PMC:7665480 / 13078-14362 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7665480","sourcedb":"PMC","sourceid":"7665480","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7665480","text":"Pharmacological treatment\nCollected data are provided in Table 1. During hospitalization hydroxychloroquine and broad-spectrum antibiotics for prophylaxis were administered to all patients. Ritonavir/lopinavir were used for 2 patients.\nOur adopted strategy for immunosuppressive therapy comprised a median reduction of 50% (IQR 40–80) of cyclosporine doses and 50% (IQR 13–69) of mycophenolate. In all hospitalized patients, a 0.5–1 mg/kg/day bolus of prednisone was administered for the first 7 days. Those intubated or in serious condition were given an equivalent intravenous dose of methylprednisolone. Progressive tapering then followed, leading to a low maintenance dose of 5–10 mg/day at discharged. Immunosuppressive therapy remained reduced until the first outpatient follow-up examination. At that time, the original immunosuppressive regime was resumed and corticosteroid therapy was discontinued. No graft rejection episodes occurred.\nThe patient who self-quarantined at home was treated with a broad-spectrum antibiotic and had a rapid remission of symptoms and resolution of fever. No immunosuppressive therapy modifications were made and no anti-inflammatory agents were administered. The results of the nasopharyngeal swab test for SARS-CoV-2 at 14 days were 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