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PMC:7652766 / 58811-59553 JSONTXT

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LitCovid-sentences

Id Subject Object Predicate Lexical cue
T284 0-354 Sentence denotes SARS-CoV-2 studies involving CD8+ T cells have shown exhaustion of the effector capacity of these cells over time by the reduction of granzyme B, perforins, and lysosome-associated membrane protein 1, also known as LAMP-1 or CD107a, described as a marker of cytotoxic cells’ degranulation and an important parameter to assess the activity of these cells.
T285 355-518 Sentence denotes CD8+ T cells from COVID-19 patients have a very marked activation phenotype with an increase in CD69, CD38, CD137, and CD44, especially in critically ill patients.
T286 519-742 Sentence denotes However, despite presenting an increase in these activation molecules, these cells also have enhanced cell exhaustion proteins, such as PD1, Tim3, CTLA-4, and TIGIT, especially in more critically ill patients (9, 154, 170).

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2289 29-32 Gene denotes CD8 Gene:925
2290 134-144 Gene denotes granzyme B Gene:3002
2291 146-199 Gene denotes perforins, and lysosome-associated membrane protein 1 Gene:3916
2292 215-221 Gene denotes LAMP-1 Gene:3916
2293 225-231 Gene denotes CD107a Gene:3916
2294 355-358 Gene denotes CD8 Gene:925
2295 451-455 Gene denotes CD69 Gene:969
2296 457-461 Gene denotes CD38 Gene:952
2297 463-468 Gene denotes CD137 Gene:3604
2298 474-478 Gene denotes CD44 Gene:960
2299 660-664 Gene denotes Tim3 Gene:84868
2300 666-672 Gene denotes CTLA-4 Gene:1493
2301 678-683 Gene denotes TIGIT Gene:201633
2302 316-318 Gene denotes to Gene:6999
2303 0-10 Species denotes SARS-CoV-2 Tax:2697049
2304 382-390 Species denotes patients Tax:9606
2305 509-517 Species denotes patients Tax:9606
2306 719-727 Species denotes patients Tax:9606
2307 396-397 Gene denotes a Gene:351
2308 246-247 Gene denotes a Gene:351
2309 373-381 Disease denotes COVID-19 MESH:C000657245
2310 494-508 Disease denotes critically ill MESH:D016638
2311 704-718 Disease denotes critically ill MESH:D016638