PMC:7652766 / 84718-85592
Annnotations
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T125 | 862-873 | Phenotype | denotes | lymphopenia | http://purl.obolibrary.org/obo/HP_0001888 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T413 | 0-265 | Sentence | denotes | In a case study conducted by Monneret et al. (301), compassionate administration of IL-7 to a patient with severe COVID-19 significantly improved total lymphocyte count and HLA-DR expression in circulating monocytes four days after administration of the first dose. |
| T414 | 266-360 | Sentence | denotes | The patient also showed a significant improvement in lung involvement and negative viral load. |
| T415 | 361-733 | Sentence | denotes | Another study conducted by Laterre et al. (302), who administered IL-7 to COVID-19 patients found that there was a significant improvement in the lymphocyte count after starting treatment, in addition, the patients did not show any change in TNF-α levels, IL-1β, and IL-12p70, which may indicate that IL-7 therapy may be safe for patients with severe inflammatory changes. |
| T416 | 734-874 | Sentence | denotes | Thus, the use of IL-7-based immunotherapy can be an important tool to be used in future clinical trials in patients with severe lymphopenia. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 3085 | 84-88 | Gene | denotes | IL-7 | Gene:3574 |
| 3086 | 427-431 | Gene | denotes | IL-7 | Gene:3574 |
| 3087 | 603-608 | Gene | denotes | TNF-α | Gene:7124 |
| 3088 | 617-622 | Gene | denotes | IL-1β | Gene:3552 |
| 3089 | 662-666 | Gene | denotes | IL-7 | Gene:3574 |
| 3090 | 751-755 | Gene | denotes | IL-7 | Gene:3574 |
| 3091 | 432-434 | Gene | denotes | to | Gene:6999 |
| 3092 | 89-91 | Gene | denotes | to | Gene:6999 |
| 3093 | 94-101 | Species | denotes | patient | Tax:9606 |
| 3094 | 270-277 | Species | denotes | patient | Tax:9606 |
| 3095 | 444-452 | Species | denotes | patients | Tax:9606 |
| 3096 | 567-575 | Species | denotes | patients | Tax:9606 |
| 3097 | 691-699 | Species | denotes | patients | Tax:9606 |
| 3098 | 841-849 | Species | denotes | patients | Tax:9606 |
| 3099 | 474-475 | Gene | denotes | a | Gene:351 |
| 3100 | 290-291 | Gene | denotes | a | Gene:351 |
| 3101 | 92-93 | Gene | denotes | a | Gene:351 |
| 3102 | 3-4 | Gene | denotes | a | Gene:351 |
| 3103 | 114-122 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 3104 | 435-443 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 3105 | 862-873 | Disease | denotes | lymphopenia | MESH:D008231 |