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PMC:7652766 / 21979-22687 JSONTXT

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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T13 185-202 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T117 0-268 Sentence denotes Therefore, considering that SARS-CoV-2 uses ACE2 to enter cells, the main hypothesis of pulmonary pathology is that the increased activity of ACE (Ang-II) over ACE2 (Ang-1-7) may cause acute lung injury since the binding of the S protein to ACE2 leads to its blockage.
T118 269-496 Sentence denotes Thus, the suppression of ACE2 occurs due to the increased internalization and release of ACE2 from the cell surface, which leads to a decrease in tissue ACE2 and the generation of Ang-1-7, and consequently higher Ang-II levels.
T119 497-708 Sentence denotes Because of this, as shown in an experimental SARS-CoV-1 model, this process can drive an Ang II-AT1R-mediated inflammatory response in the lungs and potentially induce direct parenchymal injury (67, 80, 86, 87).

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
841 44-48 Gene denotes ACE2 Gene:59272
842 142-145 Gene denotes ACE Gene:1636
843 147-153 Gene denotes Ang-II Gene:183
844 160-164 Gene denotes ACE2 Gene:59272
845 166-173 Gene denotes Ang-1-7 Gene:284
846 241-245 Gene denotes ACE2 Gene:59272
847 294-298 Gene denotes ACE2 Gene:59272
848 358-362 Gene denotes ACE2 Gene:59272
849 422-426 Gene denotes ACE2 Gene:59272
850 449-456 Gene denotes Ang-1-7 Gene:284
851 482-488 Gene denotes Ang-II Gene:183
852 593-597 Gene denotes AT1R Gene:185
853 586-589 Gene denotes Ang Gene:283
854 398-400 Gene denotes to Gene:6999
855 310-312 Gene denotes to Gene:6999
856 252-254 Gene denotes to Gene:6999
857 238-240 Gene denotes to Gene:6999
858 49-51 Gene denotes to Gene:6999
859 28-38 Species denotes SARS-CoV-2 Tax:2697049
860 542-550 Species denotes SARS-CoV Tax:694009
861 401-402 Gene denotes a Gene:351
862 185-202 Disease denotes acute lung injury MESH:D055371
863 672-690 Disease denotes parenchymal injury MESH:D002543