PMC:7652766 / 64984-65841 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7652766","sourcedb":"PMC","sourceid":"7652766","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7652766","text":"In recovered patients, the magnitude of the production of neutralizing antibodies (nAb) against SARS-CoV-2 is positively correlated with the severity of the disease; while asymptomatic individuals have little or no capacity to produce nAb, individuals who recovered from severe cases of COVID-19 had robust nAb production. Also, these severe recovered patients showed an increase in B cell receptor (BCR) rearrangement, which may demonstrate that the effective production of nAb requires enhanced and prolonged BCR stimulation. Asymptomatic or mild symptomatic patients may possibly mount robust SARS-CoV-2 specific CD8 + T cell responses, which can provide protection by directly eliminating the target cells infected by the virus. However, due to the lack of immunity provided by nAb, these individuals might suffer from SARS-CoV-2 reinfection (200, 201).","tracks":[{"project":"LitCovid-sentences","denotations":[{"id":"T314","span":{"begin":0,"end":322},"obj":"Sentence"},{"id":"T315","span":{"begin":323,"end":527},"obj":"Sentence"},{"id":"T316","span":{"begin":528,"end":732},"obj":"Sentence"},{"id":"T317","span":{"begin":733,"end":857},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T314","pred":"source","obj":"LitCovid-sentences"},{"subj":"T315","pred":"source","obj":"LitCovid-sentences"},{"subj":"T316","pred":"source","obj":"LitCovid-sentences"},{"subj":"T317","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2469","span":{"begin":616,"end":619},"obj":"Gene"},{"id":"2470","span":{"begin":746,"end":748},"obj":"Gene"},{"id":"2471","span":{"begin":224,"end":226},"obj":"Gene"},{"id":"2472","span":{"begin":13,"end":21},"obj":"Species"},{"id":"2473","span":{"begin":96,"end":106},"obj":"Species"},{"id":"2474","span":{"begin":352,"end":360},"obj":"Species"},{"id":"2475","span":{"begin":561,"end":569},"obj":"Species"},{"id":"2476","span":{"begin":596,"end":606},"obj":"Species"},{"id":"2477","span":{"begin":823,"end":833},"obj":"Species"},{"id":"2478","span":{"begin":287,"end":295},"obj":"Disease"},{"id":"2479","span":{"begin":710,"end":718},"obj":"Disease"}],"attributes":[{"id":"A2469","pred":"tao:has_database_id","subj":"2469","obj":"Gene:925"},{"id":"A2470","pred":"tao:has_database_id","subj":"2470","obj":"Gene:6999"},{"id":"A2471","pred":"tao:has_database_id","subj":"2471","obj":"Gene:6999"},{"id":"A2472","pred":"tao:has_database_id","subj":"2472","obj":"Tax:9606"},{"id":"A2473","pred":"tao:has_database_id","subj":"2473","obj":"Tax:2697049"},{"id":"A2474","pred":"tao:has_database_id","subj":"2474","obj":"Tax:9606"},{"id":"A2475","pred":"tao:has_database_id","subj":"2475","obj":"Tax:9606"},{"id":"A2476","pred":"tao:has_database_id","subj":"2476","obj":"Tax:2697049"},{"id":"A2477","pred":"tao:has_database_id","subj":"2477","obj":"Tax:2697049"},{"id":"A2478","pred":"tao:has_database_id","subj":"2478","obj":"MESH:C000657245"},{"id":"A2479","pred":"tao:has_database_id","subj":"2479","obj":"MESH:D007239"},{"subj":"2469","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2470","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2471","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2472","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2473","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2474","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2475","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2476","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2477","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2478","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2479","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sentences","color":"#eca893","default":true},{"id":"LitCovid-PubTator","color":"#9398ec"}]}]}}