PMC:7652766 / 14208-14889 JSONTXT

{"project":"LitCovid-sentences","denotations":[{"id":"T79","span":{"begin":0,"end":245},"obj":"Sentence"},{"id":"T80","span":{"begin":246,"end":408},"obj":"Sentence"},{"id":"T81","span":{"begin":409,"end":681},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The binding of the virus to the ACE2 receptor causes stabilization of the RBD in the standing-up state and triggers conformational changes in the S complex, resulting in the release of the S1 subunit and activation of S2 fusogenic activity (55). The S2 subunit contains an N-terminal fusion peptide (FP), heptad repeat 1 (HR1), heptad repeat 2 (HR2), a transmembrane region (TM), and a cytoplasmic tail (CT). During the fusion process, the FP portion is exposed and inserts into the membrane of the target cell, leading to a modification in S2, then the HR1 and HR2 come together to form a six-helical bundle (6-HR) structure, which allows the fusion between the membranes (55–57)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"566","span":{"begin":32,"end":36},"obj":"Gene"},{"id":"567","span":{"begin":580,"end":582},"obj":"Gene"},{"id":"568","span":{"begin":520,"end":522},"obj":"Gene"},{"id":"569","span":{"begin":25,"end":27},"obj":"Gene"},{"id":"570","span":{"begin":588,"end":589},"obj":"Gene"},{"id":"571","span":{"begin":523,"end":524},"obj":"Gene"},{"id":"572","span":{"begin":384,"end":385},"obj":"Gene"},{"id":"573","span":{"begin":351,"end":352},"obj":"Gene"}],"attributes":[{"id":"A566","pred":"tao:has_database_id","subj":"566","obj":"Gene:59272"},{"id":"A567","pred":"tao:has_database_id","subj":"567","obj":"Gene:6999"},{"id":"A568","pred":"tao:has_database_id","subj":"568","obj":"Gene:6999"},{"id":"A569","pred":"tao:has_database_id","subj":"569","obj":"Gene:6999"},{"id":"A570","pred":"tao:has_database_id","subj":"570","obj":"Gene:351"},{"id":"A571","pred":"tao:has_database_id","subj":"571","obj":"Gene:351"},{"id":"A572","pred":"tao:has_database_id","subj":"572","obj":"Gene:351"},{"id":"A573","pred":"tao:has_database_id","subj":"573","obj":"Gene:351"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The binding of the virus to the ACE2 receptor causes stabilization of the RBD in the standing-up state and triggers conformational changes in the S complex, resulting in the release of the S1 subunit and activation of S2 fusogenic activity (55). The S2 subunit contains an N-terminal fusion peptide (FP), heptad repeat 1 (HR1), heptad repeat 2 (HR2), a transmembrane region (TM), and a cytoplasmic tail (CT). During the fusion process, the FP portion is exposed and inserts into the membrane of the target cell, leading to a modification in S2, then the HR1 and HR2 come together to form a six-helical bundle (6-HR) structure, which allows the fusion between the membranes (55–57)."}