 17 (31)
T271 10040-10085 Sentence denotes  IVIG 1 0 1 0 0 0 0 0 0 0 0 2 (4)
T272 10086-10112 Sentence denotes Immunosuppressant strategy
T273 10113-10171 Sentence denotes  Dose reduction 0 0 0 0 6 NA 0 0 0 1 5 12 (24)
T274 10172-10238 Sentence denotes  At least 1 withdrawal 1 1 2 1 16 NA 0 0 4 1 1 27 (55)
T275 10239-10301 Sentence denotes Acute graft rejection 0 0 0 0 0 NA 0 0 0 0 0 0 (0)
T276 10302-10316 Sentence denotes Major outcomes
T277 10317-10374 Sentence denotes  Hospitalized 2 1 2 1 22 NA 0 1 4 2 5 40 (82)
T278 10375-10436 Sentence denotes  Need for ICU stay 0 1 1 1 NA NA 0 0 2 0 2 7 (33)
T279 10437-10501 Sentence denotes  Invasive ventilation 0 0 1 0 NA NA 0 0 2 0 1 4 (19)
T280 10502-10570 Sentence denotes  Self quarantined at home 0 0 0 0 6 NA 1 0 0 2 1 10 (20)
T281 10571-10619 Sentence denotes  Death 0 0 0 0 7 1 0 0 1 0 2 11 (20)
T282 10620-10675 Sentence denotes  Discharged 2 1 1 1 11 NA 0 0 2 2 3 23 (47)
T283 10676-10740 Sentence denotes  Remained hospitalized 0 0 1 0 4 NA 0 1 1 0 0 7 (14)
T284 10741-11027 Sentence denotes BMI: body mass index; CAV: cardiac allograft vasculopathy; HTx: heart transplant; IFN-b: interferon-beta; ICU: intensive care unit; IVIG: intravenous gamma globulin; NA: not available; PCI: percutaneous coronary intervention; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.
T285 11028-11116 Sentence denotes a Defined by a glomerular filtration rate ˂30 ml/min and the presence of haemodialysis.
T286 11117-11194 Sentence denotes The mortality rate remains higher compared to that of the overall population.
T287 11195-11295 Sentence denotes It is still unclear whether any of the adopted approaches actually influence prognosis and survival.
T288 11296-11452 Sentence denotes Our adopted therapeutic strategy resulted in one-third mortality in this particular population at risk of severe illness from infection with the SARS-CoV-2.
T289 11453-11600 Sentence denotes One patient of advanced age with an already documented cardiac allograft vasculopathy did not overcome the disease, having developed a severe form.
T290 11601-11738 Sentence denotes Available data show a higher mortality rate among older male patients with cardiovascular comorbidities who are infected with SARS-CoV-2.
T291 11739-11910 Sentence denotes Furthermore, we must consider that during the outbreak the maximum standard of care was not achievable for all due to the limited availability of intensive care unit beds.
T292 11911-12062 Sentence denotes The other death was the consequence of a complicated course of hospitalization for a patient not responsive to antibiotic therapy who developed sepsis.
T293 12063-12215 Sentence denotes In addition, in 1 case we even managed to treat the infection at home in an unprecedented era in which healthcare resources are limited by the pandemic.
T294 12216-12383 Sentence denotes Apart from a bacterial superinfection and progression of respiratory disease, the only major complication that occurred during hospitalization was an ischaemic stroke.
T295 12384-12588 Sentence denotes Anecdotal cases regarding neurological events in patients with COVID-19 have been reported in the literature to date [28] and evidenced shows a hypercoagulability state in patients with severe forms [29].
T296 12589-12680 Sentence denotes Further investigations are needed to understand the aetiopathogenesis of this complication.
T297 12682-12693 Sentence denotes Limitations
T298 12694-12797 Sentence denotes The major limitations regarding our experience are related to the small size of the population studied.
T299 12798-12947 Sentence denotes Months after the beginning of the pandemic, mounting evidence is emerging for therapy and supportive care practices for managing COVID-19 infections.
T300 12948-13082 Sentence denotes More studies are needed to evaluate and correlate clinical and laboratory data to support our immunosuppressive modification strategy.
T301 13083-13250 Sentence denotes The cohort of heart transplant recipients makes up a minimal part of the affected population and the need to collect patients in a multicentre study remains essential.