PMC:7652766 / 43002-43746 JSONTXT

{"project":"LitCovid-PD-HP","denotations":[{"id":"T91","span":{"begin":0,"end":15},"obj":"Phenotype"},{"id":"T92","span":{"begin":174,"end":193},"obj":"Phenotype"},{"id":"T93","span":{"begin":304,"end":320},"obj":"Phenotype"},{"id":"T94","span":{"begin":366,"end":371},"obj":"Phenotype"},{"id":"T95","span":{"begin":499,"end":514},"obj":"Phenotype"},{"id":"T96","span":{"begin":661,"end":667},"obj":"Phenotype"}],"attributes":[{"id":"A91","pred":"hp_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A92","pred":"hp_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A93","pred":"hp_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/HP_0100598"},{"id":"A94","pred":"hp_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/HP_0031273"},{"id":"A95","pred":"hp_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A96","pred":"hp_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/HP_0100806"}],"text":"Cytokine storms may have great relevance in the pathogenesis of COVID-19. The induction of inflammatory mediators can induce cell damage, especially in lung tissues, causing respiratory failure. In addition, several of these mediators have potent vasodilator activity, which at the local level can cause pulmonary edemas, while at the systemic level leads to septic shock, worsening the clinical condition of these individuals. Similarly, several studies have shown that viral infections can induce cytokine storms, or take advantage of it, to establish infection and escape from the immune system, intensifying pathological phenomena such as those observed in sepsis, in addition to increasing the mortality rate of this population (160, 161)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T210","span":{"begin":0,"end":73},"obj":"Sentence"},{"id":"T211","span":{"begin":74,"end":194},"obj":"Sentence"},{"id":"T212","span":{"begin":195,"end":427},"obj":"Sentence"},{"id":"T213","span":{"begin":428,"end":744},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Cytokine storms may have great relevance in the pathogenesis of COVID-19. The induction of inflammatory mediators can induce cell damage, especially in lung tissues, causing respiratory failure. In addition, several of these mediators have potent vasodilator activity, which at the local level can cause pulmonary edemas, while at the systemic level leads to septic shock, worsening the clinical condition of these individuals. Similarly, several studies have shown that viral infections can induce cytokine storms, or take advantage of it, to establish infection and escape from the immune system, intensifying pathological phenomena such as those observed in sepsis, in addition to increasing the mortality rate of this population (160, 161)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1699","span":{"begin":681,"end":683},"obj":"Gene"},{"id":"1700","span":{"begin":541,"end":543},"obj":"Gene"},{"id":"1701","span":{"begin":356,"end":358},"obj":"Gene"},{"id":"1702","span":{"begin":64,"end":72},"obj":"Disease"},{"id":"1703","span":{"begin":174,"end":193},"obj":"Disease"},{"id":"1704","span":{"begin":304,"end":320},"obj":"Disease"},{"id":"1705","span":{"begin":359,"end":371},"obj":"Disease"},{"id":"1706","span":{"begin":471,"end":487},"obj":"Disease"},{"id":"1707","span":{"begin":554,"end":563},"obj":"Disease"},{"id":"1708","span":{"begin":661,"end":667},"obj":"Disease"},{"id":"1709","span":{"begin":699,"end":708},"obj":"Disease"}],"attributes":[{"id":"A1699","pred":"tao:has_database_id","subj":"1699","obj":"Gene:6999"},{"id":"A1700","pred":"tao:has_database_id","subj":"1700","obj":"Gene:6999"},{"id":"A1701","pred":"tao:has_database_id","subj":"1701","obj":"Gene:6999"},{"id":"A1702","pred":"tao:has_database_id","subj":"1702","obj":"MESH:C000657245"},{"id":"A1703","pred":"tao:has_database_id","subj":"1703","obj":"MESH:D012131"},{"id":"A1704","pred":"tao:has_database_id","subj":"1704","obj":"MESH:D011654"},{"id":"A1705","pred":"tao:has_database_id","subj":"1705","obj":"MESH:D012772"},{"id":"A1706","pred":"tao:has_database_id","subj":"1706","obj":"MESH:D001102"},{"id":"A1707","pred":"tao:has_database_id","subj":"1707","obj":"MESH:D007239"},{"id":"A1708","pred":"tao:has_database_id","subj":"1708","obj":"MESH:D018805"},{"id":"A1709","pred":"tao:has_database_id","subj":"1709","obj":"MESH:D003643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Cytokine storms may have great relevance in the pathogenesis of COVID-19. The induction of inflammatory mediators can induce cell damage, especially in lung tissues, causing respiratory failure. In addition, several of these mediators have potent vasodilator activity, which at the local level can cause pulmonary edemas, while at the systemic level leads to septic shock, worsening the clinical condition of these individuals. Similarly, several studies have shown that viral infections can induce cytokine storms, or take advantage of it, to establish infection and escape from the immune system, intensifying pathological phenomena such as those observed in sepsis, in addition to increasing the mortality rate of this population (160, 161)."}